Biomedicines, Год журнала: 2024, Номер 12(10), С. 2370 - 2370
Опубликована: Окт. 17, 2024
: We aimed to explore the correlation between thyroid function and diabetic kidney disease (DKD) in patients with type 2 diabetes mellitus (T2DM).
Язык: Английский
Natural Product Communications, Год журнала: 2025, Номер 20(2)
Опубликована: Фев. 1, 2025
Diabetic nephropathy (DN) is the leading cause of uremia and clinical mortality, characterized by progressive deterioration kidney structure function due to prolonged exposure hyperglycemia. This condition often necessitates renal replacement therapy for patients with end-stage-renal-disease (ESRD). Consequently, early detection, diagnosis, treatment DN are crucial mitigate disease progression, enhance patient outcomes, maintain a good quality life. Exploring relevant biomarkers diagnosis holds significant importance. In recent years, numerous researchers have identified various novel associated diabetic nephropathy, which critical predicting both onset progression disease. article aims provide comprehensive overview related DN.
Язык: Английский
Процитировано
0
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Апрель 1, 2025
Diabetic nephropathy (DN) is one of the severe complications diabetes, current treatment against DN still limited. It suggested that gut microbiota metabolites will be a promising alternative therapy DN. In this study, we explore beneficial effect on via employing network pharmacology study. The targets were screen from Similarity Ensemble Approach (SEA) and Swiss Target Prediction (STP). acquired disease database. intersecting considered crucial targets. Protein–Protein Interaction (PPI) networks, GO function KEGG analysis conducted to identify core target key signaling pathway. A "Microbiota-Substrate-Metabolites-Targets" was built metabolites. Molecular docking employed assess binding affinity between functional results indicated mainly enriched in oxidative stress inflammation. PPARG, AKT1, IL6 JUN top 4 regulating Butyrate, Acetate, Indole 3-Indolepropionic acid had effects attenuating displayed good toward JUN. Our study revealed might exert by multi-signaling pathway multi-targets. This work offers us novel insight into mechanism perspective benefits
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(18), С. 10044 - 10044
Опубликована: Сен. 18, 2024
Identification of the individuals having impaired kidney function is essential in preventing complications this disease. We measured 1009 metabolites at baseline study 10,159 Finnish men METSIM cohort and associated with an estimated glomerular filtration rate (eGFR). A total 7090 participated 12-year follow-up study. Non-targeted metabolomics profiling was performed Metabolon, Inc. (Morrisville, NC, USA) on EDTA plasma samples obtained after overnight fasting. applied liquid chromatography mass spectrometry (LC-MS/MS) to identify (the Metabolon DiscoveryHD4 platform). association analyses between eGFR using linear regression adjusted for confounding factors. found 108 significantly a decrease eGFR, 28 them were novel, including 12 amino acids, 8 xenobiotics, 5 lipids, 1 nucleotide, peptide, partially characterized molecule. The most significant associations five N-acetylmethionine, N-acetylvaline, gamma-carboxyglutamate, 3-methylglutaryl-carnitine, pro-line. identified novel decreased cohort. These findings provide insights into role metabolic pathways involved decline function.
Язык: Английский
Процитировано
0
Biomedicines, Год журнала: 2024, Номер 12(10), С. 2370 - 2370
Опубликована: Окт. 17, 2024
: We aimed to explore the correlation between thyroid function and diabetic kidney disease (DKD) in patients with type 2 diabetes mellitus (T2DM).
Язык: Английский
Процитировано
0