Biomaterials as Implants in the Orthopedic Field for Regenerative Medicine: Metal versus Synthetic Polymers

Polymers, Год журнала: 2023, Номер 15(12), С. 2601 - 2601

Опубликована: Июнь 7, 2023

Patients suffering bone fractures in different parts of the body require implants that will enable similar function to natural they are replacing. Joint diseases (rheumatoid arthritis and osteoarthritis) also surgical intervention with such as hip knee joint replacement. Biomaterial utilized fix or replace body. For majority these implant cases, either metal polymer biomaterials chosen order have a functional capacity original material. The employed most often for fracture metals stainless steel titanium, polymers polyethene polyetheretherketone (PEEK). This review compared metallic synthetic can be secure load-bearing due their ability withstand mechanical stresses strains body, focus on classification, properties, application.

Язык: Английский

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The Concept of Scaffold-Guided Bone Regeneration for the Treatment of Long Bone Defects: Current Clinical Application and Future Perspective

Journal of Functional Biomaterials, Год журнала: 2023, Номер 14(7), С. 341 - 341

Опубликована: Июнь 27, 2023

The treatment of bone defects remains a challenging clinical problem with high reintervention rates, morbidity, and resulting significant healthcare costs. Surgical techniques are constantly evolving, but outcomes can be influenced by several parameters, including the patient’s age, comorbidities, systemic disorders, anatomical location defect, surgeon’s preference experience. most used therapeutic modalities for regeneration long include distraction osteogenesis (bone transport), free vascularized fibular grafts, Masquelet technique, allograft, (arthroplasty with) mega-prostheses. Over past 25 years, three-dimensional (3D) printing, breakthrough layer-by-layer manufacturing technology that produces final parts directly from 3D model data, has taken off transformed enabling personalized therapies highly porous 3D-printed implants tailored to patient. Therefore, reduce morbidities complications associated current regimens, efforts have been made in translational research toward scaffolds facilitate regeneration. Three-dimensional printed should not only provide osteoconductive surfaces cell attachment subsequent formation also physical support containment graft material during process, enhancing ingrowth, while simultaneously, orthopaedic supply mechanical strength rigid, stable external and/or internal fixation. In this perspective review, we focus on elaborating history defect methods assessing approaches as well recent developments, existing evidence advantages disadvantages Furthermore, it is evident regulatory framework organization financing evidence-based trials very complex, new challenges non-biodegradable biodegradable emerging yet sufficiently addressed, such guideline development specific surgical indications, clinically feasible design concepts needed multicentre international preclinical trials, medico-legal status, reimbursement. These underscore need intensive exchange open honest debate among leaders field. This goal addressed well-planned focused stakeholder workshop topic patient-specific regeneration, proposed review.

Язык: Английский

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Bacterial Cellulose-Based Blends and Composites: Versatile Biomaterials for Tissue Engineering Applications

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(2), С. 986 - 986

Опубликована: Янв. 4, 2023

Cellulose of bacterial origin, known as cellulose (BC), is one the most versatile biomaterials that has a huge potential in tissue engineering due to its favourable mechanical properties, high hydrophilicity, crystallinity, and purity. Additional properties such porous nano-fibrillar 3D structure degree polymerisation BC mimic native extracellular matrix (ECM), making it an excellent material for fabrication composite scaffolds suitable cell growth development. Recently, BC-based scaffolds, including composites blends with nanomaterials, other biocompatible polymers received particular attention owing their desirable engineering. These have proven be promising advanced materials hard soft This review presents latest state-of-the-art modified/functionalised Their applicability ideal biomaterial targeted repair bone, cartilage, vascular, skin, nerve, cardiac been discussed. Additionally, this briefly summarises updates on production strategies characterisation blends. Finally, challenges future development direction research are also

Язык: Английский

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A review on chitosan and alginate-based microcapsules: Mechanism and applications in drug delivery systems

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 248, С. 125875 - 125875

Опубликована: Июль 19, 2023

Язык: Английский

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Polymeric Membranes for Biomedical Applications

Polymers, Год журнала: 2023, Номер 15(3), С. 619 - 619

Опубликована: Янв. 25, 2023

Polymeric membranes are selective materials used in a wide range of applications that require separation processes, from water filtration and purification to industrial separations. Because these materials’ remarkable properties, namely, selectivity, also biomedical Considering the fact most organs (apart heart brain) have processes associated with physiological function (kidneys, lungs, intestines, stomach, etc.), technological solutions been developed replace help polymer membranes. This review presents main membranes, such as hemodialysis (for chronic kidney disease), membrane-based artificial oxygenators lung), liver, pancreas, for osseointegration drug delivery systems based on

Язык: Английский

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Micro/Nano Encapsulated Phase Change Materials: Preparation, Principle, and Emerging Advances in Medical Field

Advanced Functional Materials, Год журнала: 2024, Номер 34(23)

Опубликована: Фев. 12, 2024

Abstract Due to the unique thermal absorption and release capabilities, phase‐change materials (PCMs) are used in various industrial fields, such as photo‐thermal storage building‐energy saving. In recent years, more research has been dedicated applying PCMs medical field with substantial progress, opening new avenues for disease treatment healthcare. The safety reliability of may be taken into serious consider continuous application field, while relevant review on related development is currently lacking. this work, methods enhancing applicability systematically summarized, including microencapsulation, electrospinning technology, porous framework encapsulation, which effectively address issues liquid leakage. Subsequently, emerging advances healthcare, dressings treatment, drug delivery, cold chain transport, bio‐bone cement summarized. By exploring analyzing encapsulation methods, principles well challenges perspectives promoting applications identified, presenting guidelines further development.

