Side effects of drugs annual, Год журнала: 2023, Номер unknown, С. 303 - 335
Опубликована: Янв. 1, 2023
Язык: Английский
Arteriosclerosis Thrombosis and Vascular Biology, Год журнала: 2023, Номер 43(10)
Опубликована: Авг. 10, 2023
Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare syndrome characterized by platelet anti-PF4 (platelet-activating antiplatelet factor 4)-related thrombosis. Platelet-neutrophil interaction has been suggested to play role, but the underlying mechanism not fully elucidated.The study included 10 patients with VITT after ChAdOx1 (chimpanzee adenovirus Oxford 1) nCoV-19 (Oxford-AstraZeneca) vaccine administration, ischemic stroke (IS), acute deep vein thrombosis, and control subjects in whom blood levels of neutrophil extracellular traps (NETs), soluble TF (tissue factor), thrombin generation were examined. Furthermore, we performed vitro studies comparing effect serum from controls on NETs formation. Finally, immunohistochemistry was cerebral thrombi retrieved 3 IS.Compared IS, controls, had significantly higher values CitH3 (citrullinated histone H3), TF, D-dimer, prothrombin fragment 1+2 (P<0.0001). Blood correlated (Spearman rank correlation coefficient=0.7295; P=0.0206) coefficient=0.6809; P<0.0350) VITT. mixture added plasma resulted formation, generation, platelet-dependent thrombus growth under laminar flow compared IS thrombosis plasma; these effects blunted PAD4 (protein arginine deiminase 4) cathepsin G inhibitors, anti-FcγRIIa (Fc receptor for IgG class IIa), high doses heparin. Immunohistochemistry analysis showed more marked expression along diffuse infiltration formation as well IS.Patients display enhanced thrombogenesis PAD4-mediated via G-mediated platelet/neutrophil interaction.
Язык: Английский
Процитировано
11
International Journal of Innovative Science and Research Technology (IJISRT), Год журнала: 2024, Номер unknown, С. 2585 - 2591
Опубликована: Июнь 11, 2024
The onset of Coronavirus disease 2019 (COVID-19) in late presented a severe worldwide health crisis with widespread morbidity and mortality. Various vaccine platforms have been rapidly developed approved for broad use swift urgent response to prevent the transmission Severe Acute Respiratory Syndrome 2 (SARS-CoV-2) infection. However, these vaccines differ significantly terms safety. Heterologous prime-boost vaccination enhances safety compared homologous vaccination, although it could lead higher cumulative number transient adverse events reported at each visit. Therefore, additional strategies are necessary improve SARS- CoV-2 Anecdotal options suggest that co-administration can reduce effects consequently, avert need frequent booster doses. This study reports immunization outcomes against SARS-CoV-2 virus by assessing profiles different co-administered BALB/c mice. Vaccine combinations comprising mRNA/adenovirus26-vector, mRNA/inactivated, adenovirus26-vector/inactivated, mRNA/adenovirus26-vector/inactivated were prepared optimized doses, their activities upon evaluated comparison individual mRNA, adenovirus26-vectored inactivated vaccines. Twenty-eight days post-immunization, various treatments through hematological biochemical examination. Importantly, regimens proved safe well-tolerated mice, as evidenced normal values.
Язык: Английский
Процитировано
1
Radiology Case Reports, Год журнала: 2024, Номер 19(9), С. 4087 - 4090
Опубликована: Июль 13, 2024
COVID-19 vaccines, a cornerstone of the fight against disease have generally proven to be safe with most commonly reported side effects being mild and self-limiting. Uncommon severe adverse like thromboembolism been during postmarketing surveillance. Viral-based vector vaccines implicated in these reports. Our report however portrays case 26-year-old female who developed extensive pulmonary embolism following administration Pfizer- BNT162b2 mRNA vaccine. The patient did not any risk factors for thromboembolism. She was admitted, put on enoxaparin, given Altaplase thrombolytic therapy. Her condition improved she discharged Apixaban. Thrombophilia screen performed 6-month follow-up negative resolution thrombosis, Apixaban stopped. highlights importance continued surveillance uncommon need prompt diagnosis management such effects.
Язык: Английский
Процитировано
1
Infectious Diseases and Therapy, Год журнала: 2022, Номер 12(2), С. 303 - 315
Опубликована: Дек. 15, 2022
Primary immune thrombocytopenia (ITP) is an acquired autoimmune disease with highly variable presentation, characteristics, and clinical course. Thrombocytopenia a common complication of many viral infections, including SARS-CoV-2. In addition, both de novo ITP exacerbation after vaccination against SARS-CoV-2 have been reported. Patients infected develop prothrombotic coagulopathy called COVID-19-associated (CAC). hematological disorders secondary to infection, mainly hemolytic anemia (AIHA), described. Furthermore, infection has associated processes, ITP. fact, there evidence high relapse rate in patients preexisting COVID-19. As for SARS-CoV-2, adverse events (HAE) are practically anecdotal. The most HAE thrombocytopenia-associated thrombosis syndrome (TTS) linked vectored virus vaccines. Other HAEs very rare, but should be considered previous complement activation or autoimmunity. who vaccinated the main bleeding that may result. this occurs 12% patients, splenectomized refractory more than five lines treatment platelet counts below 50 × 109/L being vulnerable. We conclude that, general, no greater risk severe general population. changes advised stable ITP, use immunosuppressants discouraged unless other therapeutic option, not contraindicated
Язык: Английский
Процитировано
5
Archives of Medical Research, Год журнала: 2022, Номер 53(4), С. 341 - 351
Опубликована: Май 7, 2022
Язык: Английский
Процитировано
3
Cureus, Год журнала: 2024, Номер unknown
Опубликована: Июнь 16, 2024
Omental infarction is an uncommon cause of abdominal pain. The condition often misdiagnosed due to its clinical similarity more common pathologies like appendicitis and cholecystitis. This report presents the case a 57-year-old female with one-week history left-sided pain, initially aggravated by eating defecation. patient, long-term smoker complex medical that includes deep vein thrombosis pulmonary embolism, was hemodynamically stable on presentation. A CT scan revealed nodular infiltration consistent omental infarct. Conservative management pursued, resulting in symptom resolution third day hospitalization. underscores diagnostic challenges associated infarction, particularly differentiation from other causes acute It highlights importance considering rare etiologies patients atypical presentations emphasizes role imaging, scans, accurate diagnosis. patient's successful conservative aligns current recommendations, which advocate for non-surgical treatment most cases. approach avoids unnecessary surgical interventions ensures favorable prognosis low complication rates prompt appropriate management.
