Antibiotic use at the Centre Hospitalier Universitaire de Zone d'Abomey Calavi/Sô-Ava (CHUZ/AS) in Benin: a point prevalence survey DOI Creative Commons

Morelle Sèssiwèdé Gnimavo,

Bawa Boya, Steward Mudenda

и другие.

JAC-Antimicrobial Resistance, Год журнала: 2024, Номер 7(1)

Опубликована: Дек. 26, 2024

Abstract Background Antimicrobial stewardship promotes the appropriate use of antibiotics to prevent emergence and spread antimicrobial resistance. This study evaluated using a point prevalence survey at Centre Hospitalier Universitaire de Zone d'Abomey Calavi/Sô-Ava (CHUZ/AS) in Benin. Methods cross-sectional utilized WHO methodology for monitoring antibiotic among inpatients hospitals. The was conducted from 11 January 2022 19 hospitalized patients before 8:00 a.m. on day survey. Results Of 111 inpatient medical files reviewed, 82.9%. number received per patient ranged 1 5, with mean 2.45 ± 1.11 median 2. most commonly prescribed class beta-lactams (46.7%), aminoglycosides (20.6%) nitroimidazoles (19.7%). According AWaRe classification, 30.4% Access group 44% combination Watch antibiotics; treatment empiric 94.5% encounters. Only 22.7% were treated based microbiological examination/culture sensitivity testing. Conclusions found high CHUZ/AS Tertiary Care Hospital ampicillin, metronidazole ceftriaxone. Consequently, low culture testing guide treatment, particularly paediatric surgical population, preference broad-spectrum suggests that is not optimal. Therefore, programmes, policies guidelines must be instigated strengthened address these gaps promote rational antibiotics.

Язык: Английский

Surveillance of Antibiotic Use and Adherence to the WHO/INRUD Core Prescribing Indicators at a Primary Healthcare Hospital in Southern Zambia: Opportunities for Antimicrobial Stewardship Programs DOI Open Access
Steward Mudenda,

Ronald Simbaya,

Given Moonga

и другие.

Pharmacology &amp Pharmacy, Год журнала: 2025, Номер 16(01), С. 1 - 19

Опубликована: Янв. 1, 2025

Background: The irrational use of medicines remains a key health problem in many developing countries. overuse antibiotics is driver antimicrobial resistance (AMR). This study surveyed antibiotic and adherence to the World Health Organization (WHO) prescribing indicators at Request Muntanga Hospital Kalomo District Southern Province, Zambia. Materials Methods: cross-sectional was conducted from July 2023 September Zambia reviewed 600 medical record prescriptions which were issued 1, 2022 June 30, using WHO indicators. collected data analyzed Statistical Package for Social Sciences version 23.0. Results: From sampled, 1246 prescribed, with making up 86.7% encounters. Additionally, average number drugs prescribed per encounter 2.1 prevalence polypharmacy 61.3%. Further, 17.8% as injectables. Furthermore, 76.7% Essential Medicines List 38.9% by generic names. Conclusions: found high deviations WHO/International Network Rational Use Drugs (INRUD) core indicating non-adherence There need promote WHO/INRUD rational prevent emergence spread AMR.

Язык: Английский

Процитировано

1
Point Prevalence Survey of Antibiotic Use in Level 1 hospitals in Zambia: Future Prospects for Antimicrobial Stewardship Programs DOI Creative Commons
Steward Mudenda, Adriano Focus Lubanga, Shazia Jamshed

и другие.

Infection and Drug Resistance, Год журнала: 2025, Номер Volume 18, С. 887 - 902

Опубликована: Фев. 1, 2025

The inappropriate prescribing and use of antibiotics have contributed to the emergence spread antimicrobial resistance (AMR). In Zambia, there is a paucity information on patterns among hospitalized patients in level 1 hospitals. This study investigated antibiotic five hospitals Lusaka, Zambia. cross-sectional utilized World Health Organization (WHO) Point Prevalence Survey (PPS) methodology in-patients admitted before 08:00 a.m. survey day August 2024. Data were analysed using IBM SPSS version 23.0. prevalence inpatients was 59.0%, with ceftriaxone being most prescribed. Antibiotics prescribed mainly for paediatrics male inpatients. found that 53.0% from Access group while 38.2% Watch Access, Watch, Reserve (AWaRe) classification. Adherence national treatment guidelines 36.0%, empirically without evidence culture sensitivity tests. high low adherence findings this demonstrate need establish strengthen stewardship programs laboratory capacity aid clinicians diagnosing, treating, managing across

Язык: Английский

Процитировано

1
Pollution by Antimicrobials and Antibiotic Resistance Genes in East Africa: Occurrence, Sources, and Potential Environmental Implications DOI Creative Commons

Miraji Hossein,

Asha Ripanda

Toxicology Reports, Год журнала: 2025, Номер 14, С. 101969 - 101969

Опубликована: Фев. 22, 2025

Язык: Английский

Процитировано

1
Current status and future direction of antimicrobial stewardship programs and antibiotic prescribing in primary care hospitals in Zambia DOI Creative Commons

Faustina Makiko,

Aubrey Chichonyi Kalungia, Martin Kampamba

и другие.

