Research Square (Research Square),
Год журнала:
2022,
Номер
unknown
Опубликована: Окт. 24, 2022
Abstract
The
prognosis
of
glioma
patients
is
closely
associated
with
the
expression
immune
cells
and
oncoproteins.
Therefore,
protein-related
signatures
were
conducted
to
improve
prediction
overall
survival
(OS)
in
after
surgery.
Differential
oncoproteins
selected
from
Renji
cohort
Cancer
Genome
Atlas
(TCGA)
database.
least
absolute
shrinkage
selection
operator
(LASSO)
regression
model
designed
construct
multiple
oncoprotein
related
OS
two
test
series.
Furthermore,
6-oncoprotein
was
tight
cell
infiltration,
function,
immunotherapy.
In
summary,
marker,
a
favorable
biomarker
for
characteristics
glioma,
could
help
individualized
immunotherapy
glioma.
Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Янв. 12, 2023
Abstract
The
prognosis
of
glioma
patients
is
closely
associated
with
the
expression
immune
cells
and
oncoproteins.
Therefore,
protein-related
signatures
were
conducted
to
improve
prediction
overall
survival
(OS)
in
after
surgery.
Differential
oncoproteins
selected
from
Renji
cohort
Cancer
Genome
Atlas
(TCGA)
database.
least
absolute
shrinkage
selection
operator
(LASSO)
regression
model
designed
construct
multiple
oncoprotein
related
OS
two
test
series.
Furthermore,
6-oncoprotein
was
tight
cell
infiltration,
function,
immunotherapy.
In
summary,
marker,
a
favorable
biomarker
for
characteristics
glioma,
could
help
individualized
immunotherapy
glioma.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Дек. 16, 2023
Abstract
microRNAs
are
particularly
important
during
brain
development,
however,
the
composition
and
temporal
dynamics
of
miRNA
regulatory
networks
not
sufficiently
characterized.
Here,
we
performed
small
RNA
sequencing
mouse
embryonic
cortical
samples
at
E14,
E17,
P0
as
well
in
neural
progenitor
cells
differentiated
vitro
into
neurons.
Using
co-expression
network
analysis,
detected
clusters
miRNAs
that
were
co-regulated
distinct
developmental
stages.
such
miR-92a/b
acted
hubs
early,
miR-124
miR-137
late
neurogenesis.
Notably,
validated
targets
hub
enriched
for
down-regulated
genes
related
to
stem
cell
proliferation,
negative
regulation
neuronal
differentiation
splicing,
among
others,
suggesting
modulating
transcriptional
programs
crucial
factors
guide
switch
differentiation.
As
most
contain
binding
sites
more
than
one
miRNA,
furthermore
constructed
a
co-targeting
where
numerous
shared
expected
by
chance.
luciferase
reporter
assays,
demonstrated
simultaneous
pairs
neurodevelopmentally
relevant
exerted
an
enhanced
silencing
effect
compared
single
miRNAs.
Taken
together,
our
study
provides
comprehensive
resource
longitudinal
expression
changes
corticogenesis.
Furthermore,
highlight
several
potential
mechanisms
through
which
can
shape
development.
Research Square (Research Square),
Год журнала:
2022,
Номер
unknown
Опубликована: Окт. 24, 2022
Abstract
The
prognosis
of
glioma
patients
is
closely
associated
with
the
expression
immune
cells
and
oncoproteins.
Therefore,
protein-related
signatures
were
conducted
to
improve
prediction
overall
survival
(OS)
in
after
surgery.
Differential
oncoproteins
selected
from
Renji
cohort
Cancer
Genome
Atlas
(TCGA)
database.
least
absolute
shrinkage
selection
operator
(LASSO)
regression
model
designed
construct
multiple
oncoprotein
related
OS
two
test
series.
Furthermore,
6-oncoprotein
was
tight
cell
infiltration,
function,
immunotherapy.
In
summary,
marker,
a
favorable
biomarker
for
characteristics
glioma,
could
help
individualized
immunotherapy
glioma.
