Heliyon,
Год журнала:
2023,
Номер
9(9), С. e20340 - e20340
Опубликована: Сен. 1, 2023
COVID-19
is
known
to
have
deleterious
effects
on
different
systems
such
as
the
respiratory,
cardiovascular,
central
nervous,
and
gastrointestinal.
However,
conflicting
data
about
possible
implications
for
male
reproductive
health
fertility
been
reported.
In
addition,
long-term
consequences
of
SARS-CoV-2
infection
remain
unclear.
Herein,
we
report
a
case
42-year-old
man
with
no
co-morbidities
normal
baseline
semen
quality,
who
subsequently
suffered
an
asymptomatic
infection.
Shortly
after,
patient
developed
sudden
oligoasthenozoospermia,
even
reaching
azoospermia,
which
gradually
evolved
into
persistent
severe
oligonecrozoospermia,
accompanied
by
inflammation
oxidative
stress.
Remarkably,
latter
occurred
in
absence
urogenital
infections,
hormonal
imbalances,
tissue/organ
obstruction/damage,
medication
or
drug
treatment,
smoking,
exposure
toxins/pollutants,
radiation,
high
temperature.
This
constitutes
valuable
clinical
evidence
that
adds
current
knowledge
field
highlights
need
further
longer
follow-up
studies
better
understand
putative
fertility.
The Egyptian Journal of Medical Microbiology,
Год журнала:
2024,
Номер
33(2), С. 0 - 0
Опубликована: Фев. 10, 2024
Background;
Antimicrobial
resistance
(AMR)
among
bacteria
causing
male
genitourinary
infections
has
the
potential
to
affect
fertility.
The
objective
of
this
work
is
determine
differences
in
AMR
patterns
bacteriospermia
infertile
men
before
and
during
COVID-19
pandemic.
Methods:
This
an
observational
comparative
study
which
non-duplicate
semen
cultures
from
infertility
cases
presented.
are
defined
as
per
protocol
Ministry
Health
Population
(MOHP)
Egypt.
susceptibility
reporting
was
performed
agreement
with
Clinical
Laboratory
Standard
Institute
(CLSI,
2020).
Results;
A
total
176
samples
were
processed
period.
108
(61.4%)
68
(38.6%)
pre-
era.
commonest
pathogens
isolated
S.
Aureus
[60
(55.6%)
40
(58.8%)],
epidermidis
[12
(11.1%)
8
(11.8%)]
for
N.gonorrhoea
[11
(10.2%)
6
(8.8%)]
pre-and
COVID
-19
period
respectively.
Significant
antimicrobial
observed
Nalidixic
acid
(P
<0.001),
Erythromycin
<0.001)
Clarithromycin
<0.001).
Similar
significant
Cefepime'
Meropenem
antibiotics.
Further,
22
(20.4%)
isolates
multi-drug-resistant
Conclusion;
Pathogens
presented
levels
Further
research
control
groups
needed
better
understand
effects
on
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Фев. 26, 2024
Background
The
inactivated
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
vaccine
has
made
significant
contributions
to
fighting
the
epidemic
in
past
three
years.
However,
rapid
development
and
application
raised
concerns
about
its
safety
reproductive
health,
especially
after
several
studies
had
observed
a
decrease
semen
parameters
following
two
doses
of
mRNA
SARS-CoV-2
vaccination.
Thus,
it
is
necessary
comprehensively
evaluate
effect
on
male
fertility.
Methods
A
retrospective
cohort
study
was
conducted
Center
for
Reproductive
Medicine
Affiliated
Hospital
Jining
Medical
University
between
July
2021
March
2023.
total
409
men
with
different
vaccination
status
no
history
infection
were
included
this
study.
Their
sex
hormone
levels
evaluated
compared
separately.
Results
FSH
PRL
one-dose
vaccinated
group
higher
than
other
groups,
while
there
changes
control
groups.
Most
such
as
volume,
sperm
concentration,
count,
progressive
motility
normal
forms
similar
before
any
single
dose
or
combination
(all
P
>
0.05).
Nevertheless,
significantly
decreased
receiving
1
+
(46.90
±
2.40%
vs
.
58.62
2.51%;
=
0.001).
Fortunately,
parameter
still
within
range.
Conclusion
Our
demonstrated
that
combined
not
detrimental
This
information
could
reassure
who
want
conceive
be
incorporated
into
future
fertility
recommendations.
Medicine,
Год журнала:
2024,
Номер
103(10), С. e37346 - e37346
Опубликована: Март 8, 2024
Since
December
2019,
COVID-19
has
triggered
a
global
pandemic.
The
association
of
with
the
long-term
reproductive
situation
women
and
males
is
not
clear.
Thus,
our
aim
was
to
assess
causal
between
infertility
using
Mendelian
randomization
(MR)
analysis
based
on
OpenGWAS
database.
Two-sample
MR
conducted
one
genome-wide
study
(GWAS)
in
individuals
European
ancestry.
summary
data
genetic
variation
come
from
GWAS
populations.
We
applied
several
methods,
including
Egger,
weighted
median,
inverse
variance
weighted,
simple
mode,
test
relationships.
After
observing
statistical
results
MR,
we
sensitivity
robustness.
gene
prediction,
it
found
that
there
no
clear
relationship
male
[OR
0.4702
(95%
CI,
0.1569-1.4093),
P
=
.178].
Moreover,
associated
female
0.9981
0.763-1.544),
.646].
