Bioactivity and Neuroprotective Effects of Extra Virgin Olive Oil in a Mouse Model of Cerebral Ischemia: An In Vitro and In Vivo Study DOI Open Access
Salvatore Scacco,

Silvia Acquaviva,

Fábio França Vieira e Silva

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(4), С. 1771 - 1771

Опубликована: Фев. 19, 2025

Cerebral ischemia is a pathological condition characterized by complete blood and oxygen supply deprivation to neuronal tissue. The ischemic brain compensates for the rapid decline in ATP levels increasing anaerobic glycolysis rate, which leads lactate accumulation subsequent acidosis. Astrocytes play critical role regulating cerebral energy metabolism. Mitochondria are significant targets hypoxia-ischemia injury, disruptions mitochondrial homeostasis cellular energetics worsen outcomes, especially elderly. Elevated of n-3 polyunsaturated fatty acids (PUFAs) protect adult neonatal from damage suppressing inflammation, countering oxidative stress, supporting neurovascular unit reconstruction, promoting oligodendrogenesis. This study examines extra virgin olive oil (EVOO) treatment on TNC WT M23 cells, focusing consumption reactive species (ROS) production. investigates effects different durations middle artery occlusion (MCAo) EVOO administration infarct volume, neurological scores, function, cell viability. volume increased with longer times, while (0.5 mg/kg/day) significantly reduced infarction across all MCAo durations. assays demonstrate EVOO's dose-dependent stimulation respiration astrocytes, particularly at lower concentrations. Furthermore, EVOO-treated cells reduce ROS production during hypoxia, improve viability under enhance conditions, underscoring neuroprotective potential.

Язык: Английский

Bioactivity and Neuroprotective Effects of Extra Virgin Olive Oil in a Mouse Model of Cerebral Ischemia: An In Vitro and In Vivo Study DOI Open Access
Salvatore Scacco,

Silvia Acquaviva,

Fábio França Vieira e Silva

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(4), С. 1771 - 1771

Опубликована: Фев. 19, 2025

Cerebral ischemia is a pathological condition characterized by complete blood and oxygen supply deprivation to neuronal tissue. The ischemic brain compensates for the rapid decline in ATP levels increasing anaerobic glycolysis rate, which leads lactate accumulation subsequent acidosis. Astrocytes play critical role regulating cerebral energy metabolism. Mitochondria are significant targets hypoxia-ischemia injury, disruptions mitochondrial homeostasis cellular energetics worsen outcomes, especially elderly. Elevated of n-3 polyunsaturated fatty acids (PUFAs) protect adult neonatal from damage suppressing inflammation, countering oxidative stress, supporting neurovascular unit reconstruction, promoting oligodendrogenesis. This study examines extra virgin olive oil (EVOO) treatment on TNC WT M23 cells, focusing consumption reactive species (ROS) production. investigates effects different durations middle artery occlusion (MCAo) EVOO administration infarct volume, neurological scores, function, cell viability. volume increased with longer times, while (0.5 mg/kg/day) significantly reduced infarction across all MCAo durations. assays demonstrate EVOO's dose-dependent stimulation respiration astrocytes, particularly at lower concentrations. Furthermore, EVOO-treated cells reduce ROS production during hypoxia, improve viability under enhance conditions, underscoring neuroprotective potential.

Язык: Английский

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