Prognosis and Treatment of Gastric Cancer: A 2024 Update
Cancers,
Год журнала:
2024,
Номер
16(9), С. 1708 - 1708
Опубликована: Апрель 27, 2024
Due
to
the
high
death
rate
associated
with
gastric
cancer,
a
great
deal
of
research
has
been
conducted
on
this
disease.
The
goal
paper
was
start
trimestral
review
2024
for
year
that
had
just
started.
scientific
literature
from
1
January
chosen
consideration
guidelines
European
Society
Medical
Oncology
(ESMO),
which
are
updated
new
findings
but
not
systematically
reviewed
annually.
We
used
search
term
“gastric
cancer”
find
most
current
publications
in
PubMed
database
related
prognosis
and
treatment
cancer.
As
previously
said,
only
articles
satisfied
inclusion
criteria
were
those
2024.
Articles
case
reports
eliminated
since
they
nothing
do
our
research.
cancer
is
focus
majority
primary
axes
include
surgery
immunonutrition,
immunotherapy
Helicobacter
pylori,
therapeutic
targets.
Patients
GC
may
experience
less
psychological,
social,
financial
hardship
if
recently
identified
markers
discovered
circulation
better
assessed
validated.
This
could
be
achieved
by
either
including
an
artificial
intelligence-based
diagnostic
score
or
using
them
conjunction
traditional
methods.
rising
GC,
funding
into
diagnosis,
prognosis,
therapy,
targets
essential.
Язык: Английский
Microfluidic systems for modeling digestive cancer: a review of recent progress
Biomedical Physics & Engineering Express,
Год журнала:
2024,
Номер
10(5), С. 052002 - 052002
Опубликована: Авг. 14, 2024
Abstract
Purpose
.
This
review
aims
to
highlight
current
improvements
in
microfluidic
devices
designed
for
digestive
cancer
simulation.
The
emphasizes
the
use
of
multicellular
3D
tissue
engineering
models
understand
complicated
biology
tumor
microenvironment
(TME)
and
progression.
purpose
is
develop
oncology
research
improve
patients’
lives.
Methods
analyzes
recent
on
mimicking
cancer.
It
uses
tissue-engineered
devices,
notably
organs
a
chip
(OOC),
simulate
human
organ
function
lab.
Cell
cultivation
modern
three-dimensional
hydrogel
platforms
allows
precise
geometry,
biological
components,
physiological
qualities.
novel
methodologies,
key
findings,
technical
progress
explain
this
field’s
advances.
Results
study
discusses
advances
Micro
systems
with
are
emphasized.
These
capture
complex
biochemical
gradients,
niche
variables,
dynamic
cell–cell
interactions
(TME).
reveal
stomach
progression
by
duplicating
TME.
Recent
discoveries
technology
have
improved
our
understanding
gut
biology,
as
shown
review.
Conclusion
Microfluidic
play
crucial
role
modeling
furthering
research.
could
transform
drug
development
treatment
revealing
provides
complete
summary
suggests
future
field
professionals.
review’s
major
goal
further
medical
Язык: Английский
Contemporary management of advanced gastric and gastroesophageal adenocarcinomas
Expert Review of Anticancer Therapy,
Год журнала:
2025,
Номер
unknown, С. 1 - 7
Опубликована: Фев. 7, 2025
Gastric
and
gastroesophageal
adenocarcinomas
(GEACs)
continue
to
carry
a
poor
prognosis
in
most
patients.
New
exciting
therapies
have
entered
the
treatment
landscape
recent
years.
Prior
these
approvals,
advances
had
been
limited.
Important
decision
biomarkers
for
metastatic
GEAC
are
microsatellite
instability-high/deficient
mismatch
repair,
human
epidermal
growth
factor
receptor-2,
programmed-death
ligand
1,
claudin
18.2
expression
among
others
(such
as
Epstein
Barr
Virus
(EBV)
agnostic
biomarkers).
Results
of
drive
therapy
decisions.
Second-line
cases
is
less
biomarker
driven
needs
further
progress.
Studies
molecular
subsets
has
led
understanding
that
heterogenous
diseases
need
be
treated
differently.
Other
with
targeted
being
studied
including
fibroblast
receptor,
trophoblast
cell
surface
antigen-2,
receptor.
Additionally,
epidemiological
distinctions
starting
such
EBV
GAC.
Язык: Английский
Evolving Landscape of HER2-Targeted Therapies for Gastric Cancer Patients
Lijuan He,
Ben Liu,
Zhuanfang Wang
и другие.
