Advances in Animal and Veterinary Sciences,
Год журнала:
2023,
Номер
12(2)
Опубликована: Янв. 1, 2023
egories:
traumatic
and
non-traumatic.The
contusion,
compression,
stretching
of
the
spinal
cord
cause
injury.The
main
causes
non-traumatic
injuries
are
congenital
inflammatory
diseases,
vertebral
spondylosis,
tumour
vascular
ischemia.(Ren
et
al.,
2023).Spinal
injury
was
currently
difficult
to
manage,
there
no
definitive
treatment
for
it,
numerous
studies,
including
experimental
modeling,
were
being
conducted
aid
in
comprehension
anatomical
biological
consequences
repair,
as
well
evaluation
efficacy
risk-to-benefit
ratio
a
proposed
therapy
(Weber-Levine
2022).Comparing
animal
models
Neural Regeneration Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 8, 2024
Abstract
Spinal
cord
injury
is
a
disabling
condition
with
limited
treatment
options.
Multiple
studies
have
provided
evidence
suggesting
that
small
extracellular
vesicles
(SEVs)
secreted
by
bone
marrow
mesenchymal
stem
cells
(MSCs)
help
mediate
the
beneficial
effects
conferred
MSC
transplantation
following
spinal
injury.
Strikingly,
hypoxia-preconditioned
cell-derived
SEVs
(HSEVs)
exhibit
increased
therapeutic
potency.
We
thus
explored
role
of
HSEVs
in
macrophage
immune
regulation
after
rats
and
their
significance
repair.
or
were
isolated
from
supernatants
density
gradient
ultracentrifugation.
HSEV
administration
to
via
tail
vein
injection
reduced
lesion
area
attenuated
inflammation.
regulate
polarization
towards
M2
phenotype
vivo
vitro
.
MicroRNA
sequencing
bioinformatics
analyses
revealed
miR-146a-5p
potent
mediator
targets
interleukin-1
receptor-associated
kinase
1.
Reducing
expression
partially
polarization.
Our
data
suggest
attenuate
inflammation
transporting
miR-146a-5p,
which
alters
This
study
provides
new
insights
into
application
as
tool
for
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Июнь 20, 2024
Abstract
Spinal
cord
injury
(SCI)
often
results
in
motor
and
sensory
deficits,
or
even
paralysis.
Due
to
the
role
of
cascade
reaction,
effect
excessive
reactive
oxygen
species
(ROS)
early
middle
stages
SCI
severely
damage
neurons,
most
antioxidants
cannot
consistently
eliminate
ROS
at
non-toxic
doses,
which
leads
a
huge
compromise
antioxidant
treatment
SCI.
Selenium
nanoparticles
(SeNPs)
have
excellent
scavenging
bioactivity,
but
toxicity
control
problem
limits
therapeutic
window.
Here,
we
propose
synergistic
strategy
SeNPs
encapsulated
by
ZIF-8
(SeNPs@ZIF-8)
obtain
activity.
Three
different
spatial
structures
SeNPs@ZIF-8
were
synthesized
coated
with
ferrostatin-1,
ferroptosis
inhibitor
(FSZ
NPs),
achieve
enhanced
anti-oxidant
anti-ferroptosis
activity
without
toxicity.
FSZ
NPs
promoted
maintenance
mitochondrial
homeostasis,
thereby
regulating
expression
inflammatory
factors
promoting
polarization
macrophages
into
M2
phenotype.
In
addition,
presented
strong
abilities
promote
neuronal
maturation
axon
growth
through
activating
WNT4-dependent
pathways,
while
prevented
glial
scar
formation.
The
current
study
demonstrates
powerful
versatile
bioactive
functions
for
offers
inspiration
other
neural
diseases.
Neural Regeneration Research,
Год журнала:
2024,
Номер
20(4), С. 1042 - 1057
Опубликована: Апрель 3, 2024
Spinal
cord
injuries
impose
a
notably
economic
burden
on
society,
mainly
because
of
the
severe
after-effects
they
cause.
Despite
ongoing
development
various
therapies
for
spinal
injuries,
their
effectiveness
remains
unsatisfactory.
However,
deeper
understanding
metabolism
has
opened
up
new
therapeutic
opportunity
in
form
metabolic
reprogramming.
In
this
review,
we
explore
changes
that
occur
during
consequences,
and
tools
available
Normal
is
characterized
by
independent
cellular
intercellular
coupling.
injury
results
disorders
include
disturbances
glucose
metabolism,
lipid
mitochondrial
dysfunction.
These
lead
to
corresponding
pathological
changes,
including
failure
axonal
regeneration,
accumulation
scarring,
activation
microglia.
To
rescue
at
level,
potential
reprogramming
approaches
have
emerged,
replenishing
substrates,
reconstituting
couplings,
targeting
alter
cell
fate.
The
evidence
suggests
holds
great
promise
as
next-generation
approach
treatment
injury.
further
advance
injury,
future
efforts
should
focus
neurometabolism,
more
advanced
metabolomics
technologies,
design
highly
effective
interventions.
