Research Square (Research Square),
Год журнала:
2022,
Номер
unknown
Опубликована: Окт. 24, 2022
Abstract
The
prognosis
of
glioma
patients
is
closely
associated
with
the
expression
immune
cells
and
oncoproteins.
Therefore,
protein-related
signatures
were
conducted
to
improve
prediction
overall
survival
(OS)
in
after
surgery.
Differential
oncoproteins
selected
from
Renji
cohort
Cancer
Genome
Atlas
(TCGA)
database.
least
absolute
shrinkage
selection
operator
(LASSO)
regression
model
designed
construct
multiple
oncoprotein
related
OS
two
test
series.
Furthermore,
6-oncoprotein
was
tight
cell
infiltration,
function,
immunotherapy.
In
summary,
marker,
a
favorable
biomarker
for
characteristics
glioma,
could
help
individualized
immunotherapy
glioma.
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(23), С. 15218 - 15218
Опубликована: Дек. 2, 2022
Neurodegenerative
disorders
are
characterized
by
the
progressive
loss
of
central
and/or
peripheral
nervous
system
neurons.
Within
this
context,
neuroinflammation
comes
up
as
one
main
factors
linked
to
neurodegeneration
progression.
In
fact,
has
been
recognized
an
outstanding
factor
for
Alzheimer’s
disease
(AD),
amyotrophic
lateral
sclerosis
(ALS),
Parkinson’s
(PD),
and
multiple
(MS).
Interestingly,
neuroinflammatory
diseases
dramatic
changes
in
epigenetic
profile,
which
might
provide
novel
prognostic
therapeutic
towards
treatment.
Deep
DNA
histone
methylation,
along
with
acetylation
altered
non-coding
RNA
expression,
have
reported
at
onset
inflammatory
diseases.
The
aim
work
is
review
current
knowledge
on
field.
Medicine,
Год журнала:
2025,
Номер
104(5), С. e41393 - e41393
Опубликована: Янв. 31, 2025
Cancer
immune
evasion
is
one
of
the
important
mechanisms
for
cancer
development,
which
essential
to
developing
novel
immunotherapeutic
strategies.
The
SOX
(SRY-related
HMG-box)
family
transcription
factors
plays
a
crucial
role
in
normal
physiology
as
well
variety
human
diseases
especially
cancer.
It
has
been
shown
that
involved
processes.
This
mini-review
aimed
summarize
how
members
induce
by
regulating
antigen
presentation,
shaping
tumor
immunosuppressive
milieu,
and
controlling
regulatory
checkpoint
inhibitors
like
programmed
death
ligand
1.
Thorough
exploration
will
help
uncover
mechanism
evasion,
provide
new
ideas
targets
development
immunotherapy
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(20), С. 12434 - 12434
Опубликована: Окт. 17, 2022
GATA
is
a
transcription
factor
that
exerts
vital
function
in
plant
growth
and
development,
physiological
metabolism,
environmental
responses.
However,
the
gene
family
has
rarely
been
studied
Tartary
buckwheat
since
completion
of
its
genome.
This
study
used
bioinformatics
methods
to
identify
genes
analyze
their
subfamily
classification,
structural
composition,
developmental
evolution,
as
well
discuss
expression
patterns
FtGATA
different
subfamilies.
The
twenty-eight
identified
genome
were
divided
into
four
subfamilies
distributed
on
eight
chromosomes.
One
pair
tandem
repeat
pairs
fragments
found
chromosome
mapping.
Spatiotemporal
indicated
regulatory
roles
tissue
specificity,
fruit
abiotic
stress,
hormonal
creates
theoretical
scientific
foundation
for
further
research
evolutionary
relationship
biological
FtGATA.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(1), С. 851 - 851
Опубликована: Янв. 3, 2023
The
quest
for
eternal
youth
and
immortality
is
as
old
humankind.
Ageing
an
inevitable
physiological
process
accompanied
by
many
functional
declines
that
are
driving
factors
age-related
diseases.
Stem
cell
exhaustion
one
of
the
major
hallmarks
ageing.
