The distal resection of the rectal pouch in laparoscopic-assisted anorectoplasty for males with anorectal malformation: 153 cases’ experience in a single center DOI Creative Commons

Shiru Ye,

Yan Zhou, Zheng Chen

и другие.

Research Square (Research Square), Год журнала: 2023, Номер unknown

Опубликована: Июль 14, 2023

Abstract Purpose This study aimed to evaluate the factors associated with constipation and efficacy of distal resection length (DRL) not less than 3cm in males anorectal malformation (ARM). Methods Demographic, anomalies, clinical features, bowel function ARM rectourethral/rectovesical fistula (RUF/RVF) were evaluated. The Krickenbeck scores used assess function. Univariate multivariate analysis identify constipation. was evaluated between groups categorized by DRL after 1:1 propensity score matching (PSM). Result A total 153 a median follow-up period 6 years, 54(35.2%) suffered from Multivariate revealed that (OR = 0.68, P 0.007) is only independent protective factor potty training. After PSM, 35 patients included each DRL≥3.0cm DRL＜3cm, well-balanced. No significant differences noted postoperative complications (11.4% vs. 25.7% 0.218) constant soiling (17.1% 31.4%, 0.718). However, incidence group significantly lower DRL＜3cm group(37.1% 71.4%, 0.028). Conclusion longer for constipation, suggesting excessive preservation rectal pouch cause And rate ≥3cm without increment which may be fibrosis last pouch. Thus, recommended resect ARM.

Язык: Английский

Food additives impair gut microbiota from healthy individuals and IBD patients in a colonic in vitro fermentation model DOI
Irma Gonza,

Elizabeth Goya-Jorge,

Caroline Douny

и другие.

Food Research International, Год журнала: 2024, Номер 182, С. 114157 - 114157

Опубликована: Фев. 28, 2024

Язык: Английский

Процитировано

12
Role of gut microbiota in Crohn’s disease pathogenesis: Insights from fecal microbiota transplantation in mouse model DOI
Qiang Wu, Lianwen Yuan,

Lichao Yang

и другие.

World Journal of Gastroenterology, Год журнала: 2024, Номер 30(31), С. 3689 - 3704

Опубликована: Авг. 13, 2024

Inflammatory bowel disease, particularly Crohn's disease (CD), has been associated with alterations in mesenteric adipose tissue (MAT) and the phenomenon termed "creeping fat". Histopathological evaluations showed that MAT intestinal tissues were significantly altered patients CD, these characterized by inflammation fibrosis.

Язык: Английский

Процитировано

11
Mechanisms and therapeutic research progress in intestinal fibrosis DOI Creative Commons

Yanjiang Liu,

Tao Zhang, Kejian Pan

и другие.

Frontiers in Medicine, Год журнала: 2024, Номер 11

Опубликована: Июнь 14, 2024

Intestinal fibrosis is a common complication of chronic intestinal diseases with the characteristics fibroblast proliferation and extracellular matrix deposition after inflammation, leading to lumen narrowing, structural functional damage intestines, life inconvenience for patients. However, anti-inflammatory drugs are currently generally not effective in overcoming making surgery main treatment method. The development slow process its onset may be result combined action inflammatory cells, local cytokines, stromal cells. aim this study elucidate pathogenesis [e.g., (ECM), cytokines chemokines, epithelial-mesenchymal transition (EMT), differentiation myofibroblast microbiota] underlying explore therapeutic advances (such as regulating ECM, EMT, targeting TGF- β ) based on order gain new insights into prevention fibrosis.

Язык: Английский

Процитировано

6
Role of the epithelial barrier in intestinal fibrosis associated with inflammatory bowel disease: relevance of the epithelial-to mesenchymal transition DOI Creative Commons
Dulce C. Macias-Ceja,

M. Teresa Mendoza-Ballesteros,

María Ortega-Albiach

и другие.

Frontiers in Cell and Developmental Biology, Год журнала: 2023, Номер 11

Опубликована: Сен. 26, 2023

In inflammatory bowel disease (IBD), chronic inflammation in the gastrointestinal tract can lead to tissue damage and remodelling, which ultimately result fibrosis. Prolonged injury trigger activation of fibroblasts extracellular matrix (ECM) components. As fibrosis progresses, becomes increasingly stiff less functional, complications such as intestinal strictures, obstructive symptoms, eventually, organ dysfunction. Epithelial cells play a key role fibrosis, they secrete cytokines growth factors that promote fibroblast ECM deposition. Additionally, epithelial undergo process called epithelial-mesenchymal transition, acquire more mesenchymal-like phenotype contribute directly Overall, interactions between cells, immune critical development progression IBD. Understanding these complex may provide new targets for therapeutic interventions prevent or treat this review, we have collected discussed recent literature highlighting contribution pathogenesis fibrotic IBD, including evidence EMT, epigenetic control potential influence microbiome possible strategies target EMT. Finally discuss pro-fibrotic epithelial-immune epithelial-fibroblasts cells.

