The role of DGAT1 and DGAT2 in tumor progression via fatty acid metabolism: A comprehensive review
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
278, С. 134835 - 134835
Опубликована: Авг. 22, 2024
Fatty
acid
metabolism
is
a
complex
biochemical
process,
including
the
production,
breakdown
and
application
of
fatty
acids.
Not
only
it
an
important
component
lipid
metabolism,
also
connected
to
energy
pathways
cells
plays
vital
role
in
maintaining
balance
organisms.
Diacylglycerol-O-acyltransferase
1
(DGAT1)
2
(DGAT2)
are
key
components
regulating
which
provide
for
cell
proliferation
growth.
Recent
studies
have
shown
that
DGAT1
DGAT2
influence
tumor
progression
through
cancer.
Although
similar
names,
they
differ
significantly
various
aspects
play
distinct
roles
individual
tumors.
A
comparative
analysis
physiological
these
enzymes
their
differential
expressions
different
types
tumors
will
enhance
our
understanding
unique
characteristics.
This
article
summarizes
characteristics
explains
how
specifically
promote
progression.
In
addition,
this
review
discusses
potential
lipid-lowering
drugs
treatment,
providing
new
perspective
on
targeting
inhibit
future,
while
emphasizing
importance
as
targets
treatment.
Язык: Английский
Triterpenoids from Ilicis Rotundae Cortex ameliorate hyperlipidemia by affecting bile acids-hepatointestinal FXR axis
Phytomedicine,
Год журнала:
2025,
Номер
139, С. 156537 - 156537
Опубликована: Фев. 20, 2025
Язык: Английский
Targeting of AMPK/MTOR signaling in the management of atherosclerosis: Outmost leveraging
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
309, С. 142933 - 142933
Опубликована: Апрель 8, 2025
Язык: Английский
Fenofibrate promotes erucic acid (EA) metabolism by peroxisome enzyme EHHADH activation alleviating HFD-induced steatotic liver disease
Molecular Pharmacology,
Год журнала:
2025,
Номер
unknown, С. 100047 - 100047
Опубликована: Май 1, 2025
Язык: Английский
Fenofibrate to prevent amputation and reduce vascular complications in patients with diabetes: FENO-PREVENT
Cardiovascular Diabetology,
Год журнала:
2024,
Номер
23(1)
Опубликована: Сен. 3, 2024
Abstract
Background
The
potential
preventive
effect
of
fenofibrate
on
lower
extremity
amputation
(LEA)
and
peripheral
arterial
disease
(PAD)
in
patients
with
type
2
diabetes
(T2D)
is
not
fully
elucidated.
Methods
We
selected
adult
≥
20
years
age
T2D
from
the
Korean
National
Health
Insurance
Service
Database
(2009–2012).
users
were
matched
a
1:4
ratio
non-users
using
propensity
scores
(PS).
outcome
variables
composite
LEA
PAD
individual
components.
risks
outcomes
implemented
as
hazard
(HR)
95%
confidence
intervals
(CI).
For
safety
issues,
acute
kidney
injury,
rhabdomyolysis
resulting
hospitalization
analyzed.
Results
A
total
114,920
was
included
analysis
median
follow-up
duration
7.6
(22,984
91,936
for
user
non-user
groups,
respectively).
After
PS
matching,
both
groups
well
balanced.
group
associated
significantly
(HR
0.81;
CI
0.70–0.94),
0.76;
0.60–0.96),
0.68–0.96).
risk
rhabdomyolysis,
or
these
events
showed
no
significant
difference
between
two
groups.
Subgroup
analyses
revealed
consistent
benefits
across
genders,
baseline
lipid
profiles.
Conclusions
This
nationwide
population-based
retrospective
observational
study
suggests
that
can
prevent
who
are
statin
therapy.
Язык: Английский
An exploratory investigation of lipid-lowering potential of spirulina ( Arthrospira platensis ) targeting apoprotein-E in chronic hyperlipidemic wistar albino rats
Cogent Food & Agriculture,
Год журнала:
2024,
Номер
10(1)
Опубликована: Ноя. 3, 2024
Spirulina
(Arthrospira
platensis)
is
the
most
famous
species
of
microalgae
and
a
possible
source
important
chemicals
therapeutic
metabolites
with
variety
pharmacological
effects.
This
study
investigated
nutritional
profile
spirulina
powder
its
potential
to
decrease
hyperlipidemia
in
male
Wistar
albino
rats.
The
rats
were
divided
into
five
groups:
G1
(spirulina
300
mg/kg),
G2
600
G3
900
PC
(positive
control;
no
treatment),
NC
[negative
control
+
chow
rodent
diet
(CMD)]
throughout
experimental
period.
Blood
samples
from
analyzed
for
albumin
apoprotein-E,
low-density
lipoprotein
(LDL),
high-density
(HDL),
triglycerides,
cholesterol
levels.
Rat
liver
tissues
examined
histopathologically
observe
morphological
changes
before
after
course
treatment.
Overall
findings
demonstrated
that
comparison
all
other
groups
except
NC,
high
dose
(900
mg/kg)
significantly
decreased
levels
(68.8
±
1.4
mg/dl),
triglyceride
(86.7
2.2
LDL
(20
0.82
mg/dl).
However,
it
also
increased
HDL
(46.8
2.46
mg/dl)
apoprotein-E
(6.13
0.1).
Alanine
transaminase
(ALT)
aspartate
aminotransferase
(AST)
(p
≤
0.05)
reduced
treatment
compared
PC,
NC.
In
conclusion,
an
excellent
mitigate
hyperlipidemia,
promising
prevention
chronic
diseases.
Язык: Английский
Advances in Understanding Diabetic Kidney Disease Progression and the Mechanisms of Acupuncture Intervention
International Journal of General Medicine,
Год журнала:
2024,
Номер
Volume 17, С. 5593 - 5609
Опубликована: Ноя. 1, 2024
Diabetic
kidney
disease
(DKD)
is
a
form
of
damage
resulting
from
diabetes
and
represents
common,
severe
complication
the
disease.
Globally,
DKD
leading
cause
chronic
(CKD).
occurs
in
both
type
1
2
patients,
with
early
clinical
manifestations
including
microalbuminuria
hypertension.
As
condition
progresses,
symptoms
such
as
massive
proteinuria,
hypoalbuminemia,
edema
may
appear.
The
key
to
treating
lies
controlling
blood
glucose
pressure,
reducing
slowing
deterioration
function.
Acupuncture,
traditional
Chinese
medicine
treatment,
has
shown
some
therapeutic
effects
on
through
mechanisms
regulating
glucose,
improving
renal
flow
microcirculation,
antioxidation
anti-inflammation,
modulating
gut
microbiota.
Язык: Английский