SOX
transcription
play
well-known
roles
in
self-renewal
differentiation
both
embryonic
adult
stem
cells.
As
a
consequence
ageing,
repertoire
cells
present
various
organs
steadily
declines,
their
dysfunction/death
could
lead
to
reduced
regenerative
potential
development
Thus,
restoring
function
aged
cells,
inducing
potential,
slowing
down
ageing
critical
improving
health
span
and,
consequently,
lifespan
humans.
Reprograming
factors,
including
family
members,
emerge
crucial
players
rejuvenation.
This
review
focuses
on
diseases,
neurodegenerative
visual
deterioration,
chronic
obstructive
pulmonary
disease,
osteoporosis,
cancers.
A
better
understanding
molecular
mechanisms
this
open
new
avenues
developing
novel
strategies
will
delay
prevent
Communications Biology,
Год журнала:
2024,
Номер
7(1)
Опубликована: Окт. 22, 2024
Abstract
microRNAs
are
crucial
regulators
of
brain
development,
however,
miRNA
regulatory
networks
not
sufficiently
well
characterized.
By
performing
small
RNA-seq
the
mouse
embryonic
cortex
at
E14,
E17,
and
P0
as
in
neural
progenitor
cells
neurons,
here
we
detected
clusters
miRNAs
that
were
co-regulated
distinct
developmental
stages.
such
miR-92a/b
acted
hubs
during
early,
miR-124
miR-137
late
neurogenesis.
Notably,
validated
targets
hub
enriched
for
downregulated
genes
related
to
stem
cell
proliferation,
negative
regulation
neuronal
differentiation
RNA
splicing,
among
others,
suggesting
particularly
important
modulating
transcriptional
programs
factors
guide
switch
differentiation.
As
most
contain
binding
sites
more
than
one
miRNA,
furthermore
constructed
a
co-targeting
network
where
numerous
shared
expected
by
chance.
Using
luciferase
reporter
assays,
demonstrated
simultaneous
pairs
neurodevelopmentally
relevant
exerted
an
enhanced
silencing
effect
compared
single
miRNAs.
Taken
together,
provide
comprehensive
resource
longitudinal
expression
changes
murine
corticogenesis.
Furthermore,
highlight
several
potential
mechanisms
through
which
can
shape
development.
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 18, 2024
Abstract
Background
Approximately
one-third
of
breast
cancer
(BC)
patients
show
poorer
cognitive
function
(CF)
before
receiving
adjuvant
therapy
compared
with
age-matched
healthy
controls.
However,
the
biological
mechanisms
driving
CF
variation
in
context
BC
remain
unclear.
In
this
study,
we
aimed
to
identify
genes
and
pathways
associated
postmenopausal
women
early-stage
hormone
receptor-positive
(HR+)
using
DNA
methylation
(DNAm)
data,
a
dynamic
regulator
gene
activity.
Methods
Epigenome-wide
association
studies
(EWAS)
differentially
methylated
region
analyses
were
performed
for
each
phenotype
(seven
objective
domains
one
subjective
phenotype)
DNAm
data
from
whole
blood
samples
(n=109)
taken
at
time
enrollment.
Post-EWAS
functional
enhance
understanding
CF-related
cytosine-phosphate-guanine
(CpG)
sites.
Results
When
adjusting
age,
verbal
IQ
scores,
global
signature,
cg10331779
near
CTNND2
(p-value=
9.65
×
10
−9
)
cg25906741
MLIP
2.01
−8
processing
speed
CF,
respectively,
while
regions
in/near
SLC6A11
,
PRKG1/CSTF2T
FAM3B
speed,
PI4KB
SGCE/PEG10
mental
flexibility
methylated.
addition,
beta-estradiol
was
identified
as
common
upstream
all
phenotypes,
suggesting
an
essential
role
estrogen
explaining
HR+
patients.
Conclusions
our
EWAS
8
found
two
epigenome-wide
significant
signals,
other
CF.
We
also
three
flexibility.
These
findings
need
replication
larger
cohorts.
