Trace
metals
are
essential
elements
that
play
key
roles
in
a
number
of
biochemical
processes
governing
human
visual
physiology
health
and
disease.
Several
trace
metals,
such
as
zinc,
have
been
shown
to
important
the
phototransduction
process.
In
spite
this,
there
has
little
research
conducted
on
direct
effect
metal
pho-toreceptor
rhodopsin.
current
study,
we
determined
several
ions,
iron,
copper,
chromium,
manganese,
nickel
conformational
stability
rho-dopsin.
To
this
aim,
analyzed,
by
means
UV-visible
fluorescence
spectroscopic
methods,
effects
these
thermal
dark
rhodopsin,
its
active
Metarhodopsin
II
conformation,
chromophore
regeneration.
Our
results
show
copper
prevented
rhodopsin
regeneration
slowed
down
retinal
release
process
after
il-lumination.
turn,
Fe3+,
but
not
Fe2+,
increased
inactive
con-formation
whereas
ions
markedly
decreased
it.
These
findings
stress
role
at
photoreceptor
level,
may
be
useful
for
development
novel
therapeutic
strategies
treat
Pharmacological Research,
Год журнала:
2024,
Номер
206, С. 107264 - 107264
Опубликована: Июнь 12, 2024
Disturbances
in
copper
(Cu)
homeostasis
have
been
observed
diabetes
and
associated
complications.
Cu
is
an
essential
micronutrient
that
plays
important
roles
various
fundamental
biological
processes.
For
example,
diabetic
cardiomyopathy
with
elevated
levels
of
the
serum
tissues.
Therefore,
targeting
may
be
a
novel
treatment
strategy
for
This
review
provides
overview
physiological
metabolism
homeostasis,
followed
by
discussion
disorders
during
occurrence
progression
Finally,
we
discuss
recent
therapeutic
advances
use
coordination
complexes
as
treatments
complications
their
potential
mechanisms
action.
contributes
to
complete
understanding
role
demonstrates
broad
application
prospects
Cu-coordinated
compounds
agents.
Biochemical Pharmacology,
Год журнала:
2022,
Номер
203, С. 115168 - 115168
Опубликована: Июль 12, 2022
Pathological
deterioration
of
mitochondrial
function
is
increasingly
linked
with
multiple
degenerative
illnesses
as
a
mediator
wide
range
neurologic
and
age-related
chronic
diseases,
including
those
genetic
origin.
Several
these
diseases
are
rare,
typically
defined
in
the
United
States
an
illness
affecting
fewer
than
200,000
people
U.S.
population,
or
about
one
1600
individuals.
Vision
impairment
due
to
dysfunction
eye
prominent
feature
evident
numerous
primary
common
pathophysiology
many
familiar
ophthalmic
disorders,
macular
degeneration,
diabetic
retinopathy,
glaucoma
retinopathy
prematurity
—
collection
syndromes,
disorders
significant
unmet
medical
needs.
Focusing
on
metabolic
pathway
mechanisms,
possible
roles
cuproptosis
ferroptosis
retinal
dysfunction,
we
shed
light
potential
α-lipoyl-L-carnitine
treating
diseases.
α-Lipoyl-L-carnitine
bioavailable
mitochondria-targeting
lipoic
acid
prodrug
that
has
shown
protecting
against
degeneration
photoreceptor
cell
loss
indications.
Abstract
Insulin
is
commonly
used
to
treat
diabetes
and
undergoes
aggregation
at
the
site
of
repeated
injections
in
diabetic
patients.
Moreover,
also
observed
during
its
industrial
production
transport
should
be
avoided
preserve
bioavailability
correctly
adjust
glucose
levels
However,
monitoring
effect
various
parameters
(pH,
protein
concentration,
metal
ions,
etc.)
on
insulin
oligomerization
state
very
challenging.
In
this
work,
we
have
applied
a
novel
Surface
Plasmon
Resonance
(SPR)‐based
experimental
approach
solutions
conditions,
how
diffusion
coefficient
affected
by
pH
presence
ions
(copper
zinc)
with
unprecedented
sensitivity,
precision,
reproducibility.
