Formulation and Characterization of Novel Non-Ionic Surfactant Based Aceclofenac Gel as a Potential Drug Delivery System DOI Open Access
Mamta Kumari, Piyushkumar Sadhu,

Dipti Gohil

и другие.

Journal of Pharmaceutical Research International, Год журнала: 2021, Номер unknown, С. 176 - 187

Опубликована: Июль 10, 2021

Background: Aceclofenac is considered to the first line drug in symptomatic treatment of rheumatoid arthritis, osteoartheritis and ankylosing spondylitis. The successful arthritis depend on maintenance effective concentration level body, for which a constant uniform supply desired. short biological half-life (about 4 hrs) dosing frequency more than once day as well (70-80%) dose excreted by renal transport make aceclofenac an ideal candidate formulation niosomal gel. Methodology: gel order sustain release topically, decreases side effect GI disturbance maintaining blood decrease excretion dosing. Niosomal was prepared coacervation phase separation method. Preformulation studies, structural analysis, in-vitro study, mechanism kinetic data analysis (zero order, higuchi’s model), percentage entrapment efficiency stability study were performed (n=3). Anti-Inflammatory final optimized formulation. Result conclusion: It revealed from preformulation studies that materials obtained did not show any incompatibility. Particle size determined range 9.46±1.055 12.91±3.587μm using optical microscope with calibrated eyepiece micrometer. Scanning Electron Microscopy niosomes observe surface morphology reported 63.49±0.265% 78.55±0.425%. From modelling, it analysed released diffusion-controlled mechanism. Lastly, all formulations done two different temperature anti inflammatory activity optimised compared marketed (Voveran Emulgel). Results shows showed fair anti-inflammatory but good commercial product.

Язык: Английский

Formulation and Characterization of Novel Non-Ionic Surfactant Based Aceclofenac Gel as a Potential Drug Delivery System DOI Open Access
Mamta Kumari, Piyushkumar Sadhu,

Dipti Gohil

и другие.

Journal of Pharmaceutical Research International, Год журнала: 2021, Номер unknown, С. 176 - 187

Опубликована: Июль 10, 2021

Background: Aceclofenac is considered to the first line drug in symptomatic treatment of rheumatoid arthritis, osteoartheritis and ankylosing spondylitis. The successful arthritis depend on maintenance effective concentration level body, for which a constant uniform supply desired. short biological half-life (about 4 hrs) dosing frequency more than once day as well (70-80%) dose excreted by renal transport make aceclofenac an ideal candidate formulation niosomal gel. Methodology: gel order sustain release topically, decreases side effect GI disturbance maintaining blood decrease excretion dosing. Niosomal was prepared coacervation phase separation method. Preformulation studies, structural analysis, in-vitro study, mechanism kinetic data analysis (zero order, higuchi’s model), percentage entrapment efficiency stability study were performed (n=3). Anti-Inflammatory final optimized formulation. Result conclusion: It revealed from preformulation studies that materials obtained did not show any incompatibility. Particle size determined range 9.46±1.055 12.91±3.587μm using optical microscope with calibrated eyepiece micrometer. Scanning Electron Microscopy niosomes observe surface morphology reported 63.49±0.265% 78.55±0.425%. From modelling, it analysed released diffusion-controlled mechanism. Lastly, all formulations done two different temperature anti inflammatory activity optimised compared marketed (Voveran Emulgel). Results shows showed fair anti-inflammatory but good commercial product.

Язык: Английский

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