JAC-Antimicrobial Resistance, Год журнала: 2025, Номер 7(3)

Опубликована: Апрель 29, 2025

Antimicrobial Stewardship Programs (ASPs) intended to optimize antibiotic use will be more effective if informed by the current status and patterns of utilisation. In Zambia's primary healthcare (PHC) settings, data on ASPs utilisation were inadequate guide improvements. As a first step, this study assessed prescribing ASP core elements among PHC first-level hospitals (FLHs) in Zambia. A point prevalence survey was conducted at five FLHs Lusaka using Global-PPS® protocol. Hospital evaluated included hospital leadership commitment, accountability, pharmacy expertise, action, tracking, reporting, education. Antibiotic 79.8% (146/183). total 220 prescription encounters recorded inpatients, with ceftriaxone (J01DD04, Watch) being most (50.0%) prescribed. Over 90.0% (202) prescriptions targeted suspected community-acquired infections, but only 36.8% (81) compliant national treatment guidelines. element implementation 36.0% (16.2/45), two achieving over 50.0%. The deficient reporting. providing sub-optimal, high rates, frequent broad-spectrum Watch group antibiotics, low compliance key ways forward, require strengthening adapting WHO AWaRe recommendations improving actions, reporting improve stewardship practice reduce AMR.

Язык: Английский

Процитировано

1
Antimicrobial Stewardship Impact on Antibiotic Use in Three Tertiary Hospitals in Zambia: A Comparative Point Prevalence Survey DOI Creative Commons
Steward Mudenda,

Kenneth Kapolowe,

Uchizi Chirwa

и другие.

Antibiotics, Год журнала: 2025, Номер 14(3), С. 284 - 284

Опубликована: Март 10, 2025

Introduction: Antimicrobial stewardship (AMS) can improve the rational use of antibiotics in hospitals. This study assessed impact a multifaceted AMS intervention on antibiotic and prescribing patterns at three tertiary hospitals Zambia. Methods: Point Prevalence Surveys (PPS) were conducted August 2022 October 2023. It was part 3-year demonstration project that aimed to optimize treating urinary tract infections (UTIs) bloodstream (BSIs) various health sector settings Up 170 medical records 265 2023 included assessment. Results: Overall, prevalence this PPS 75%. Eighty-one percent (81%) 71% patients least one 2023, respectively, indicating decrease 10%. Similarly, ceftriaxone, most prescribed antibiotic, declined from an average 48% 38% Adherence Standard Treatment Guidelines (STGs) slightly increased 42% 45% Additionally, reduced 1.38 1.21. Conclusions: had early positive adherence Guidelines.

Язык: Английский

Процитировано

0
GLOBAL TRENDS, RISK FACTORS, AND CHALLENGES IN DRUG-RESISTANT TUBERCULOSIS: A SYSTEMATIC REVIEW OF ANTIMICROBIAL RESISTANCE PATTERNS AND DETERMINANTS DOI Creative Commons

Ruth Chipampe Kafwanka,

Rogers Chilyabanyama,

Richard Chirwa

и другие.

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Antibiotic use at the Centre Hospitalier Universitaire de Zone d'Abomey Calavi/Sô-Ava (CHUZ/AS) in Benin: a point prevalence survey DOI Creative Commons

Morelle Sèssiwèdé Gnimavo,

Bawa Boya, Steward Mudenda

и другие.

JAC-Antimicrobial Resistance, Год журнала: 2024, Номер 7(1)

Опубликована: Дек. 26, 2024

Abstract Background Antimicrobial stewardship promotes the appropriate use of antibiotics to prevent emergence and spread antimicrobial resistance. This study evaluated using a point prevalence survey at Centre Hospitalier Universitaire de Zone d'Abomey Calavi/Sô-Ava (CHUZ/AS) in Benin. Methods cross-sectional utilized WHO methodology for monitoring antibiotic among inpatients hospitals. The was conducted from 11 January 2022 19 hospitalized patients before 8:00 a.m. on day survey. Results Of 111 inpatient medical files reviewed, 82.9%. number received per patient ranged 1 5, with mean 2.45 ± 1.11 median 2. most commonly prescribed class beta-lactams (46.7%), aminoglycosides (20.6%) nitroimidazoles (19.7%). According AWaRe classification, 30.4% Access group 44% combination Watch antibiotics; treatment empiric 94.5% encounters. Only 22.7% were treated based microbiological examination/culture sensitivity testing. Conclusions found high CHUZ/AS Tertiary Care Hospital ampicillin, metronidazole ceftriaxone. Consequently, low culture testing guide treatment, particularly paediatric surgical population, preference broad-spectrum suggests that is not optimal. Therefore, programmes, policies guidelines must be instigated strengthened address these gaps promote rational antibiotics.

Язык: Английский

Процитировано

2