Design, synthesis and evaluation of 2-pyrimidinylindole derivatives as anti-obesity agents by regulating lipid metabolism

European Journal of Medicinal Chemistry, Год журнала: 2023, Номер 260, С. 115729 - 115729

Опубликована: Авг. 19, 2023

Язык: Английский

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Association of a High Healthy Eating Index Diet with Long-Term Visceral Fat Loss in a Large Longitudinal Study

Nutrients, Год журнала: 2024, Номер 16(4), С. 534 - 534

Опубликована: Фев. 14, 2024

We aimed to investigate the association of a sustainable diet with long-term reduction in waist circumference (WC) while identifying novel biomarkers for WC (WCR). The participants were recruited initially during 2004-2013 large hospital-based cohort, and follow-up measurements conducted 2012-2016. 65,611 adults aged 45-75 categorized into WC-loss (

Язык: Английский

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Metabolic health in people living with type 1 diabetes in Belgium: a repeated cross-sectional study

Diabetologia, Год журнала: 2024, Номер unknown

Опубликована: Сен. 13, 2024

Metabolic abnormalities such as central obesity, insulin resistance, dyslipidaemia and hypertension, often referred to 'the metabolic syndrome' (or 'combined abnormalities'), are increasingly being identified in people living with type 1 diabetes, accelerating the risk for CVD. As a result, recent years, treatment diabetes has shifted improving overall health rather than glucose control alone. In Belgium, care is centrally organised. The Initiative Quality Improvement Epidemiology Diabetes, imposed by Belgian insurance system, systematically collected data from patients on intensive therapy treated all 101 clinics Belgium since 2001. aim of this real-world study describe evolution health, including prevalence obesity combined abnormalities, over past 20 compare complications between those without abnormalities.

Язык: Английский

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Ameliorative effects of Asiasarum root and rhizome extract on high fat diet‑induced obesity in mice through regulation of the SIRT1/PGC1α/AMPK pathways in muscle and liver tissues

Molecular Medicine Reports, Год журнала: 2025, Номер 31(3)

Опубликована: Янв. 24, 2025

Asiasarum root and rhizome (Asarum) is commonly used as a diaphoretic. Due to its warm pungent characteristics in traditional Chinese Korean medicine, it considered having the potential prevent disease. The present study investigated effects of Asarum extract on symptoms obesity mice, regulation energy metabolism liver skeletal muscle tissues. In addition, identify molecular targets signaling pathways involved mechanism action obesity, network pharmacological docking analysis was performed. vitro studies demonstrated that significantly increased expression regulators [sirtuin 1 (SIRT1), peroxisome proliferator‑activated receptor γ coactivator 1‑α (PGC1α), nuclear respiratory factor 1, AMP‑activated protein kinase (AMPK) glucose transporter type 4 (GLUT4)] myogenic regulatory factors (MyoD, myogenin myosin heavy chain) C2C12 myotubes. Furthermore, vivo could reduce increases body weight, levels blood glucose, insulin, total cholesterol, triglycerides low‑density lipoprotein cholesterol sera obese mice. also improved pathological changes pancreatic tissues ratio brown fat mass weight. reversed gastrocnemius activated SIRT1, PGC1α AMPK These findings indicated may exert anti‑obesity effects, such weight loss, decreases lipid metabolite levels, inhibition damage. Using analysis, mechanisms underlying were explored, particularly

Язык: Английский

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Polystyrene microplastics impair brown and beige adipocyte function via the gut microbiota-adipose tissue crosstalk in high-fat diet mice

Journal of Hazardous Materials, Год журнала: 2025, Номер unknown, С. 138225 - 138225

Опубликована: Апрель 1, 2025

Язык: Английский

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Association of cardiometabolic index with gallstone disease and insulin resistance based on NHANES data

BMC Gastroenterology, Год журнала: 2025, Номер 25(1)

Опубликована: Май 9, 2025

Язык: Английский

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Modulation of Cuproptosis Pathway Genes (DLAT, FDX1) and Antioxidant Enzyme Activities in Obese Mice in Response to Quercetin and Calorie Restriction

