Prediction of Microvascular Adaptation to Hypoxia Based on Myogenic Microcirculation Oscillations DOI Creative Commons
Andrzej Marcinek, Joanna Katarzyńska, Agata Stanek

и другие.

Sensors, Год журнала: 2025, Номер 25(9), С. 2751 - 2751

Опубликована: Апрель 26, 2025

Microcirculatory oscillations known as flowmotion are a recognized feature of blood flow that reflect the functional state vascular system. Many diseases associated with impaired flowmotion, especially accompanied by hypoxia. Low-frequency myogenic (0.052-0.15 Hz) an important regulator microvascular adaptation to Here, we study component using FMSF-PORH (Flow Mediated Skin Fluorescence-Post Occlusive Reactive Hyperemia) technique. Myogenic were strongly activated under hypoxic conditions caused occlusion brachial artery or intermittent treatment. A strong correlation was noted between hypoxia sensitivity parameter HS (the intensity hypoxia) and normoxic VM conditions). If is considered direct measure microcirculation response hypoxia, then can be microcirculation's readiness provide this response. The predictive value presented. assessment activity normoxia could thus simple rapid diagnostic tool for health care practitioners.

Язык: Английский

Simultaneous assessment of mitochondrial and vascular function using the Flow Mediated Skin Fluorescence technique DOI Creative Commons
Andrzej Marcinek, Joanna Katarzyńska, Jerzy Gębicki

и другие.

Frontiers in Physiology, Год журнала: 2025, Номер 16

Опубликована: Фев. 19, 2025

Flow Mediated Skin Fluorescence (FMSF) is a new non-invasive diagnostic method for assessing vascular circulation and/or metabolic regulation. The measures stimulation of the in response to post-occlusive reactive hyperemia (PORH). It analyzes dynamical changes NADH fluorescence emitted from skin tissue, providing information on mitochondrial status and intracellular oxygen delivery through circulatory system. Assessment state using FMSF technique based three parameters: flowmotion (FM) under normoxia conditions, hypoxia sensitivity (HS), hyperemic (HRmax). functioning mitochondria can be assessed by analyzing ischemic (IRmax), basal level fluorescence. There close relationship between Despite these interactions, regulatory function monitored separately as well simultaneously technique. Uniquely, this approach delivers both single measurement.

Язык: Английский

Процитировано

2
Prediction of Microvascular Adaptation to Hypoxia Based on Myogenic Microcirculation Oscillations DOI Creative Commons
Andrzej Marcinek, Joanna Katarzyńska, Agata Stanek

и другие.

Sensors, Год журнала: 2025, Номер 25(9), С. 2751 - 2751

Опубликована: Апрель 26, 2025

Microcirculatory oscillations known as flowmotion are a recognized feature of blood flow that reflect the functional state vascular system. Many diseases associated with impaired flowmotion, especially accompanied by hypoxia. Low-frequency myogenic (0.052-0.15 Hz) an important regulator microvascular adaptation to Here, we study component using FMSF-PORH (Flow Mediated Skin Fluorescence-Post Occlusive Reactive Hyperemia) technique. Myogenic were strongly activated under hypoxic conditions caused occlusion brachial artery or intermittent treatment. A strong correlation was noted between hypoxia sensitivity parameter HS (the intensity hypoxia) and normoxic VM conditions). If is considered direct measure microcirculation response hypoxia, then can be microcirculation's readiness provide this response. The predictive value presented. assessment activity normoxia could thus simple rapid diagnostic tool for health care practitioners.

Язык: Английский

Процитировано

0