Modulation of the Neuro–Cancer Connection by Metabolites of Gut Microbiota
Biomolecules,
Год журнала:
2025,
Номер
15(2), С. 270 - 270
Опубликована: Фев. 12, 2025
The
gut-brain-cancer
axis
represents
a
novel
and
intricate
connection
between
the
gut
microbiota,
neurobiology,
cancer
progression.
Recent
advances
have
accentuated
significant
role
of
microbiota
metabolites
in
modulating
systemic
processes
that
influence
both
brain
health
tumorigenesis.
This
paper
explores
emerging
concept
metabolite-mediated
modulation
within
connection,
focusing
on
key
such
as
short-chain
fatty
acids
(SCFAs),
tryptophan
derivatives,
secondary
bile
acids,
lipopolysaccharides
(LPS).
While
microbiota's
impact
immune
regulation,
neuroinflammation,
tumor
development
is
well
established,
gaps
remain
grasping
how
specific
contribute
to
neuro-cancer
interactions.
We
discuss
with
potential
implications
for
neurobiology
cancer,
indoles
polyamines,
which
yet
be
extensively
studied.
Furthermore,
we
review
preclinical
clinical
evidence
linking
dysbiosis,
altered
metabolite
profiles,
tumors,
showcasing
limitations
research
gaps,
particularly
human
longitudinal
studies.
Case
studies
investigating
microbiota-based
interventions,
including
dietary
changes,
fecal
transplantation,
probiotics,
demonstrate
promise
but
also
indicate
hurdles
translating
these
findings
therapies.
concludes
call
standardized
multi-omics
approaches
bi-directional
frameworks
integrating
microbiome,
neuroscience,
oncology
develop
personalized
therapeutic
strategies
patients.
Язык: Английский
The Gut-Brain Axis in Neurodevelopmental Disorders: Mechanistic Insights, Clinical Implications, and Public Health Strategies
European Journal of Theoretical and Applied Sciences,
Год журнала:
2024,
Номер
2(6), С. 580 - 596
Опубликована: Ноя. 1, 2024
The
integration
of
gut
microbiota
research
into
the
understanding
and
treatment
neurodevelopmental
disorders
has
profound
implications
for
both
clinical
practice
public
health.
microbial
community’s
influence
on
neural
development
through
mechanisms
such
as
metabolites,
immune
regulation,
gene
expression
underscores
complexity
like
autism
spectrum
disorder
(ASD)
attention-deficit
hyperactivity
(ADHD).
As
continues
to
unravel
intricate
relationship
between
brain
function,
innovative
therapeutic
interventions,
including
probiotics,
prebiotics,
fecal
transplantation,
hold
potential
improve
symptoms
outcomes.
However,
safety
long-term
effectiveness
these
therapies
remain
critical
areas
future
investigation.
Advances
in
diagnostic
tools
personalized
medicine,
which
incorporate
biomarkers,
offer
exciting
prospects
early
detection
tailored
treatments,
ultimately
improving
quality
life
individuals
with
disorders.
Continued
interdisciplinary
collaboration
is
essential
translating
findings
practical
solutions
that
address
underlying
complex
This
review
highlights
role
disorders,
emphasizing
importance
genetic
interactions
shaping
development.
Язык: Английский