Bioactive Apigenin‐7‐O‐β‐Glucoside and Rosmarinic Acid Molecules From Two Nepeta Species: Bioactivity‐Guided Isolation, In Vitro Evaluations, Pharmacokinetic and In Silico Approaches as Metabolic Enzyme Inhibition Agents DOI
Mesut Gök, Yunus Başar, Semiha Yenigün

и другие.

Phytochemical Analysis, Год журнала: 2025, Номер unknown

Опубликована: Апрель 27, 2025

ABSTRACT Introduction In this study, apigenin‐7‐ O ‐ β ‐glucoside (AGL) was isolated from Nepeta nuda ; also, rosmarinic acid (RA) N. aristata and . Objectives The aim of study is to investigate the enzyme inhibitory, DNA protective, antibacterial effects AGL RA two species. Material Methods 1D 2D NMR spectra an MS chromatogram were recorded identify RA. protection activities, inhibition, kinetics investigated Molecular interactions, molecular dynamics (MD) simulations, mechanics Poisson–Boltzmann surface area (MM‐PBSA) calculations, density functional theory (DFT), electrostatic potential (MEP) analyses, prediction activity for substances (PASS) predictions first time evaluate results. Results context, inhibitory properties higher in urease, α‐amylase, tyrosinase, whereas has a on lipase, CA, urease. addition, showed effective antimicrobial against Staphylococcus aureus , while it also deoxyribose protective activities. stability complex formed by urease with tyrosinase α‐amylase determined MD energy results evaluated MM‐PBSA analysis. DFT, MEP analysis, PASS that have soft structure can easily exchange electrons. Conclusion According obtained current explored as drug model.

Язык: Английский

Bioactive Properties and Chemical Compositions of Essential Oils From Three Nepeta L. Species, Two Endemic, Grown in Türkiye DOI
Bilge Aydın, Ayşe Cemre Kararenk, Hafize Yuca

и другие.

Flavour and Fragrance Journal, Год журнала: 2025, Номер unknown

Опубликована: Апрель 22, 2025

ABSTRACT Nepeta is one of the largest genera in Lamiaceae family. The aim this study to evaluate (DPPH • and ABTS + scavenging tests), antidiabetic ( α ‐amylase ‐glucosidase enzymes inhibition), anticholinesterase (acetylcholinesterase butyrylcholinesterase inhibition) activities methanolic, aqueous extracts essential oils obtained from flowering aerial parts N. cilicia Boiss. ex Benth., isaurica & Heldr. sulfuriflora P.H.Davis. Furthermore, extracted these plants were analysed for their chemical composition by GC–MS/MS. Also, anatomy morphology evaluated. Total phenolic tannin contents analysed. major compounds identified species as follows: caryophyllene oxide (24.8%) phytol (17.7%) , α‐cadinol (13.6%) ledol (8.0%) 1,8‐cineole (70.4%) sulfuriflora. are perennial, they have unicellular multicellular non‐glandular glandular trichomes. In assays, methanolic extract showed highest inhibition (31.66%), while oil had strongest (14.25%). For activity, was most effective against acetylcholinesterase (8.63%), MeOH (13.24%). It determined that especially higher % value on ·+ DPPH . When a comparison made terms total phenol content, it observed step ahead. conclusion, revealed three species— —possess significant bioactive properties, particularly antioxidant, antidiabetic, activities.

Язык: Английский

Процитировано

0
Bioactive Apigenin‐7‐O‐β‐Glucoside and Rosmarinic Acid Molecules From Two Nepeta Species: Bioactivity‐Guided Isolation, In Vitro Evaluations, Pharmacokinetic and In Silico Approaches as Metabolic Enzyme Inhibition Agents DOI
Mesut Gök, Yunus Başar, Semiha Yenigün

и другие.

Phytochemical Analysis, Год журнала: 2025, Номер unknown

Опубликована: Апрель 27, 2025

ABSTRACT Introduction In this study, apigenin‐7‐ O ‐ β ‐glucoside (AGL) was isolated from Nepeta nuda ; also, rosmarinic acid (RA) N. aristata and . Objectives The aim of study is to investigate the enzyme inhibitory, DNA protective, antibacterial effects AGL RA two species. Material Methods 1D 2D NMR spectra an MS chromatogram were recorded identify RA. protection activities, inhibition, kinetics investigated Molecular interactions, molecular dynamics (MD) simulations, mechanics Poisson–Boltzmann surface area (MM‐PBSA) calculations, density functional theory (DFT), electrostatic potential (MEP) analyses, prediction activity for substances (PASS) predictions first time evaluate results. Results context, inhibitory properties higher in urease, α‐amylase, tyrosinase, whereas has a on lipase, CA, urease. addition, showed effective antimicrobial against Staphylococcus aureus , while it also deoxyribose protective activities. stability complex formed by urease with tyrosinase α‐amylase determined MD energy results evaluated MM‐PBSA analysis. DFT, MEP analysis, PASS that have soft structure can easily exchange electrons. Conclusion According obtained current explored as drug model.

Язык: Английский

Процитировано

0