The
reported
SPR
method,
hereby
for
first
time,
besides
giving
insight
into
phenomena,
proved
robust
determining
any
biomolecule.
A
theoretical
background
given
together
software
description,
specially
designed
fit
data.
This
new
way
applying
represents
an
innovation
bio‐sensing
field
expanding
potentiality
instruments
well
over
canonical
investigation
biomolecular
interactions.
Antioxidants,
Год журнала:
2022,
Номер
11(11), С. 2250 - 2250
Опубликована: Ноя. 15, 2022
Diabetic
Retinopathy
(DR)
is
one
of
the
most
important
microvascular
complications
diabetes
mellitus,
which
can
lead
to
blindness
in
severe
cases.
Mitochondria
are
energy-producing
organelles
eukaryotic
cells,
participate
metabolism
and
signal
transduction,
regulate
cell
growth,
differentiation,
aging,
death.
Metabolic
changes
retinal
cells
epigenetic
mitochondria-related
genes
under
high
glucose
mitochondrial
dysfunction
induce
pathway
apoptosis.
In
addition,
mitophagy
dynamics
also
change
adaptively.
These
mechanisms
may
be
related
occurrence
progression
DR,
provide
valuable
clues
for
prevention
treatment
DR.
This
article
reviews
mechanism
DR
induced
by
dysfunction,
prospects
treatment.
Gene,
Год журнала:
2024,
Номер
930, С. 148861 - 148861
Опубликована: Авг. 15, 2024
By
identifying
molecular
biological
markers
linked
to
cuproptosis
in
diabetic
retinopathy
(DR),
new
pathobiological
pathways
and
more
accessible
diagnostic
can
be
developed.
BioMed Research International,
Год журнала:
2025,
Номер
2025(1)
Опубликована: Янв. 1, 2025
Globally,
diabetic
retinopathy
(DR)
and
macular
edema
(DME)
are
the
leading
causes
of
visual
loss
in
working
people.
Current
treatment
approaches
mostly
target
proliferative
DR
DME,
such
as
intravitreal
injections
antivascular
endothelial
growth
factor
agents
laser
photocoagulation.
Before
progresses
into
more
severe,
sight-threatening
stage,
patients
with
early
stages
disease
must
get
appropriate
care.
It
has
been
suggested
that
nutraceuticals,
which
natural
functional
foods
minimal
adverse
effects,
may
help
DME.
Several
vitro
vivo
studies
were
carried
out
over
last
years,
showing
potential
benefits
several
nutraceuticals
due
to
their
neuroprotective,
vasoprotective,
anti-inflammatory,
antioxidant
properties.
Although
most
research
is
restricted
animal
models
many
have
low
bioavailability,
these
compounds
adjuvate
implement
conventional
therapies.
The
purpose
this
review
(i)
summarize
complex
pathophysiology
underlying
DME
(ii)
examine
main
natural-derived
molecules
dietary
habits
can
assist
therapies
for
clinical
management
IntechOpen eBooks,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 25, 2025
Skeletal
muscle
senescence
is
a
significant
biological
process
in
the
aging
of
body,
marked
by
reduction
mass
and
function.
In
recent
years,
there
has
been
growing
interest
understanding
role
copper
skeletal
aging.
During
various
pathological
conditions,
often
exhibits
an
accumulation
excess
copper.
This
abnormal
buildup
can
trigger
specific
molecular
mechanisms
that
lead
to
programmed
cell
death
pathways
such
as
apoptosis,
pyroptosis,
ferroptosis,
cuproptosis,
well
promote
aggregation
α-synuclein.
These
effects
set
off
series
signal
cascades
ultimately
result
metabolic
imbalances
within
fibers,
including
protein,
mitochondrial,
satellite
dysfunction,
leading
degeneration
abnormalities
neuromuscular
junctions.
forms
new
pathophysiological
mechanism
for
atrophy.
Here,
we
provide
comprehensive
analysis
functions
regulatory
network
atrophy,
exploring
potential
overload
muscles
novel
roles
signaling
induced
overload.
Our
goal
offer
targets
therapeutic
options
improving
treating
atrophy
through
chelation
strategies
clinical
settings.
