European Heart Journal - Cardiovascular Pharmacotherapy,
Год журнала:
2023,
Номер
10(2), С. 118 - 127
Опубликована: Ноя. 28, 2023
Omega-3
fatty
acids
and
fenofibrates
have
shown
some
beneficial
cardiovascular
effects;
however,
their
efficacy
has
not
been
compared.
This
study
aimed
to
compare
the
effectiveness
of
currently
available
omega-3
fenofibrate
for
reducing
major
adverse
events
(MACE).
From
a
nationwide
population-based
cohort
in
South
Korea
(2008-2019),
individuals
with
metabolic
syndrome
(≥30
years)
who
received
statin
those
receiving
were
matched
by
propensity
score
(n
=
39
165
both
groups).
The
primary
outcome
was
MACE,
including
ischaemic
heart
disease
(IHD),
stroke
(IS),
death
from
causes.
risk
MACE
lower
[hazard
ratio
(HR),
0.79;
95%
confidence
interval
(CI),
0.74-0.83]
group
than
acid
group.
Fenofibrate
associated
incidence
IHD
(HR,
0.72;
CI,
0.67-0.77)
hospitalization
failure
0.90;
0.82-0.97),
but
IS
0.81-1.00)
nor
causes
1.07;
0.97-1.17).
effect
compared
prominent
patients
preexisting
atherosclerotic
doses
(≤2
g
per
day).
In
real-world
setting,
use
low-dose
when
added
statins
people
syndrome.
Nutrients,
Год журнала:
2024,
Номер
16(4), С. 534 - 534
Опубликована: Фев. 14, 2024
We
aimed
to
investigate
the
association
of
a
sustainable
diet
with
long-term
reduction
in
waist
circumference
(WC)
while
identifying
novel
biomarkers
for
WC
(WCR).
The
participants
were
recruited
initially
during
2004-2013
large
hospital-based
cohort,
and
follow-up
measurements
conducted
2012-2016.
65,611
adults
aged
45-75
categorized
into
WC-loss
(
Metabolic
abnormalities
such
as
central
obesity,
insulin
resistance,
dyslipidaemia
and
hypertension,
often
referred
to
'the
metabolic
syndrome'
(or
'combined
abnormalities'),
are
increasingly
being
identified
in
people
living
with
type
1
diabetes,
accelerating
the
risk
for
CVD.
As
a
result,
recent
years,
treatment
diabetes
has
shifted
improving
overall
health
rather
than
glucose
control
alone.
In
Belgium,
care
is
centrally
organised.
The
Initiative
Quality
Improvement
Epidemiology
Diabetes,
imposed
by
Belgian
insurance
system,
systematically
collected
data
from
patients
on
intensive
therapy
treated
all
101
clinics
Belgium
since
2001.
aim
of
this
real-world
study
describe
evolution
health,
including
prevalence
obesity
combined
abnormalities,
over
past
20
compare
complications
between
those
without
abnormalities.
Molecular Medicine Reports,
Год журнала:
2025,
Номер
31(3)
Опубликована: Янв. 24, 2025
Asiasarum
root
and
rhizome
(Asarum)
is
commonly
used
as
a
diaphoretic.
Due
to
its
warm
pungent
characteristics
in
traditional
Chinese
Korean
medicine,
it
considered
having
the
potential
prevent
disease.
The
present
study
investigated
effects
of
Asarum
extract
on
symptoms
obesity
mice,
regulation
energy
metabolism
liver
skeletal
muscle
tissues.
In
addition,
identify
molecular
targets
signaling
pathways
involved
mechanism
action
obesity,
network
pharmacological
docking
analysis
was
performed.
vitro
studies
demonstrated
that
significantly
increased
expression
regulators
[sirtuin
1
(SIRT1),
peroxisome
proliferator‑activated
receptor
γ
coactivator
1‑α
(PGC1α),
nuclear
respiratory
factor
1,
AMP‑activated
protein
kinase
(AMPK)
glucose
transporter
type
4
(GLUT4)]
myogenic
regulatory
factors
(MyoD,
myogenin
myosin
heavy
chain)
C2C12
myotubes.
Furthermore,
vivo
could
reduce
increases
body
weight,
levels
blood
glucose,
insulin,
total
cholesterol,
triglycerides
low‑density
lipoprotein
cholesterol
sera
obese
mice.
also
improved
pathological
changes
pancreatic
tissues
ratio
brown
fat
mass
weight.
reversed
gastrocnemius
activated
SIRT1,
PGC1α
AMPK
These
findings
indicated
may
exert
anti‑obesity
effects,
such
weight
loss,
decreases
lipid
metabolite
levels,
inhibition
damage.
