Current Opinion in Supportive and Palliative Care,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 9, 2024
Purpose
of
review
Advances
in
oncological
therapies
have
resulted
an
increase
the
number
patients
living
with
and
beyond
cancer.
The
personal
societal
impact
chronic
pain
survivor
population
represents
area
significant
unmet
need.
Capsaicin
(a
TRPV1
agonist)
may
provide
analgesia
limited
systemic
side
effects.
This
looks
to
summarise
most
recent
evidence
regarding
use
capsaicin
management
cancer
pain.
Recent
findings
Various
international
guidelines
recently
endorsed
high
concentration
patches
treatment
painful
chemotherapy
induced
peripheral
neuropathy.
Numerous
studies
support
neuropathic
promising
data
is
predominantly
yielded
from
secondary
herpes
zoster
diabetic
neuropathy,
expanding
but
small
base
for
its
utility
other
pains.
Emerging
suggests
that
treatments
are
better
tolerated
more
rapidly
when
compared
treatments.
Summary
Whilst
randomised
controlled
trial
lacking,
large
cohort
studies,
guidelines,
a
wide
variety
Heliyon,
Год журнала:
2024,
Номер
10(11), С. e32390 - e32390
Опубликована: Июнь 1, 2024
A
form
of
cancer
that
affects
the
rectum
or
colon
(large
intestine)
is
called
colorectal
(CRC).
The
main
risk
factors
for
CRC
include
dietary,
lifestyle,
and
environmental
variables.
Currently
natural
polyphenols
have
demonstrated
impressive
anticarcinogenic
capabilities.
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
173, С. 116363 - 116363
Опубликована: Март 12, 2024
Ferroptosis,
a
novel
form
of
regulated
cell
death
characterized
by
dependence
on
iron
and
lipid
peroxidation,
has
been
implicated
in
wide
range
clinical
conditions
including
neurological
diseases,
cardiovascular
disorders,
acute
kidney
failure,
various
types
cancer.
Therefore,
it
is
critical
to
suppress
cancer
progression
proliferation.
Ferroptosis
can
be
triggered
cells
some
normal
synthetic
substances,
such
as
erastin,
Ras-selective
lethal
small
molecule-3,
or
pharmaceuticals.
Natural
bioactive
compounds
are
traditional
drug
discovery
tools,
have
therapeutically
used
dietary
additives
pharmaceutical
agents
against
malignancies.
The
fact
that
natural
products
multiple
targets
minimal
side
effects
led
notable
advances
anticancer
research.
Research
indicated
ferroptosis
also
induced
during
treatment.
In
this
review,
we
focused
the
most
recent
developments
emerging
molecular
processes
significance
To
provide
new
perspectives
future
development
ferroptosis-related
medications,
summary
implications
phytochemicals
triggering
through
ROS
production
ferritinophagy
induction
variety
Frontiers in Nutrition,
Год журнала:
2025,
Номер
12
Опубликована: Фев. 4, 2025
Attention
deficit
hyperactivity
disorder
(ADHD)
is
a
common
neurodevelopmental
disorder,
which
characterized
by
inattention,
impulsivity
and
hyperactivity.
Although
the
etiology
pathogenesis
of
ADHD
are
not
fully
understood,
existing
studies
have
shown
that
it
may
be
related
to
genetic
factors,
environmental
abnormal
brain
development,
psychosocial
factors.
In
recent
years,
with
concept
microbioa-gut-brain
axis
(MGBA),
more
begun
pay
attention
effect
gut
microbiota
on
ADHD.
Dietary
structure
can
significantly
change
diversity
abundance
microbiota.
