Biochemical Genetics, Год журнала: 2023, Номер 62(2), С. 761 - 774
Опубликована: Июль 10, 2023
Язык: Английский
Biomolecules, Год журнала: 2021, Номер 11(8), С. 1090 - 1090
Опубликована: Июль 23, 2021
Particulate matter from forest fires (PMFF) is an environmental pollutant causing oxidative stress, inflammation, and cancer cell metastasis due to the presence of polycyclic aromatic hydrocarbons (PAHs). Perilla seed meal contains high levels polyphenols, including rosmarinic acid (RA). The aim this study determine anti-oxidative anti-inflammation, anti-metastasis actions rich fraction (RA-RF) perilla its underlying molecular mechanisms in A549 cells exposed PMFF. PMFF samples were collected via air sampler at University Phayao, Thailand, their PAH content analyzed using GC-MS. Fifteen compounds detected significantly induced intracellular reactive oxygen species (ROS) production, mRNA expression pro-inflammatory cytokines, MMP-9 activity, invasion, migration, overexpression c-Jun p-65-NF-κB, Akt phosphorylation. Additionally, RA-RF reduced ROS IL-6, IL-8, TNF-α, COX-2. could also suppress phosphorylation activity c-Jun, Akt. Our findings revealed that has antioxidant, anti-inflammatory, properties signaling pathways. may be further developed as inhalation agent for prevention lung inflammation by PM exposure.
Язык: Английский
Процитировано
32
Journal of Ethnopharmacology, Год журнала: 2022, Номер 292, С. 115197 - 115197
Опубликована: Март 21, 2022
Язык: Английский
Процитировано
23
Phytomedicine, Год журнала: 2024, Номер 135, С. 156060 - 156060
Опубликована: Сен. 19, 2024
Язык: Английский
Процитировано
5
Pharmaceutics, Год журнала: 2022, Номер 14(11), С. 2401 - 2401
Опубликована: Ноя. 7, 2022
Rosmarinic acid (RA) is a polyphenolic metabolite found in various culinary, dietary sources, and medicinal plants like Coleus scutellarioides (Linn) Benth., Lavandula angustifolia Linn., Mellisa officinalis Origanum vulgare Rosmarinus Zataria multiflora Boiss. Zhumeria majdae Rech. F. Apart from its therapeutic values, RA an important anticancer phytochemical owing to multi-targeting mechanism. These properties provide scope for RA’s uses beyond traditional use as source. However, oral bioavailability limited due poor solubility permeability. This impedes efficacy treating cancer. Indeed, recent years, tremendous efforts have been put towards the development of nanoformulations this research initial stage bringing nanoparticle into market itself associated with many issues such stability, toxicity, scale-up issues. Considering these pitfalls during formulation overcoming them would surely new face nanomedicine treat A literature search was conducted systematically review biological extraction techniques, mechanisms through which showed multiple effects. Various nanocarriers pertaining activity are also discussed review.
Язык: Английский
Процитировано
18
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(2), С. 1691 - 1691
Опубликована: Янв. 14, 2023
Natural products used for their health-promoting properties have accompanied the evolution of humanity. Nowadays, as an effort to scientifically validate effects described by traditional medicine, ever-growing number bioactivities are being natural and phytochemicals that constitute them. Among them, medicinal plants more specifically Thymus genus spp., arise already present in diet with high acceptance, a source pharmacological value. Phenolic acids, flavonoid glycoside derivatives, terpenoids from spp. been ability modulate cell death survival pathways, much-valued pharmaceutical industry, continually sought-after new formulations prevent undesired or control proliferation. these, wound treatment, protection endogenous/exogenous toxic molecules, induction selective death, such search anti-tumoral agents, main objectives. This review summarizes discusses studies on well compounds extracts, regard involving modulation signaling pathways. In addition, regarding bioactive molecules cellular molecular targets were also reviewed. Concerning proliferation, themselves option designed healing against chemicals-induced toxicity. However, extracts some regulate presenting activity. Therefore is rich nutraceutical
Язык: Английский
Процитировано
9
Journal for Research in Applied Sciences and Biotechnology, Год журнала: 2025, Номер 4(2), С. 64 - 76
Опубликована: Апрель 24, 2025
Holy basil, or Tulsi, is a plant native to the Indian subcontinent that highly valued in Siddha and Ayurvedic medicine for its therapeutic properties. Tulsi has been shown shield organs tissues from physical stressors such as extended activity, ischemia, restraint, exposure cold, loud noises, well chemical including industrial pollution heavy metals. Additionally, demonstrated mitigate psychological stress by improving memory cognitive performance lowering blood pressure, cholesterol, glucose levels. It also metabolic having anxiolytic antidepressant qualities. The predominant cause of global morbidity mortality lifestyle-related chronic diseases, many which can be addressed through Ayurveda with focus on healthy lifestyle practices regular consumption adaptogenic herbs. Scientific studies are increasingly verifying health benefits (Ocimum sanctum Linn), most important Ayurveda. special mix pharmacological activities have alleviate physical, physiological, metabolic, stress. broad-spectrum antimicrobial activity includes against variety human animal pathogens, indicates it used mouthwash, hand sanitiser, water purifier addition being wound healing, rearing, food preservation, preservation herbal raw materials, traveller’s issues.
