Archives of Oral Biology, Год журнала: 2024, Номер 169, С. 106122 - 106122
Опубликована: Окт. 30, 2024
Язык: Английский
BMC Oral Health, Год журнала: 2024, Номер 24(1)
Опубликована: Июль 26, 2024
Abstract Background Epidemiological studies have demonstrated that periodontitis is an independent risk factor for chronic obstructive pulmonary disease (COPD). However, the mechanism underlying association between these two diseases remains unclear. The lung microbiota shares similarities with oral microbiota, and there growing evidence to suggest microbiome could play a role in pathogenesis of COPD. This study aimed investigate whether periodontal pathogens contribute COPD mouse model. Methods We established models infection by typical pathogens, porphyromonas gingivalis (Pg group) or fusobacterium nucleatum (Fn group), over three-month period. Mice did not receive were set as control group (C group). assessed level alveolar bone resorption, function, histological changes lungs mice. Additionally, we measured levels inflammatory factors tissue damage associated tissues. Results Lung function indices, including airway resistance, peak inspiratory/expiratory flow expiratory flow-50%, significantly reduced Fn compared C group. examination revealed increased number cells bullae formation sections Meanwhile, such IL-1β, IL-6, IFN-γ, TNF-α, well like matrix metalloproteinase-8 neutrophil elastase, elevated comparison Pg also showed similar but milder be detected both infected groups. Conclusion results indicated induce COPD-like mice, they may biological
Язык: Английский
Процитировано
6
Biocatalysis and Agricultural Biotechnology, Год журнала: 2024, Номер 61, С. 103406 - 103406
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
3
Expert Review of Respiratory Medicine, Год журнала: 2025, Номер unknown
Опубликована: Апрель 14, 2025
Ventilator-associated pneumonia (VAP), defined as a lung infection that occurs in patients after 48 hours on mechanical ventilation, is among the most frequently found nosocomial infections intensive care units around world and associated with increased morbidity, mortality, economic burden. We review classical mechanisms of VAP development explore more recent ones, such dysbiosis, which has changed our view pathogenesis disease; whereas past lower respiratory tract was classically considered sterile organ, use new diagnostic techniques shown lungs healthy humans are inhabited by large, dynamic ecosystem microorganisms. Dysbiosis disruption this key factor VAP. Recent findings have demonstrated host immunity microbiome-regulated and, consequently, profoundly affected dysbiosis. In paper significance microbiome-immunity crosstalk pathophysiology will be discussed. A deeper understanding should help to devise preventive, therapeutic strategies for reducing incidence condition improving patient prognosis.
Язык: Английский
Процитировано
0
Meditsinskiy sovet = Medical Council, Год журнала: 2024, Номер 13, С. 270 - 278
Опубликована: Сен. 1, 2024
At the beginning of 21st century, concept “periodontal medicine” was formed, within framework which bidirectional connection periodontal pathology with systemic diseases body is considered. There are two hypotheses regarding possibility chronic infection to contribute development inflammation: 1) changes in microbiocenosis oral cavity and inflammation lead an increase bacterial translocation into bloodstream, causing circulation inflammatory mediators immune complexes other organs systems body; 2) can disturbances intestinal microbiome due intake periodontopathic organisms. The relationship between respiratory has been less studied. We searched Pubmed Scopus databases for articles published up January 31, 2024, that addressed this relationship. proximity continuity tract allows be a major determinant pulmonary microbiome. It possible distinguish 2 main ways bacteria lungs - aerogenic aspiration. data presented review suggest probable hospital-acquired pneumonia, new coronavirus COVID-19, COPD. BA considered possible, but number studies not confirmed, requires further study. community-acquired pneumonia practically studied, it taking account direct interaction microbiota along mouth-lung axis, indirectly mouth-intestinal-lung axis. Non-surgical treatment likely effective prevention diseases. indicate importance health need periodontitis patients.
Язык: Английский
Процитировано
0
Sci, Год журнала: 2024, Номер 6(4), С. 57 - 57
Опубликована: Сен. 27, 2024
Periodontitis is characterized by gingival regression, alveolar bone resorption and the development of deep periodontal pockets that, if left untreated, can lead to tooth loss. Currently, specific biomarkers are needed for early, objective diagnosis, monitoring, management patients. In this proteomic study, pocket tissues from patients with severe periodontitis were analyzed in comparison periodontally healthy sites aim discovering distinctive protein targets. Gingival fragmented using a motorized mechanical method mixture was separated via mono-dimensional gel electrophoresis. The examination bands definite 1D image analysis software allowed detection 22 differentially expressed proteins between pathological samples that identified through mass spectrometry. A comparative assessment these those previously reported other studies conducted on diseases various types oral specimens, such as crevicular fluid, dentin, pulp, root canal content, salivary gland secretions, saliva, ligament cells, dental stem highlighted great number significant common matches. discovery selective cluster periodontitis-related could become particularly important before clinical manifestation disease promptly stop its progression timely preventive diagnosis.
Язык: Английский
Процитировано
0
Archives of Oral Biology, Год журнала: 2024, Номер 169, С. 106122 - 106122
Опубликована: Окт. 30, 2024
Язык: Английский
Процитировано
0