Язык: Английский

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Recent Advances in Two-Dimensional Nanomaterials for Healthcare Monitoring

ACS Sensors, Год журнала: 2024, Номер 9(4), С. 1706 - 1734

Опубликована: Апрель 2, 2024

The development of advanced technologies for the fabrication functional nanomaterials, nanostructures, and devices has facilitated biosensors analyses. Two-dimensional (2D) with unique hierarchical structures, a high surface area, ability to be functionalized target detection at surface, exhibit potential biosensing applications. electronic properties, mechanical flexibility, optical, electrochemical, physical properties 2D nanomaterials can easily modulated, enabling construction platforms various analytes targeted recognition, sensitivity, selectivity. This review provides an overview recent advances in nanostructures used biosensor wearable-sensor healthcare health-monitoring Finally, advantages 2D-nanomaterial-based several challenges their optimal operation have been discussed facilitate smart high-performance future.

Язык: Английский

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Estimating Biosafety of Biodegradable Biomedical Materials From In Vitro Ion Tolerance Parameters and Toxicity of Nanomaterials in Brain

Advances in healthcare information systems and administration book series, Год журнала: 2024, Номер unknown, С. 201 - 221

Опубликована: Фев. 9, 2024

Ensuring human health safety necessitates rigorous biosafety evaluations of substances and materials, particularly in the context in-vivo exposure. Biodegradable known for their natural decomposition capabilities through biological mechanisms, may exhibit toxicological profiles differing from non-biodegradable substances. Prior to application medical devices such as stents implants, it is imperative conduct thorough testing ascertain safety. This chapter aims provide a comprehensive assessment various biodegradable materials. The authors employ an integrative approach, combining in-vitro ion-tolerance assays with microanalysis techniques. dual methodology allows detailed evaluation materials' biocompatibility potential toxicity, focusing on nanomaterial-induced toxicity neural tissues. These findings offer critical insights into safe biomedical underpinning informed decision-making usage applications.

Язык: Английский

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Advances in sustainable grinding of different types of the titanium biomaterials for medical applications: A review

Biomedical Engineering Advances, Год журнала: 2022, Номер 4, С. 100047 - 100047

Опубликована: Июль 22, 2022

This review discusses various grades of titanium biomaterials and their sustainable grindability for application in the medical field. Titanium are most commonly utilized applications due to exceptional characteristics such as high corrosion resistance biocompatibility. The presented looks at principal requirements applications, some good mechanical properties, biocompatibility, corrosion, wear processability that facilitate successful implantation implants. It types alloys commercially available and, more specifically, used applications. highlights properties different further narrows down its primary focus on advantages, shortcomings biomaterials. Machining is a difficult task inherent low thermal conductivity chemical reactivity temperatures usually results changes metallurgy surface integrity machined surface. Conventional machining, which has been main machining method, limitations related environmental hazards, cutting fluid costs, operator health issues have necessitated development machining. emphasis this placed grinding techniques MQL cryogenic nano-particle high-pressure solid lubrication grind benefits limitations. Finally, will highlight potential areas future research trends cooling methods believed be great benefit industries involved manufacturing titanium-based

Язык: Английский

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Biocompatibility Testing for Implants: A Novel Tool for Selection and Characterization

Materials, Год журнала: 2023, Номер 16(21), С. 6881 - 6881

Опубликована: Окт. 26, 2023

This review article dives into the complex world of biocompatibility testing: chemical, mechanical, and biological characterization, including many elements biocompatibility, such as definitions, descriptive examples, practical settings. The focus extends to evaluating standard documents obtained from reliable organizations; with a particular on open-source information, FDA-USA, ISO 10933 series, TÜV SÜD. We found significant gap in this field: biomaterial scientists those involved realm medical device development general, implants particular, lack access tool that reorganizes process selecting appropriate test for implant being examined. work progressed through two key phases aimed provide solution gap. A straightforward “yes or no” flowchart was initially developed guide testing decisions based previously accumulated information. Subsequently, Python code employed, generating framework targeted questions. reshapes evaluation, bridging theory implementation. An integrated approach via empowers stakeholders navigate effortlessly. To conclude, researchers are now better equipped safer, more effective development, propelling field towards improved patient care innovative progress.

Язык: Английский

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