Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 13, 2024
AbstractBackground:
Colorectal
cancer
(CRC)
is
a
prevalent
and
lethal
malignancy.
This
study
examines
differences
in
clinical
prognostic
characteristics
of
CRC
between
patients
under
50
years
those
aged
above,
treated
at
reference
hospital
Southern
Brazil.
Methods:
A
retrospective
cohort
was
conducted,
analyzing
data
from
the
Cancer
Hospital
Registry
Porto
Alegre,
RS.
Patients
diagnosed
with
colon
or
rectal
adenocarcinoma
January
2013
December
2017
were
included.
Variables
analyzed
included
family
history,
alcoholism,
smoking
status,
staging,
tumor
laterality,
presentation,
CEA
levels
diagnosis,
adjuvant
chemotherapy,
neutrophil-to-lymphocyte
ratio.
Results:
The
1,121
patients,
85%
older,
15%
younger
than
years.
Significant
observed
status
presenting
more
aggressive
disease
characteristics.
Conclusions:
Age
lifestyle
factors,
particularly
smoking,
significantly
influenced
presentation
management
colorectal
cancer.
These
findings
underscore
importance
targeted
prevention
strategies
personalized
treatment
approaches
for
patients.
Nutrients,
Год журнала:
2024,
Номер
16(8), С. 1161 - 1161
Опубликована: Апрель 13, 2024
Colorectal
cancer
stands
as
the
third
most
prevalent
form
of
worldwide,
with
a
notable
increase
in
incidence
Western
countries,
mainly
attributable
to
unhealthy
dietary
habits
and
other
factors,
such
smoking
or
reduced
physical
activity.
Greater
consumption
vegetables
fruits
has
been
associated
lower
colorectal
cancer,
which
is
attributed
their
high
content
fiber
bioactive
compounds,
flavonoids.
In
this
study,
we
have
tested
flavonoids
quercetin,
luteolin,
xanthohumol
potential
antitumor
agents
an
animal
model
induced
by
azoxymethane
dodecyl
sodium
sulphate.
Forty
rats
were
divided
into
four
cohorts:
Cohort
1
(control
cohort),
2
(quercetin
3
(luteolin
4
(xanthohumol
cohort).
These
administered
intraperitoneally
evaluate
pharmaceutical
agents.
At
end
experiment,
after
euthanasia,
different
parameters
intestinal
microbiota
populations
analyzed.
Luteolin
was
effective
significantly
reducing
number
tumors
compared
control
cohort.
Furthermore,
main
significant
differences
at
level
observed
between
cohort
treated
experienced
reduction
abundance
genera
disease
inflammatory
conditions,
Clostridia
UCG-014
Turicibacter.
On
hand,
healthy
state,
Muribaculum,
showed
luteolin
results
underline
anti-colorectal
manifested
through
modulation
tumors.
Diseases,
Год журнала:
2024,
Номер
12(4), С. 66 - 66
Опубликована: Март 26, 2024
This
systematic
review
investigates
the
intersection
of
early-onset
colorectal
cancer
(EOCRC),
sexual
functioning,
and
associated
quality
life
(QoL),
aiming
to
understand
comprehensive
impact
EOCRC
on
these
critical
dimensions.
Through
an
extensive
search
across
PubMed,
Scopus,
Embase
up
until
November
2023,
this
study
synthesized
evidence
from
literature
while
adhering
PRISMA
guidelines.
The
studies
included
patients
under
50
years,
which
examined
functioning
QoL
using
validated
instruments,
were
published
in
English.
After
a
rigorous
screening
process,
five
relevant
identified
initial
pool
2184
articles.
includes
data
involving
2031
patients.
key
findings
revealed
high
prevalence
dysfunction,
with
50%
men
experiencing
impotence
58%
reporting
alongside
36%
women
some
studies.
Pain
was
described
by
12%
31%
Anxiety
depression
notably
prevalent,
affecting
69%
participants.
profoundly
impacts
QoL,
significant
dysfunction
psychological
distress
among
affected
individuals.
These
suggest
need
for
oncological
management
strategies
that
include
not
only
medical
treatment
but
also
support
health
interventions.
emphasizes
importance
holistic
patient
care
approaches,
advocating
further
research
clinical
attention
address
complex
needs
younger
Nutrition and Cancer,
Год журнала:
2024,
Номер
76(9), С. 789 - 814
Опубликована: Июнь 18, 2024
Colorectal
cancer
(CRC)
is
one
of
the
major
causes
cancer-related
mortality
worldwide.
Despite
advances
in
treatment
modalities,
its
prevalence
continues
to
rise,
notably
among
younger
populations.
Unhealthy
dietary
habits,
sedentary
routines,
and
obesity
have
been
identified
as
key
contributors
development
colorectal
cancer,
apart
from
genetic
epigenetic
modifications.
Recognizing
profound
impact
diet
lifestyle
on
intricate
gut
microbiota
ecosystem
offers
a
promising
avenue
for
understanding
CRC
treatment.
Gut
dysbiosis,
characterized
by
imbalances
favoring
harmful
microbes
over
beneficial
ones,
has
emerged
defining
feature
CRC.
Changes
can
profoundly
alter
composition
metabolites
they
produce,
potentially
contributing
onset.
Focusing
recent
evidence,
this
review
discussed
various
factors,
such
high
consumption
red
processed
meats
low
fiber
intake,
including
obesity,
lack
physical
activity,
smoking,
excessive
alcohol
consumption,
that
influence
microbiome
elevate
risk.
