Efficacy and Predictive Factors of Intravesical Botulinum Toxin A Injection for Treating Neurogenic Detrusor Overactivity in Children: A Single-Center Retrospective Study DOI Creative Commons
Chun‐Kai Hsu, Han‐Yu Lin, Stephen Shei‐Dei Yang

и другие.

Toxins, Год журнала: 2025, Номер 17(4), С. 202 - 202

Опубликована: Апрель 17, 2025

Neurogenic detrusor overactivity (NDO) is a complex condition associated with overactivity, reduced bladder compliance, and high intravesical pressures, potentially leading to urinary tract infections (UTIs) renal impairment. This retrospective study evaluated the safety potential efficacy of botulinum toxin A (BoNT/A) injections in children NDO at single institution. Eighteen pediatric patients (median age: 8.1 years) were followed for median 6.3 years. At follow-up, 77.8% achieved global response assessment (GRA) score ≥2. statistically significant improvement was found cystometric capacity (p = 0.041), but it did not remain after Bonferroni correction, while other urodynamic trends significant. Adverse events infrequent, only 11.8% experiencing mild febrile UTIs. While some poorer baseline conditions reported greater subjective improvement, no predictors success identified. Overall, BoNT/A injection appears be safe effective option managing NDO, though larger prospective studies are needed confirm these findings.

Язык: Английский

Sexual Dysfunction as it Intersects with Neurogenic Lower Urinary Tract Dysfunction in Women DOI Creative Commons
Akash Sharma,

Tracy Cheung,

Nitya Abraham

и другие.

Current Bladder Dysfunction Reports, Год журнала: 2025, Номер 20(1)

Опубликована: Апрель 2, 2025

Язык: Английский

Процитировано

0
Efficacy and Predictive Factors of Intravesical Botulinum Toxin A Injection for Treating Neurogenic Detrusor Overactivity in Children: A Single-Center Retrospective Study DOI Creative Commons
Chun‐Kai Hsu, Han‐Yu Lin, Stephen Shei‐Dei Yang

и другие.

Toxins, Год журнала: 2025, Номер 17(4), С. 202 - 202

Опубликована: Апрель 17, 2025

Neurogenic detrusor overactivity (NDO) is a complex condition associated with overactivity, reduced bladder compliance, and high intravesical pressures, potentially leading to urinary tract infections (UTIs) renal impairment. This retrospective study evaluated the safety potential efficacy of botulinum toxin A (BoNT/A) injections in children NDO at single institution. Eighteen pediatric patients (median age: 8.1 years) were followed for median 6.3 years. At follow-up, 77.8% achieved global response assessment (GRA) score ≥2. statistically significant improvement was found cystometric capacity (p = 0.041), but it did not remain after Bonferroni correction, while other urodynamic trends significant. Adverse events infrequent, only 11.8% experiencing mild febrile UTIs. While some poorer baseline conditions reported greater subjective improvement, no predictors success identified. Overall, BoNT/A injection appears be safe effective option managing NDO, though larger prospective studies are needed confirm these findings.

Язык: Английский

Процитировано

0