Recent Advancements in Strategies for the Synthesis of Imidazoles, Thiazoles, Oxazoles, and Benzimidazoles
ChemistrySelect,
Год журнала:
2023,
Номер
8(47)
Опубликована: Дек. 13, 2023
Abstract
Nitrogen‐containing
heterocycles
such
as
imidazoles,
thiazoles,
and
oxazoles
play
a
significant
role
in
the
fields
of
biological
pharmaceutical
chemistry.
These
compounds
were
widely
used
for
agrochemical,
pesticide,
medicinal,
industrial
applications.
Due
to
wide
spectrum
structural
diversity
well
activity
N
‐heterocycles,
plethora
reports
on
their
synthesis
have
appeared
last
few
decades.
However,
developments
various
bond‐forming
strategies
C−C,
C−N,
C−O,
C−S,
N−N,
C−H
activation,
been
powerful
synthetic
tool
derive
copious
‐heterocycles.
The
most
prominent
fascinating
imidazole,
thiazole,
oxazoles,
benzimidazole
moieties
by
C−C
C−N
coupling
reactions,
multi‐component
cycloaddition
etc.
are
discussed
this
study.
studies
demonstrated
enormous
potential
methods
accelerating
modern
chemical
establishing
molecular
beauty
through
bonding.
aspects
methodologies,
like
optimized
conditions,
substrate
scope,
mechanistic
investigations,
detail.
Язык: Английский
Organocatalytic Approaches towards the Synthesis of Asymmetric Tetrahydroquinoline (THQ) Derivatives
Synthesis,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 30, 2024
Abstract
1,2,3,4-Tetrahydroquinolines
(THQs)
are
present
in
molecules
with
significant
biological
importance
and
pharmaceuticals
diverse
activities.
Various
synthetic
routes
have
been
developed
to
tetrahydroquinolines,
such
as
the
hydrogenation
of
quinolines,
domino
reactions,
intramolecular
cyclization,
notably,
Povarov
reaction.
Organocatalysts
small,
chiral
organic
that
can
successfully
catalyze
transformations.
This
review
examines
use
organocatalysts
asymmetric
synthesis
tetrahydroquinoline
derivatives
using
aminocatalysis,
NHC
catalysis,
H-bonding
catalysis
covering
literature
between
2000
early
2024.
1
Introduction
2
Aminocatalysis
3
Catalysis
4
H-Bonding
5
Miscellaneous
6
Conclusion
Язык: Английский
Comprehensive Strategies for the Synthesis of 1,3-Enyne Derivatives
Synthesis,
Год журнала:
2024,
Номер
unknown
Опубликована: Май 1, 2024
Abstract
The
synthesis
of
1,3-enyne
has
widespread
appeal
in
organic
due
to
their
proven
adaptability
as
intermediates
routes
compounds
significant
biological
and
material
interest.
A
variety
methods
have
been
designed
formulate
1,3-enynes
from
diverse
substrates,
such
alkynes,
1,3-diynes,
alkynyl-substituted
cyclopropanes,
propargyl
alcohols.
This
review
covers
the
utilizing
homo-
cross-coupling
nucleophilic
metal/acid-induced
cyclopropane
ring
opening,
rearrangement/dehydration
key
concern
procedures
starting
alkynes
1,3-diynes
is
management
regio-,
stereo-,
and,
where
fitting,
chemoselectivity.
In
contrast,
cyclopropyl
opening
nucleophile
orientation
determines
formed.
Efficient
for
broad
selective
are
highlighted
specific
examples
given
demonstrate
efficacy
these
processes.
1
Introduction
Scope
2
Synthesis
2.1
1,3-Enynes
Alkynes
2.1.1
Metal-Catalyzed
Cross-Coupling/Additions
with
Alkenes
or
Vinyl
Aryl
Halides
2.1.1.1
Palladium
Catalysis
2.1.1.2
Rhodium
2.1.1.3
Copper
2.1.1.4
I
ron
2.1.1.5
Nickel
2.1.1.6
Miscellaneous
2.2
Enynes
Propargyl
Alcohols
2.3
Metal/Acid-Catalyzed
Ring
Opening
Cyclopropanes
3
Conclusion
Язык: Английский