Current Treatment Options in Oncology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 8, 2025
Язык: Английский
HER-2 positive gastric cancer: Current targeted treatments
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
274, С. 133247 - 133247
Опубликована: Июнь 19, 2024
Язык: Английский
Targeting LINC00665/miR-199b-5p/SERPINE1 axis to inhibit trastuzumab resistance and tumorigenesis of gastric cancer via PI3K/AKt pathway
Non-coding RNA Research,
Год журнала:
2024,
Номер
10, С. 153 - 162
Опубликована: Июль 31, 2024
Long
noncoding
RNAs
(lncRNAs)
serve
as
critical
mediators
of
tumor
progression
and
drug
resistance
in
cancer.
Herein,
we
identified
a
lncRNA,
LINC00665,
associated
with
trastuzumab
development
gastric
cancer
(GC).
LINC00665
was
highly
expressed
GC
tissues
high
expression
correlated
poor
prognosis.
knockdown
verified
to
suppress
migration,
invasion,
GC.
Furthermore,
found
that
participates
the
infiltration
naive
B
cells,
mast
T
follicular
helper
(Tfh)
cells.
Mechanistically,
confirmed
regulate
tumorigenesis
by
activating
PI3K/AKt
pathway.
sponged
miR-199b-5p
interact
SERPINE1
expression,
resulting
increase
phosphorylation
AKt,
thus
participating
To
summarize,
facilitated
sponging
promoting
which
further
activated
signaling;
this
finding
reveals
new
mechanism
modulates
Язык: Английский
A New Medical Evaluation for Gastric Cancer Patients to Increase the Success Rate of Immunotherapy: A 2024 Update
Pharmaceuticals,
Год журнала:
2024,
Номер
17(9), С. 1121 - 1121
Опубликована: Авг. 24, 2024
Researchers
have
performed
numerous
studies
on
immunotherapy
because
of
the
high
death
rate
associated
with
gastric
cancer
(GC).
GC
research
has
made
tremendous
progress,
and
we
wanted
to
provide
an
update
this
topic.
On
basis
update,
suggest
performing
a
new
medical
evaluation
before
initiating
in
patients
increase
success
immunotherapies.
We
propose
that
start
immunotherapy,
they
should
be
evaluated
given
score
one
two
points
for
following
factors:
immunopathological
features,
molecular
genomic
potential
consequences
bacterial
pathogens,
immunotherapeutic
resistance
hyperprogressive
illness,
use
biomarkers
gauge
their
prognosis
responses
optimize
surgery.
The
proposed
scoring
system
could
also
help
diagnosis
GC.
With
all
advances
genetics,
immunology,
microbiology,
improved,
not
changed.
Currently,
diagnosed
undergo
surgical
resection
as
only
permanent
solution.
Patients
who
meet
maximum
from
presented
proposal
eligible
immediately
after
immunotherapy.
Therefore,
first-line
option
clinicians.
Язык: Английский
Dronedarone hydrochloride inhibits gastric cancer proliferation in vitro and in vivo by targeting SRC
Translational Oncology,
Год журнала:
2024,
Номер
50, С. 102136 - 102136
Опубликована: Окт. 5, 2024
Язык: Английский
Deep learning application in prediction of cancer molecular alterations based on pathological images: a bibliographic analysis via CiteSpace
Yu Xiaojian,
Qu Zhanbo,
Jian Chu
и другие.
Journal of Cancer Research and Clinical Oncology,
Год журнала:
2024,
Номер
150(10)
Опубликована: Окт. 18, 2024
The
advancements
in
artificial
intelligence
(AI)
technology
for
image
recognition
were
propelling
molecular
pathology
research
into
a
new
era.
To
summarize
the
hot
spots
and
trends
field
of
recognition.
Relevant
articles
from
January
1st,
2010,
to
August
25th,
2023,
retrieved
Web
Science
Core
Collection.
Subsequently,
CiteSpace
was
employed
bibliometric
visual
analysis,
generating
diverse
network
diagrams
illustrating
keywords,
highly
cited
references,
topics,
trends.
A
total
110
relevant
extracted
pool
10,205
articles.
overall
publication
count
exhibited
rising
trend
each
year.
leading
contributors
terms
institutions,
countries,
authors
Maastricht
University
(11
articles),
United
States
(38
Kather
Jacob
Nicholas
(9
respectively.
Half
top
ten
based
on
volume,
affiliated
with
Germany.
most
frequently
article
authored
by
Nicolas
Coudray
et
al.
accumulating
703
citations.
keyword
"Deep
learning"
had
highest
frequency
2019.
Notably,
highlighted
keywords
2022
2023
included
"microsatellite
instability",
there
21
focusing
utilizing
algorithms
recognize
microsatellite
instability
(MSI)
colorectal
cancer
(CRC)
pathological
images.
use
DL
is
expected
provide
strategy
effectively
solve
current
problem
time-consuming
expensive
detection.
Therefore,
further
needed
address
issues,
such
as
data
quality
standardization,
model
interpretability,
resource
infrastructure
requirements.
Язык: Английский