International Journal of Medical Sciences,
Год журнала:
2024,
Номер
21(4), С. 725 - 731
Опубликована: Янв. 1, 2024
Spinal
cord
injury
(SCI)
leads
to
deficits
of
various
normal
functions
and
is
difficult
return
a
state.Histone
non-histone
protein
acetylation
after
SCI
well
documented
regulates
spinal
plasticity,
axonal
growth,
sensory
axon
regeneration.However,
our
understanding
still
limited.In
this
review,
we
summarize
current
research
on
the
role
histone
proteins
in
regulating
neuron
growth
regeneration
SCI.Furthermore,
discuss
inhibitors
activators
targeting
acetylation-related
enzymes,
such
as
α-tubulin
acetyltransferase
1
(αTAT1),
deacetylase
6
(HDAC6),
sirtuin
2
(SIRT2),
provide
promising
opportunities
for
recovery
from
SCI.In
conclusion,
comprehensive
deacetylation
may
contribute
development
treatment.
Spinal Cord,
Год журнала:
2024,
Номер
62(11), С. 609 - 618
Опубликована: Окт. 3, 2024
Abstract
Study
design
Bibliometric
analysis.
Objective
To
analyze
literature
on
inflammatory
expression
following
spinal
cord
injury,
highlighting
development
trends,
current
research
status,
and
potential
emerging
frontiers.
Setting
Not
applicable.
Methods
Articles
were
retrieved
using
terms
related
to
injury
responses
from
the
Web
of
Science
Core
Collection,
covering
January
1,
1980,
May
23,
2024.
Tools
like
CiteSpace
VOSviewer
assessed
landscape,
evaluating
core
authors,
journals,
contributing
countries.
Keyword
co-occurrence
analyses
identified
trends.
Results
A
total
2504
articles
retrieved,
showing
a
consistent
increase
in
publications.
The
Journal
Neurotrauma
had
highest
publication
volume
influence.
most
prolific
author
was
Cuzzocrea
S,
with
Popovich
PG
having
H-index.
China
led
number
publications,
followed
closely
by
United
States,
which
impact
extensive
international
collaboration.
Research
mainly
focused
nerve
function
recovery,
glial
scar
formation,
oxidative
stress.
Future
is
expected
investigate
cellular
autophagy,
vesicular
transport,
signaling
pathways.
Conclusion
growing
interest
inflammation
caused
evident,
focusing
stress,
scar,
neurological
recovery.
directions
include
exploring
autophagy
extracellular
vesicles
for
new
therapies.
Interdisciplinary
clinical
trials
are
essential
validating
treatments.
Biomarker
discovery
crucial
diagnosis
monitoring,
while
understanding
pathways
vital
drug
development.
Global
cooperation
needed
accelerate
application
scientific
findings,
improving
treatment.
CNS Neuroscience & Therapeutics,
Год журнала:
2025,
Номер
31(2)
Опубликована: Фев. 1, 2025
ABSTRACT
Background
Spinal
cord
injury
(SCI)
is
a
complex
central
nervous
system
disorder
characterized
by
multifaceted
pathological
processes,
including
inflammation,
oxidative
stress,
programmed
cell
death,
autophagy,
and
mitochondrial
dysfunction.
Sirtuin
1
(Sirt1),
critical
NAD
+
‐dependent
deacetylase,
has
emerged
as
promising
therapeutic
target
for
SCI
repair
due
to
its
potential
protect
neurons,
regulate
glial
vascular
cells,
optimize
the
microenvironment.
However,
regulatory
roles
of
Sirt1
in
are
challenging,
effects
vary
depending
on
activation
timing,
expression
levels,
types.
Methods
A
systematic
literature
review
was
conducted
using
PubMed,
Scopus,
Web
Science
identify
studies
investigating
SCI.
Relevant
publications
were
analyzed
synthesize
current
evidence
Sirt1's
mechanisms,
effects,
challenges
repair.
Results
exerts
broad
across
diverse
processes
types
post‐SCI.
It
promotes
neuronal
survival
axonal
regeneration,
modulates
astrocytes
microglia
resolve
supports
oligodendrocyte‐mediated
myelination,
enhances
endothelial
function.
Proper
may
mitigate
secondary
injury,
whereas
excessive
or
prolonged
could
impair
inflammatory
resolution
disrupt
cellular
homeostasis.
This
highlights
therapies,
but
include
optimizing
spatiotemporal
addressing
dual
different
Conclusion
Targeting
represents
viable
strategy
repair,
given
regulation
neuroprotection,
immunomodulation,
tissue
remodeling.
translating
these
findings
into
therapies
requires
resolving
issues
such
type‐specific
delivery,
precise
dosage
control.
provides
theoretical
foundation
practical
insights
advancing
Sirt1‐based
treatments
Journal of Translational Medicine,
Год журнала:
2025,
Номер
23(1)
Опубликована: Июнь 2, 2025
Spinal
cord
injury
(SCI)
arises
from
traumatic
damage
to
the
spinal
cord,
resulting
in
varying
degrees
of
sensory,
motor,
and
autonomic
dysfunction.
Mitochondria,
as
primary
energy-producing
organelles
within
cells,
have
garnered
increasing
attention
for
their
critical
role
promoting
axonal
regeneration
following
SCI.
This
review
aims
systematically
examine
alterations
mitochondrial
dynamics
post-SCI
elucidate
influence
on
regeneration.
Furthermore,
evaluates
current
challenges
associated
with
SCI
treatment
proposes
potential
therapeutic
strategies
future
research.
The
comprehensively
addresses
dynamics,
a
focus
key
processes
such
biogenesis,
fusion
fission,
mitophagy,
trafficking,
anchoring.
It
delves
into
molecular
mechanisms
by
which
signaling
pathways
neurons
glial
cells
regulate
these
facilitate
Additionally,
identifies
existing
advocates
targeted
interventions
promising
avenue,
offering
significant
advancing
research