Язык: Английский

Процитировано

13
Disease clearance in ulcerative colitis: A new therapeutic target for the future DOI Creative Commons
Syed Adeel Hassan,

Neeraj Kapur,

Fahad Sheikh

и другие.

World Journal of Gastroenterology, Год журнала: 2024, Номер 30(13), С. 1801 - 1809

Опубликована: Апрель 2, 2024

Advancements in murine modeling systems for ulcerative colitis have diversified our understanding of the pathophysiological factors involved disease onset and progression. This has fueled identification molecular targets, resulting a rapidly expanding therapeutic armamentarium. Subsequently, management strategies evolved from symptomatic resolution to well-defined objective endpoints, including clinical remission, endoscopic remission mucosal healing. While incorporation these assessment modalities permitted targeted intervention context natural history prevention complications, studies consistently depicted discrepancies associated with ascertaining status through measures. Current recommendations lack consideration histological The simultaneous achievement clinical, endoscopic, histologic not been fully investigated. laid groundwork novel outcome termed clearance (DC). article summarizes concept DC its current evidence.

Язык: Английский

Процитировано

5
Pathways Affected by Falcarinol-Type Polyacetylenes and Implications for Their Anti-Inflammatory Function and Potential in Cancer Chemoprevention DOI Creative Commons

Ruyuf Alfurayhi,

Lei Huang, Kirsten Brandt

и другие.

Foods, Год журнала: 2023, Номер 12(6), С. 1192 - 1192

Опубликована: Март 11, 2023

Polyacetylene phytochemicals are emerging as potentially responsible for the chemoprotective effects of consuming apiaceous vegetables. There is some evidence suggesting that polyacetylenes (PAs) impact carcinogenesis by influencing a wide variety signalling pathways, which important in regulating inflammation, apoptosis, cell cycle regulation, etc. Studies have shown correlation between human dietary intake PA-rich vegetables with reduced risk inflammation and cancer. PA supplementation can influence growth, gene expression immunological responses, has been to reduce tumour number rat mouse models. Cancer chemoprevention PAs involves several mechanisms, including on inflammatory cytokines, NF-κB pathway, antioxidant response elements, unfolded protein (UPR) growth factor signalling, progression apoptosis. This review summarises published research falcarinol-type compounds their mechanisms action regarding cancer also identifies gaps our current understanding health benefits these PAs.

Язык: Английский

Процитировано

10
Epigenetic Regulation of EMP/EMT-Dependent Fibrosis DOI Open Access
Margherita Sisto, Sabrina Lisi

Опубликована: Янв. 3, 2024

Fibrosis represents a process characterized by excessive deposition of extracellular matrix (ECM) proteins. It often the evolution pathological conditions, causes organ failure, and can, in extreme cases, compromises functionality organs to point causing death. In recent years, considerable efforts have been made understand molecular mechanisms underlying fibrotic identify possible therapeutic strategies. Great interest has aroused discovery association between epithelial mesenchymal plasticity (EMP), particular transition (EMT), fibrogenesis, which led identification complex closely interconnected with each other, could explain EMT-dependent fibrosis. However, result remains unsatisfactory from view. advances epigenetics, is based on chromatin remodeling through various histone modifications or intervention non-coding RNAs (ncRNAs), provided more information process, this represent promising path forward for innovative strategies review, we summarize current research epigenetic involved fibrosis, focus regulation EMP/EMT-dependent

Язык: Английский

Процитировано

4
Characterization of patient-derived intestinal organoids for modelling fibrosis in Inflammatory Bowel Disease DOI Creative Commons
Ilaria Laudadio, Claudia Carissimi,

Noemi Scafa

и другие.