Balkan Medical Journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 15, 2025
Colorectal
cancer
(CRC)
presents
an
enormous
burden
on
cancerrelated
deaths
and
ranks
third
in
cancer-associated
mortality
both
men
women
worldwide.
1CRC
develops
when
stem
cells
at
the
base
of
colon's
crypts
experience
genetic
epigenetic
alterations.Normal
become
cancerous
because
these
changes,
which
disrupts
delicate
balance
between
oncogenes
tumor
suppressor
genes.
1
Surgery,
chemotherapy,
radiation,
immunotherapy,
targeted
therapy
are
routine
therapies
for
CRC.Nonetheless,
depending
CRC
subtype,
prognosis
following
chemotherapy
varies
considerably.
2More
than
20%
incidences
linked
to
long-term
inflammation
often
observed
patients
with
inflammatory
bowel
disease
(IBD).This
type
CRC,
called
colitis-associated
colorectal
(CAC),
is
common
IBD.
BMC Gastroenterology,
Год журнала:
2025,
Номер
25(1)
Опубликована: Фев. 18, 2025
Colorectal
cancer
(CRC)
is
a
prevalent
and
lethal
malignancy.
This
study
examines
differences
in
clinical
prognostic
characteristics
of
CRC
between
patients
under
50
years
those
aged
above,
treated
at
reference
hospital
Southern
Brazil.
A
retrospective
cohort
was
conducted,
analyzing
data
from
the
Cancer
Hospital
Registry
Porto
Alegre,
RS.
Patients
diagnosed
with
colon
or
rectal
adenocarcinoma
January
2013
December
2017
were
included.
Variables
analyzed
included
family
history,
alcoholism,
smoking
status,
staging,
tumor
laterality,
presentation,
CEA
levels
diagnosis,
adjuvant
chemotherapy,
neutrophil-to-lymphocyte
ratio.
The
1,121
patients,
85%
older,
15%
younger
than
years.
Significant
observed
status
presenting
higher
prevalence
obstruction/subocclusion
which
may
reflect
presentation
due
to
delayed
diagnosis.
Age
lifestyle
factors,
particularly
smoking,
significantly
influenced
management
colorectal
cancer.
These
findings
underscore
importance
targeted
prevention
strategies
personalized
treatment
approaches
for
patients.
Frontiers in Oncology,
Год журнала:
2025,
Номер
15
Опубликована: Апрель 14, 2025
Colorectal
cancer
(CRC)
is
ranked
as
the
third
most
prevalent
malignancy
and
a
leading
cause
of
cancer-related
mortality
globally,
significantly
affecting
health
longevity
middle-aged
individuals
elderly.
The
primary
risk
factors
for
CRC
are
mainly
due
to
unhealthy
dietary
habits
lifestyle
choices,
they
have
been
shown
profoundly
influence
composition
gut
microbiota.
Given
that
patterns
critical
determinants
microbial
diversity,
compelling
association
exists
between
microbiota
pathogenesis
CRC.
Recent
research
has
increasingly
focused
on
intricate
interplay
CRC,
exploring
its
role
in
disease
initiation,
progression,
modulation
host
immune
responses.
Investigations
demonstrated
certain
specific
communities
can
promote
inflammation,
disrupt
metabolic
pathways,
produce
carcinogenic
compounds,
thereby
contributing
development
Conversely,
diverse
balanced
microbiome
may
confer
protective
effects
against
through
mechanisms
such
production
short-chain
fatty
acids
enhancement
intestinal
barrier
integrity.
This
article
provides
comprehensive
overview
characteristics
community
complex
relationship
with
It
highlights
potential
which
pathogenesis,
including
chronic
toxins,
metabolites,
epigenetic
dysregulation,
regulatory
dysfunction.
Additionally,
this
review
summarizes
innovative
strategies
prevention
treatment,
emphasizing
therapeutic
probiotics
natural
plant
extracts.
By
elucidating
these
connections,
work
aims
enhance
understanding
microbiome’s
Frontiers in Bioscience-Landmark,
Год журнала:
2025,
Номер
30(4)
Опубликована: Апрель 25, 2025
Background:
To
investigate
the
significance
of
negative
elongation
factor
complex
member
C/D
(NELFCD)
in
colon
cancer
progression.
Methods:
Immunohistochemistry
staining,
Western
blot
analysis,
and
real-time
quantitative
polymerase
chain
reaction
(RT-qPCR)
were
used
to
quantify
protein/gene
levels.
NELFCD-protein
arginine
methyltransferase
5
(PRMT5)
interaction
was
determined
by
co-immunoprecipitation
assay.
A
chromatin
immunoprecipitation
(ChIP)
assay
performed
determine
between
promoter
region
dual
specificity
phosphatase
2
(DUSP2),
NELFCD,
PRMT5.
Cell
growth
cell
cycle
progression
assessed
using
counting
kit-8
proliferation
assay,
colony
formation
and/or
flow
cytometry.
Results:
NELFCD
upregulated
promoted
growth.
In
cells,
expression
negatively
correlated
with
DUSP2
expression.
The
RNA
sequencing
results
indicated
that
genes
mitogen-activated
protein
kinase
(MAPK)
signaling
pathway
as
well
affected
NELFCD.
ChIP
revealed
MAPK
are
direct
targets
verified
PRMT5
is
enriched
at
overexpression
this
enrichment.
demonstrated
bound
PRMT5,
functioning
a
macromolecular
complex.
Conclusions:
This
study
suggests
promotes
recruiting
inhibit
expression,
which
subsequently
activates
p38
pathway.
Targeting
NELFCD–DUSP2–p38
axis
may
be
promising
therapeutic
intervention
for
patients
suffering
from
NELFCD-amplified
tumors.