Therefore,
dietary
supplements
or
food
additives
regulate
become
one
potential
ways
treat
Peppers,
as
an
important
component,
value
in
regulating
Among
them,
capsaicin
(8-methyl
N-vanillyl-6-noneamide,
CAP),
key
active
component
peppers,
has
been
therapeutic
effects
central
nervous
system
(CNS)
diseases
such
Parkinson’s
disease,
epilepsy,
depression.
addition,
much
paid
beneficial
CAP
Chili
peppers
contain
only
CAP,
but
also
rich
vitamin
C
fatty
acids,
all
ameliorate
modulating
This
finding
provides
treatment
for
ADHD,
new
perspective
expand
research
clinical
pathogenesis.
current
chili
still
at
early
stage
requires
further
verification
through
larger-scale
rigorous
controlled
studies,
its
cannot
ignored.
Molecules,
Год журнала:
2024,
Номер
29(12), С. 2843 - 2843
Опубликована: Июнь 14, 2024
Background:
This
work
proposes
the
development
of
new
vesicular
systems
based
on
anesthetic
compounds
(lidocaine
(LID)
and
capsaicin
(CA))
antimicrobial
agents
(amino
acid-based
surfactants
from
phenylalanine),
with
a
focus
physicochemical
characterization
evaluation
cytotoxic
properties.
Method:
Phenylalanine
were
characterized
via
high-performance
liquid
chromatography
(HPLC)
nuclear
magnetic
resonance
(NMR).
Different
niosomal
capsaicin,
lidocaine,
cationic
phenylalanine
surfactants,
dipalmitoyl
phosphatidylcholine
(DPPC)
in
terms
size,
polydispersion
index
(PI),
zeta
potential,
encapsulation
efficiency
using
dynamic
light
scattering
(DLS),
transmitted
microscopy
(TEM),
small-angle
X-ray
(SAXS).
Furthermore,
interaction
pure
used
to
prepare
formulations
DPPC
monolayers
was
determined
Langmuir
balance.
The
antibacterial
activity
their
biocompatibility
evaluated,
molecular
docking
studies
carried
out
obtain
information
about
mechanism
by
which
these
interact
bacteria.
Results:
stability
reduced
size
analyzed
demonstrate
potential
pharmaceutical
applications.
nanosystems
exhibit
promising
activity,
marking
significant
advancement
delivery
dual
therapeutic
some
underscores
viability.
Conclusions:
proposed
could
constitute
an
important
advance
field,
offering
for
combined
therapies
thanks
pharmacological
properties
individual
components.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(16), С. 8979 - 8979
Опубликована: Авг. 18, 2024
Chronic
low-grade
inflammation
(CLGI)
is
associated
with
obesity
and
one
of
its
pathogenetic
mechanisms.
Lipopolysaccharide
(LPS),
a
component
Gram-negative
bacterial
cell
walls,
the
principal
cause
CLGI.
Studies
have
found
that
capsaicin
significantly
reduces
relative
abundance
LPS-producing
bacteria.
In
present
study,
Toxins,
Год журнала:
2024,
Номер
16(11), С. 489 - 489
Опубликована: Ноя. 12, 2024
Scientists
are
becoming
alarmed
by
the
rise
in
drug-resistant
bacterial
and
fungal
strains,
which
makes
it
more
costly,
time-consuming,
difficult
to
create
new
antimicrobials
from
unique
chemical
entities.
Chemicals
with
pharmacological
qualities,
such
as
antibacterial
antifungal
elements,
can
be
found
plants.
Alkaloids
a
class
of
compounds
nature
that
mostly
consist
basic
nitrogen
atoms.
Biomedical
science
relies
heavily
on
alkaloid
compounds.
Based
241
papers
published
peer-reviewed
scientific
publications
within
last
ten
years
(2014–2024),
we
examined
248
natural
or
synthesized
monomeric
alkaloids
have
activity
against
Gram-positive
Gram-negative
microorganisms.
their
structure,
chosen
were
divided
into
four
groups:
polyamine
alkaloids,
side
chain,
heterocycles,
pseudoalkaloids.
With
MIC
values
less
than
1
µg/mL,
91,
124,
125,
136–138,
163,
164,
191,
193,
195,
205
206
shown
strong
activity.
However,
below
207,
224
demonstrated
Given
antibiotic
resistance,
these
highly
significant
regard
potential
novel
antimicrobial
drugs.