Inflammation Research, Год журнала: 2024, Номер 73(8), С. 1359 - 1370

Опубликована: Июнь 6, 2024

Abstract Background and aims Intestinal fibrosis is a common complication of Inflammatory Bowel Disease (IBD), namely Crohn's disease (CD) ulcerative colitis (UC), but the precise mechanism by which it occurs incompletely understood hampering development effective therapeutic strategies. Here, we aimed at inducing characterizing an inflammation-mediated in patient-derived organoids (PDOs) issued from crypts isolated colonic mucosal biopsies IBD pediatric patients age matched-control subjects (CTRLs). Methods Inflammatory-driven was induced exposing CTRL-, CD- UC-PDOs to pro-inflammatory cytokine TNF-α for one day, followed co-treatment with TGF-β1 three days. Fibrotic response proven analyzing inflammatory fibrotic markers RT-qPCR immunofluorescence. Transcriptomic changes were assessed RNA-sequencing. Results Co-treatment caused CTRL- IBD-PDOs morphological towards mesenchymal-like phenotype up-regulation inflammatory, mesenchymal, markers. profiling highlighted that all intestinal PDOs, regardless disease, co-exposure regulated EMT genes specifically increased involved positive regulation cell migration. Finally, demonstrated CD-PDOs display specific compared both UC-PDOs, mainly characterized upregulation nuclear factors controlling transcription. Conclusions This study demonstrates PDOs may develop inflammatory-derived thus representing promising tool fibrogenesis IBD. show expression genes. In particular, gene signature UC CTRL-PDOs.

Язык: Английский

Процитировано

4
Prominence of Microbiota to Predict Fibrous Stenosis in Crohn’s Disease DOI Creative Commons
Xue Yang, Yan Pan, Cai-Ping Gao

и другие.

Journal of Inflammation Research, Год журнала: 2025, Номер Volume 18, С. 1413 - 1423

Опубликована: Фев. 1, 2025

Purpose: Intestinal fibrous stenosis due to Crohn's disease (CD) is highly prevalent. Although several clinical risk factors for have been identified, such as perianal fistulizing disease, small bowel location, and deep mucosal ulceration, predicting remains challenging. The intestinal microbiota plays a crucial role in the development progression of CD. However, its poorly understood. Leveraging single-center cross-sectional study, we aimed investigate fecal CD-associated stenosis. Methods: Using metagenomic analysis, examined differences between CD patients with those without We identified specific assessed their predictive accuracy Additionally, explored functional two groups. Results: : Our investigation samples revealed no significant gut structure taxonomically, found 70 taxa significantly different abundance (p < 0.05) Furthermore, LEfSe analysis indicated that g_Bacteroides g_Enterocloster could predict while p_Actinobacteria, c_Actinomycetia, c_Bacilli, o_Lactobacillales, f_Streptococcaceae g_Streptococcus Functional differential enrichment five metabolic pathways at KEGG pathway level stenosis, including sphingolipid metabolism, lipoic acid biosynthesis neomycin, kanamycin gentamicin. In eggNOG database, observed four categories groups, encompassing cellular process, signaling, metabolism. Conclusion: Fecal impacted there were alpha beta diversities, was associated changes composition function, suggesting potential Keywords: microbiota,

Язык: Английский

Процитировано

0
Fibrosierende Erkrankungen im Gastrointestinaltrakt DOI
Elke Roeb

Deleted Journal, Год журнала: 2025, Номер unknown

Опубликована: Март 3, 2025

Chronische Leberschäden, wie die mit metabolischer Dysfunktion assoziierte steatotische Lebererkrankung (MASLD), virale Hepatitis B oder C, cholestatische Hepatitiden (PBC, PSC), toxische Schädigungen (Alkohol) genetische Alterationen (Hämochromatose, Morbus Wilson usw.) verursachen in der Regel eine chronische Entzündungsreaktion Leberzellen Gallengangepithelien. Diese kann über längere Zeit zu einer Vernarbung Leber, sog. Fibrose führen. Die Leberfibrose ist dabei größtenteils unabhängig vom schädigenden Agens, obwohl das Muster anfänglichen (periportal, perizentral sinusoidal) durchaus variieren kann. unbehandelte und fortschreitende Darm anderen parenchymatösen Organen teils vollständiger architektonischer Dekonstruktion Ablagerung von Bindegewebe, sukzessivem Funktionsverlust Im Endstadium Leberzirrhose können portale Hypertension, Enzephalopathie, Blutungen Karzinome (hepatozelluläres Karzinom [HCC], intrahepatische cholangiozelluläre [iCCCa]) auftreten. intestinale schwerwiegendsten Komplikationen bei Crohn. Durch neuartige konsequente therapeutische Interventionen fibrotische Prozesse gestoppt reversibel gemacht werden. Neue Forschungstechnologien haben unser Wissen Leberfibrogenese Darmfibrose erheblich verbessert. Der Schwerpunkt dieser Übersichtsarbeit liegt auf MASLD dem Crohn, chronischen entzündlichen Erkrankungen Leber steigender Prävalenz großen Auswirkungen Allgemeinbevölkerung. aktuellen Grundlagen potenziellen Möglichkeiten präventiver therapeutischer antifibrotischer werden illustriert.

Процитировано

0