Язык: Английский
Процитировано
0
Archives of Medical Research, Год журнала: 2024, Номер 55(4), С. 103005 - 103005
Опубликована: Май 17, 2024
Язык: Английский
Процитировано
3
Plants, Год журнала: 2023, Номер 12(16), С. 3006 - 3006
Опубликована: Авг. 21, 2023
Perilla frutescens (L.) Britt. is extensively cultivated in East Asia as a dietary vegetable, and nutraceuticals are reportedly rich bioactive compounds, especially with anticancer activities. This study explored the vitro cytotoxic effects of P. parts’ (stems, leaves, seeds) extracts on prostate cancer cells (DU-145) possible interactions putative metabolites to related targets silico. The ethanol extract leaves was most for cells. From high-performance liquid chromatography analysis, rosmarinic acid identified major metabolite leaf extracts. Network analysis revealed from multiple affected pathways metabolites. gene ontology enrichment could significantly affect 14 molecular functions 12 biological processes five cellular components. Four (4) KEGG pathways, including cancer, six (6) Reactome were shown be affected. simulation confirmed relevant protein key metabolites, acid. potentially lead further exploration or their treatment prevention.
Язык: Английский
Процитировано
7
Translational Oncology, Год журнала: 2022, Номер 26, С. 101549 - 101549
Опубликована: Сен. 30, 2022
Cancer stem cells (CSCs) in triple-negative breast cancer (TNBC) are closely related to tumorigenesis and metastasis. Thioridazine (THZ) is a usual phenothiazine antipsychotic drug that can destroy CSCs. We aimed explore whether THZ could sensitize metastatic TNBC cells, especially the CSCs, carboplatin (CBP) treatment. Metastatic 4T1 tumor-bearing mice were treated with CBP as monotherapy or combination therapy. MTT, flow cytometry, electron microscopy, immunohistochemistry western blotting applied assess cell viability, apoptosis, mitochondrial morphology relevant protein levels, respectively. Tumor size lung metastasis under different treatments well of residual tumor from each group monitored. combined inhibited proliferation induced apoptosis by inhibiting PI3K-AKT-mTOR pathway activating estrogen receptor stress. also showed strong activity against significantly destroyed relieved burden; Our data demonstrated treatment this therapy may provide bright strategy for targeting both
Язык: Английский
Процитировано
11
Life, Год журнала: 2024, Номер 14(8), С. 1017 - 1017
Опубликована: Авг. 15, 2024
Rosmarinic acid (RA) has demonstrated anticancer effects on several types of malignancies. However, whether RA promotes the effect cisplatin colorectal cancer cells remains sketchy. This study aimed to explore potentiates cytotoxicity against colon and underlying mechanism. Cell viability, cell cycle progression, apoptosis was evaluated using sulforhodamine B (SRB) assay, flow cytometric analysis, propidium iodide/Annexin V staining, respectively. Western blotting utilized analyze signaling pathways. Our findings showed that significantly enhanced inhibitory viability induction lines DLD-1 LoVo. Signaling cascade analysis revealed combination jointly induced Bax caspase activation while downregulating Bcl-2, glutathione peroxidase 4 (GPX4), SLC7A11 in cells. Moreover, inhibitor ferroptosis reversed inhibition response combined with cisplatin. Collectively, these demonstrate enhances cells, attributing promotion ferroptosis.
Язык: Английский
Процитировано
1