Protocatechuic Acid Alleviates Inflammation and Oxidative Stress in Acute Respiratory Distress Syndrome by Promoting Unconventional Prefoldin RPB5 Interactor 1‐Mediated Mitophagy DOI Open Access
Xianyong Li,

Quankuan Gu,

Jiaxi Xu

и другие.

Chemical Biology & Drug Design, Год журнала: 2025, Номер 105(3)

Опубликована: Март 1, 2025

ABSTRACT Protocatechuic acid (PCA) is a type of polyphenol with diverse biological activities, including antioxidant and anti‐inflammatory properties. This study aimed to explore the function PCA in acute respiratory distress syndrome (ARDS) delve into its functional mechanism. Lipopolysaccharides were applied stimulate human pulmonary microvascular endothelial cells (HPMECs) or C57BL/6 mice generate ARDS models vitro vivo. treatment (300 μM for 20 30 mg/kg mice) reduced proinflammatory cytokine production oxidative stress HPMECs mouse models, it cell apoptosis while alleviating alveolar septum thickening. Chromobox 4 (CBX4) was identified as target protein PCA, found activate transcription unconventional prefoldin RPB5 interactor 1 (URI1) by recruiting histone acetyltransferase general control nondepressible 5 (GCN5) promoter region. CBX4 URI1 levels LPS but restored PCA. Knockdown either negated ameliorating effects on LPS‐induced inflammation diminished promoting roles mitochondrial biogenesis mitophagy. suggests that holds promise CBX4/URI1‐mediated

Язык: Английский

Protocatechuic Acid Alleviates Inflammation and Oxidative Stress in Acute Respiratory Distress Syndrome by Promoting Unconventional Prefoldin RPB5 Interactor 1‐Mediated Mitophagy DOI Open Access
Xianyong Li,

Quankuan Gu,

Jiaxi Xu

и другие.

Chemical Biology & Drug Design, Год журнала: 2025, Номер 105(3)

Опубликована: Март 1, 2025

ABSTRACT Protocatechuic acid (PCA) is a type of polyphenol with diverse biological activities, including antioxidant and anti‐inflammatory properties. This study aimed to explore the function PCA in acute respiratory distress syndrome (ARDS) delve into its functional mechanism. Lipopolysaccharides were applied stimulate human pulmonary microvascular endothelial cells (HPMECs) or C57BL/6 mice generate ARDS models vitro vivo. treatment (300 μM for 20 30 mg/kg mice) reduced proinflammatory cytokine production oxidative stress HPMECs mouse models, it cell apoptosis while alleviating alveolar septum thickening. Chromobox 4 (CBX4) was identified as target protein PCA, found activate transcription unconventional prefoldin RPB5 interactor 1 (URI1) by recruiting histone acetyltransferase general control nondepressible 5 (GCN5) promoter region. CBX4 URI1 levels LPS but restored PCA. Knockdown either negated ameliorating effects on LPS‐induced inflammation diminished promoting roles mitochondrial biogenesis mitophagy. suggests that holds promise CBX4/URI1‐mediated

Язык: Английский

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