Using
analysis,
mechanisms
underlying
were
explored,
particularly
DNA and Cell Biology,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 12, 2025
Cuproptosis
is
a
new
mode
of
cell
death
that
closely
related
to
mitochondrial
stress.
The
purpose
this
study
investigate
the
amount
copper,
copper-associated
genes
DLAT
and
FDX1
oxidative
stress
(OS)
status
in
obesity.
Since
there
close
relationship
between
OS
cuproptosis,
evaluating
effect
various
strategies
reduce
OS,
including
quercetin
(QUER)
caloric
restriction
(CR),
another
goal
study.
In
study,
30
male
BALB-C
mice
aged
8
weeks
weighing
25
g,
groups
receiving
normal
diet
(ND),
ND
with
QUER
(15
mg/kg,
IP)
CR,
high-fat
(HFD)
QUER,
CR
or
combination
both
were
used.
activities
antioxidant
enzymes
superoxide
dismutase
(SOD),
glutathione
peroxidase
(GPX),
reductase
(GR),
copper
liver
kidney
tissues,
expression
measured
all
studied
groups.
tissue
as
well
HFD
group
increased
significantly
compared
group.
their
could
tissues.
also
activity
GR,
SOD
GPX
serum,
liver,
Based
on
results,
especially
simultaneous
use
both,
was
able
its
cuproptosis.
These
effects
may
cuproptosis-associated
death.
Therefore,
antioxidants
be
promising
solution
protect
human
body
against
cuproptosis
conditions
like
Lipids in Health and Disease,
Год журнала:
2024,
Номер
23(1)
Опубликована: Ноя. 4, 2024
Stress
urinary
incontinence
(SUI),
a
common
disorder
of
the
pelvic
floor,
often
results
in
anxiety,
poor
quality
life,
and
psychological
issues
among
its
sufferers.
The
relationship
between
lipid
accumulation
products
(LAP)
stress-related
urine
remains
unclear.
This
research
aimed
to
investigate
any
possible
correlation
risk
SUI
level
products.
For
this
cross-sectional
research,
people
with
who
were
20
years
age
or
older
recruited
using
information
from
National
Health
Nutrition
Examination
Survey
(NHANES)
2005
2018.
A
weighted
multivariate
logistic
regression
model
was
used
evaluate
findings.
As
potential
biomarker,
product
levels
sorted
individuals
ascending
order
subjected
trend
test
(P
for
trend).
Additionally,
nonlinear
analysis
conducted
smooth
curve-fitting
methods.
Lipid
products'
effectiveness
predicting
evaluated
receiver
operating
characteristic
(ROC)
curves.
Finally,
subgroup
performed
confirm
that
connection
consistent
across
all
demographic
groups.
thorough
survey
on
14,945
participants
indicated
23.61%
respondents
had
SUI.
noteworthy
association
observed
higher
values
greater
probability
analysis.
Specifically,
stratification
into
quartiles
demonstrated
substantial
positive
upper
lower
quartiles,
as
evidenced
by
an
elevated
odds
ratio
(OR
=
1.92;
95%CI
1.51–2.44;
P
<
0.0001).
supported
link
consistency
cohorts
under
investigation.
ROC
curve
(AUC
0.67,
0.654–0.690)
superior
predictive
effect
likelihood
Increased
are
associated
chance
adult
participants.
suggests
could
be
valuable
marker
detecting
SUI,
offering
new
perspectives
evaluation
treatment.
Nutrients,
Год журнала:
2022,
Номер
14(14), С. 2795 - 2795
Опубликована: Июль 7, 2022
Non-alcoholic
fatty
liver
disease
is
a
chronic
caused
by
the
accumulation
of
fat
in
related
to
overweight
and
obesity,
insulin
resistance,
hyperglycemia,
high
levels
triglycerides
leads
an
increased
cardiovascular
risk.
It
considered
global
pandemic,
coinciding
with
pandemic
2020
"coronavirus
2019"
(COVID-19).
Due
COVID-19,
population
was
placed
under
lockdown.
The
aim
our
study
evaluate
how
these
unhealthy
lifestyle
modifications
influenced
appearance
metabolic
alterations
increase
non-alcoholic
disease.
A
prospective
carried
out
on
6236
workers
Spanish
between
March
2019
2021.
Differences
mean
values
anthropometric
clinical
parameters
before
after
lockdown
were
revealed.
There
statistically
significant
worsening
(NAFLD)
resistance
scales,
body
weight,
BMI,
cholesterol
higher
LDL
levels,
glucose
reduction
HDL
levels.
Lockdown
risk
factors
due
estimation
scales
presenting
NAFLD
changes
resistance.