DNA and Cell Biology, Год журнала: 2025, Номер unknown

Опубликована: Май 12, 2025

Cuproptosis is a new mode of cell death that closely related to mitochondrial stress. The purpose this study investigate the amount copper, copper-associated genes DLAT and FDX1 oxidative stress (OS) status in obesity. Since there close relationship between OS cuproptosis, evaluating effect various strategies reduce OS, including quercetin (QUER) caloric restriction (CR), another goal study. In study, 30 male BALB-C mice aged 8 weeks weighing 25 g, groups receiving normal diet (ND), ND with QUER (15 mg/kg, IP) CR, high-fat (HFD) QUER, CR or combination both were used. activities antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidase (GPX), reductase (GR), copper liver kidney tissues, expression measured all studied groups. tissue as well HFD group increased significantly compared group. their could tissues. also activity GR, SOD GPX serum, liver, Based on results, especially simultaneous use both, was able its cuproptosis. These effects may cuproptosis-associated death. Therefore, antioxidants be promising solution protect human body against cuproptosis conditions like

Язык: Английский

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Association between lipid accumulation products and stress urinary incontinence: a cross-sectional study from NHANES 2005 to 2018

Lipids in Health and Disease, Год журнала: 2024, Номер 23(1)

Опубликована: Ноя. 4, 2024

Stress urinary incontinence (SUI), a common disorder of the pelvic floor, often results in anxiety, poor quality life, and psychological issues among its sufferers. The relationship between lipid accumulation products (LAP) stress-related urine remains unclear. This research aimed to investigate any possible correlation risk SUI level products. For this cross-sectional research, people with who were 20 years age or older recruited using information from National Health Nutrition Examination Survey (NHANES) 2005 2018. A weighted multivariate logistic regression model was used evaluate findings. As potential biomarker, product levels sorted individuals ascending order subjected trend test (P for trend). Additionally, nonlinear analysis conducted smooth curve-fitting methods. Lipid products' effectiveness predicting evaluated receiver operating characteristic (ROC) curves. Finally, subgroup performed confirm that connection consistent across all demographic groups. thorough survey on 14,945 participants indicated 23.61% respondents had SUI. noteworthy association observed higher values greater probability analysis. Specifically, stratification into quartiles demonstrated substantial positive upper lower quartiles, as evidenced by an elevated odds ratio (OR = 1.92; 95%CI 1.51–2.44; P < 0.0001). supported link consistency cohorts under investigation. ROC curve (AUC 0.67, 0.654–0.690) superior predictive effect likelihood Increased are associated chance adult participants. suggests could be valuable marker detecting SUI, offering new perspectives evaluation treatment.

Язык: Английский

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Mechanistic insights into dietary (poly)phenols and vascular dysfunction-related diseases using multi-omics and integrative approaches: Machine learning as a next challenge in nutrition research

Molecular Aspects of Medicine, Год журнала: 2022, Номер 89, С. 101101 - 101101

Опубликована: Июнь 18, 2022

Язык: Английский

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Impact of COVID-19 Lockdown on Non-Alcoholic Fatty Liver Disease and Insulin Resistance in Adults: A before and after Pandemic Lockdown Longitudinal Study

Nutrients, Год журнала: 2022, Номер 14(14), С. 2795 - 2795

Опубликована: Июль 7, 2022

Non-alcoholic fatty liver disease is a chronic caused by the accumulation of fat in related to overweight and obesity, insulin resistance, hyperglycemia, high levels triglycerides leads an increased cardiovascular risk. It considered global pandemic, coinciding with pandemic 2020 "coronavirus 2019" (COVID-19). Due COVID-19, population was placed under lockdown. The aim our study evaluate how these unhealthy lifestyle modifications influenced appearance metabolic alterations increase non-alcoholic disease. A prospective carried out on 6236 workers Spanish between March 2019 2021. Differences mean values anthropometric clinical parameters before after lockdown were revealed. There statistically significant worsening (NAFLD) resistance scales, body weight, BMI, cholesterol higher LDL levels, glucose reduction HDL levels. Lockdown risk factors due estimation scales presenting NAFLD changes resistance.

Язык: Английский

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