Язык: Английский
Процитировано
0
American Journal of Clinical and Experimental Medicine, Год журнала: 2023, Номер unknown
Опубликована: Янв. 13, 2023
Background: A COVID 19 vaccine is a intended to provide acquired immunity against severe acute respiratory syndrome corona virus 2. Ad26.COV2.S (Johnson & Johnson) adenovirus vector-based that targets the spike protein of SARS-CoV-2 virus, when it enters body stimulates immune response. Materials and methods: This was cross sectional study, health facility base, Conducted in Vaccine centre at Omer ben Alkhatab, Khartoum, Sudan during period July August, 2022 estimate changes coagulation parameters among Sudanese vaccinated with Johnson vaccine. Sixty samples were collected from Participants took first dose vaccine; thirty before vaccination, after vaccination. The performing by different methods. Results: means vaccination were; APTT (36.2 ±3), PT (15.8±2.4), INR (1.2 ±0.2), platelets (285.9 ±7.2), fibrinogen (243.4 ±4.6) D-dimer (0.17±0.03). for APTT, PT, INR, count, (35.2 ±2.9), (13.9±2.1), (1.21±0.3), (272.8±57.9), (284.2 ±53.3) (0.37±0.8) respectively. When compared between results per post revealed that; there significant decrease time PTT (p value ≤0.05), differences count ≥0.05), increase D- dimer level ≤0.05). While mean age, genders, symptoms insignificant except D – had age ≤0.05). Conclusion: In conclusion this study activated partial thromboplastin (APTT), Prothrombin (PT), individuals Vaccine.
Язык: Английский
Процитировано
1
Hematology Transfusion and Cell Therapy, Год журнала: 2022, Номер 45(4), С. 456 - 460
Опубликована: Окт. 18, 2022
Approximately 55.52% of the Indian population had been fully vaccinated by Jan. 2022, since its first roll out on January 16, 2021. A few concerns were raised concerning Covishield vaccination related to thrombotic thrombocytopenia. Apheresis-derived platelet concentrates are frequently required in a plethora clinical situations and post-vaccination decrement counts might lead increased deferral platelet-pheresis donors.The aim study was discover effect rates plateletpheresis donors.Blood samples collected from potential donors for completion standard questionnaire complete blood count. The data tabulated MS Excel spreadsheet biostatistical analysis performed with SPSS v23. p-value < 0.05 taken as significant. We compared this age- sex-matched controls.The mean age cases controls 29.69 ± 8.57 30.15 7.11, respectively. There significant difference (188496.35 72065.66/cumm) (269524.50 53981.60/cumm). Furthermore, who received one dose higher 248676.47 80075.24/cumm than those both doses vaccine (179970.83 66773.73/cumm) . between two groups remarkable (34.7% vs. 0.9%, 0.001).Vaccination certainly due low counts. Average individuals, however, platelets returned normal days progressed.
Язык: Английский
Процитировано
1
Medical Science, Год журнала: 2022, Номер 26(126), С. 1 - 7
Опубликована: Авг. 27, 2022
Background: A number of vaccines were introduced to fight the COVID-19 pandemic; however, questions have been raised about their safety.Aims: The objective this study was assess adverse effects that students at Mutah University who received various reported experiencing.Methods: cross-sectional online survey employing a well-designed questionnaire undertaken look for any side university might experienced after receiving single or double dose several vaccines.Results: sample consisted 416 students, whom 61 percent women and around 38 had COVID-19.In addition, 70.9 research participants Pfizer vaccine, 28.1 got Sinopharm just 0.7 0. 2 percent, respectively, selected AstraZeneca vaccine Moderna vaccine.Localized discomfort following injection (reported by 75%of participants), fatigue 56.6%), headache 52.4%), myalgia 49%), fever 43%), chills 37.3%), arthralgia (37.3 percent) most common effects.Conclusion: Majority short -term are mild.Nonetheless, additional studies required evaluating long-term effects.
Язык: Английский
Процитировано
1
Vaccine, Год журнала: 2023, Номер 41(22), С. 3399 - 3402
Опубликована: Апрель 28, 2023
Premature unblinding of individual participants is rarely reported in publications, but such can disrupt vaccine trials by causing worry and drop-out other or "pseudo unblinding," which investigators over-interpret certain symptoms as being related to receiving an investigational product. This review summarizes appropriate reasons for trials. Regulatory guidance could be improved distinguishing from drug trials, with the recognition that studies needed management adverse events following immunization.
Язык: Английский
Процитировано
0