Abstract
The
increasing
recognition
of
dietary
fiber’s
health
benefits
has
driven
extensive
research
in
this
area.
However,
with
the
growing
volume
studies,
tracking
emerging
trends
and
identifying
key
directions
can
be
challenging.
This
study
employs
CiteSpace
bibliometric
analysis
to
examine
21,434
articles
from
Web
Science
database,
providing
a
comprehensive
overview
fiber
2010
2024.
Major
outcomes
reveal
that
shown
steady
upward
trend,
particularly
last
five
years,
China
United
States
contributing
most
publications.
Canada,
however,
exhibits
highest
centrality
global
cooperation.
identifies
Nutrients
,
Foods
Food
Chemistry
as
top
journals
publishing
research.
Prolific
authors,
such
Gidley
Zhang,
along
leading
institutions
like
Consejo
Superior
de
Investigaciones
Cientificas
Department
Agriculture,
are
highlighted.
Keyword
co-occurrence
reveals
hotspots,
including
functional
characteristics
fiber,
its
relationship
intestinal
health,
application
foods.
Emerging
focus
on
development
new
fibers,
interaction
mechanisms
flora,
role
chronic
disease
prevention.
These
insights
offer
valuable
guidance
for
future
practical
applications
nutrition
health-related
industries.
Colorectal
cancer
(CRC)
remains
an
alarming
global
health
concern
despite
advancements
in
treatment
modalities
over
recent
decades.
Among
the
various
factors
contributing
to
CRC,
this
review
emphasizes
critical
role
of
epigenetic
mechanisms
its
pathogenesis
and
progression.
This
also
describes
potential
natural
compounds
altering
landscape,
focused
mainly
on
DNA
methylation,
histone
modification,
non-coding
RNAs.
Publications
from
previous
five
years
were
searched
retrieved
using
well-known
search
engines
databases
like
PubMed,
Google
Scholar,
ScienceDirect.
Keywords
CRC/colorectal
cancer,
CAC/Colitis
associated
inflammasomes,
modulation,
genistein,
curcumin,
quercetin,
resveratrol,
anthocyanins,
sulforaphane,
epigallocatechin-3-gallate
used
combinations
during
search.
These
predominantly
affect
pathways
such
as
Wnt/β-catenin,
NF-κB,
PI3K/AKT
suppress
CRC
cell
proliferation
oxidative
stress
enhance
anti-inflammation
apoptosis.
However,
their
clinical
use
is
restricted
due
low
bioavailability.
multiple
methods
exist
overcome
challenges
this,
including
but
not
limited
structural
modifications,
nanoparticle
encapsulations,
bio-enhancers,
novel
advanced
delivery
systems.
improve
supportive
therapies
that
target
progression
epigenetically
with
fewer
side
effects.
Current
research
focuses
enhancing
targeting
control
while
minimizing
effects,
emphasizing
improved
specificity,
bioavailability,
efficacy
standalone
or
synergistic
therapies.
Biomedicines,
Год журнала:
2025,
Номер
13(4), С. 990 - 990
Опубликована: Апрель 18, 2025
Estrogen
receptors
(ERs)
play
a
critical
role
in
breast
cancer
(BC)
development
and
progression,
with
ERα
being
oncogenic
ERβ
exhibiting
tumor-suppressive
properties.
The
interaction
between
ER
signaling
other
molecular
pathways,
such
as
PI3K/AKT/mTOR,
influences
tumor
growth
endocrine
resistance.
Emerging
research
highlights
the
of
prebiotics
modulating
gut
microbiota,
which
may
influence
estrogen
metabolism,
immune
function,
therapeutic
responses
BC.
This
review
explores
impact
on
receptor
modulation,
microbiota
composition,
regulation,
metabolic
pathways
cancer.
potential
adjunctive
therapies
to
enhance
treatment
efficacy
mitigate
chemotherapy-related
side
effects
is
discussed.
A
comprehensive
analysis
recent
preclinical
clinical
studies
was
conducted,
examining
reprogramming
short-chain
fatty
acids
(SCFAs)
derived
from
prebiotic
fermentation
epigenetic
regulation
resistance
also
evaluated.
Prebiotics
were
found
modulate
microbiota-estrogen
axis,
reduce
inflammation,
responses.
SCFAs
demonstrated
selective
downregulation
reprogramming,
suppressing
growth.
Synbiotic
interventions
effects,
improving
quality
life
patients.
offer
promising
avenue
for
prevention
therapy
by
pathways.
Future
trials
are
needed
validate
their
treatments
management.
Biomolecules,
Год журнала:
2025,
Номер
15(5), С. 688 - 688
Опубликована: Май 8, 2025
Chronic
inflammation
plays
a
crucial
role
in
cancer
development,
yet
the
mechanisms
linking
microbiome
to
inflammation-related
carcinogenesis
remain
unclear.
Emerging
evidence
suggests
that
microbiome-derived
metabolites
influence
inflammatory
pathways,
presenting
both
challenges
and
opportunities
for
therapy.
However,
deeper
understanding
of
how
these
regulate
contribute
prevention
is
still
needed.
This
review
explores
recent
advances
their
roles
carcinogenesis.
It
highlights
key
molecular
mechanisms,
emerging
therapies,
unresolved
challenges.
Synthesizing
current
research,
including
clinical
trials
experimental
models,
bridges
gap
between
science
Microbial
such
as
short-chain
fatty
acids
(SCFAs),
polyamines,
indoles,
bile
play
vital
regulating
suppressing
cancer.
Many
exhibit
potent
anti-inflammatory
immunomodulatory
effects,
demonstrating
therapeutic
potential.
Case
studies
show
promising
results,
but
metabolite
stability,
bioavailability,
individual
variability
remain.
Understanding
microbiome–metabolite
interactions
offers
novel
strategies
treatment.
identifies
knowledge
gaps
proposes
future
research
directions
harness
innovative
therapies.
Addressing
issues
may
pave
way
microbiome-targeted
interventions.
Abstract
The
increasing
recognition
of
dietary
fiber’s
health
benefits
has
driven
extensive
research
in
this
area.
However,
with
the
growing
volume
studies,
tracking
emerging
trends
and
identifying
key
directions
can
be
challenging.
This
study
employs
CiteSpace
bibliometric
analysis
to
examine
21,434
articles
from
Web
Science
database,
providing
a
comprehensive
overview
fiber
2010
2024.
Major
outcomes
reveal
that
shown
steady
upward
trend,
particularly
last
five
years,
China
United
States
contributing
most
publications.
Canada,
however,
exhibits
highest
centrality
global
cooperation.
identifies
Nutrients
,
Foods
Food
Chemistry
as
top
journals
publishing
research.
Prolific
authors,
such
Gidley
Zhang,
along
leading
institutions
like
Consejo
Superior
de
Investigaciones
Cientificas
Department
Agriculture,
are
highlighted.
Keyword
co-occurrence
reveals
hotspots,
including
functional
characteristics
fiber,
its
relationship
intestinal
health,
application
foods.
Emerging
focus
on
development
new
fibers,
interaction
mechanisms
flora,
role
chronic
disease
prevention.
These
insights
offer
valuable
guidance
for
future
practical
applications
nutrition
health-related
industries.