Sensitivity
showed
were
robust
[level
pleiotropy,
male:
(MR-Egger,
intercept
0.1967434;
se
0.1186876;
.2392406);
female:
-0.05902506;
0.05362049;
.3211367)].
To
further
validate
impact
infertility,
added
covariate
(sex
hormone
binding
levels,
abortion)
analysis,
which
multivariate
analysis.
According
univariate
analyses,
evidence
does
support
risk
factor
for
population.
This
information
can
provide
doctors
centers
when
managing
patients.
Deleted Journal,
Год журнала:
2023,
Номер
1(1), С. 01 - 12
Опубликована: Сен. 27, 2023
Introdução:
Os
casos
de
infertilidade
vêm
aumentando
exponencialmente
nos
últimos
anos.
Estudos
recentes
sugerem
que
a
infecção
pelo
COVID-19
pode
afetar
tanto
na
formação
gametas
viáveis,
quanto
no
eixo
hipotálamo-hipófise-gonadal
homens
e
mulheres.
Objetivo:
Identificar
relação
entre
prévia
vírus
da
COVID-19.
Métodos:
Estudo
revisão
integrativa,
conduzido
acordo
com
as
seguintes
etapas:
elaboração
questão
pesquisa,
busca
literatura,
categorização
dos
estudos,
avaliação
crítica,
interpretação
resultados
apresentação
integrativa.
Foram
utilizadas
bases
dados
Pubmed/Medline,
Cochrane
Library
BVS
(Biblioteca
virtual
em
saúde).
utilizados
os
termos,
seus
sinônimos
combinações:
“infertility”,
“post
covid-19”.
O
operador
booleano
AND
foi
utilizado.
Resultados:
encontradas
94
referências
durante
eletrônica,
sendo
14
(quatorze)
elegíveis
incluídos.
Todos
estudos
incluídos
demonstraram
haver
ligação
Sars-Cov-2
acometimentos
sistema
reprodutivo
nas
taxas
fertilidade
humana.
Em
geral,
população
foram
mulheres
idade
reprodutiva,
exposição
à
por
mecanismos
levaram
esse
resultado
se
deram
efeito
direto
estruturas
reprodutivas;
impacto
hipotálamo-hipófise-gonadal;
resposta
inflamatória
mediada
citocinas
decorrentes
própria
infecção.
Conclusão:
Evidências
iniciais
apontam
sequelas
saúde
reprodutiva
humana
podem
possuir
caráter
longo
prazo
alguns
pacientes
infectados
É
preciso
continue
investigando
o
assunto,
para
possa
prever
impactos
precisos
humana,
pandemia
Women’s Healthcare A Clinical Journal for NPs,
Год журнала:
2023,
Номер
11(1), С. 27 - 32
Опубликована: Янв. 30, 2023
Providing
care
for
men
and
their
fertility
concerns
is
within
the
WHNP’s
scope
of
practice,
with
ability
to
recognize
male
factor
infertility
make
an
initial
investigation
leading
prompt
referral
treatment.
COVID-19
exerts
deleterious
effects
on
the
respiratory,
cardiovascular,
gastrointestinal,
and
central
nervous
systems;
however,
there
are
still
controversial
data
regarding
putative
consequences
male
reproductive
tract
fertility.
Furthermore,
long-term
of
SARS-CoV-2
infection
uncertain.
Herein,
we
report
a
case
42-year-old
man
with
no
known
co-morbidities
normal
baseline
semen
quality,
who
subsequently
suffered
an
asymptomatic
infection.
Shortly
after,
patient
developed
sudden
oligoasthenozoospermia,
even
reaching
azoospermia,
which
gradually
evolved
into
persistent
severe
oligonecrozoospermia,
accompanied
inflammation
oxidative
stress.
Remarkably,
latter
occurred
in
absence
urogenital
infections,
hormonal
imbalances,
tissue/organ
obstruction/damage,
medication
or
drug
treatment,
smoking,
exposure
to
toxins/pollutants.
This
constitutes
valuable
clinical
evidence
that
adds
current
knowledge
field
highlights
need
for
further
longer
follow-up
studies
better
understand
Heliyon,
Год журнала:
2023,
Номер
9(9), С. e20340 - e20340
Опубликована: Сен. 1, 2023
COVID-19
is
known
to
have
deleterious
effects
on
different
systems
such
as
the
respiratory,
cardiovascular,
central
nervous,
and
gastrointestinal.
However,
conflicting
data
about
possible
implications
for
male
reproductive
health
fertility
been
reported.
In
addition,
long-term
consequences
of
SARS-CoV-2
infection
remain
unclear.
Herein,
we
report
a
case
42-year-old
man
with
no
co-morbidities
normal
baseline
semen
quality,
who
subsequently
suffered
an
asymptomatic
infection.
Shortly
after,
patient
developed
sudden
oligoasthenozoospermia,
even
reaching
azoospermia,
which
gradually
evolved
into
persistent
severe
oligonecrozoospermia,
accompanied
by
inflammation
oxidative
stress.
Remarkably,
latter
occurred
in
absence
urogenital
infections,
hormonal
imbalances,
tissue/organ
obstruction/damage,
medication
or
drug
treatment,
smoking,
exposure
toxins/pollutants,
radiation,
high
temperature.
This
constitutes
valuable
clinical
evidence
that
adds
current
knowledge
field
highlights
need
further
longer
follow-up
studies
better
understand
putative
fertility.
