Evaluation of the Antidiabetic Potential of Methanolic Extract of Clerodendrum infortunatum Compared to Metformin in Streptozotocin-induced Diabetic Rats DOI
Manish Kumar, Pankaj Prabhakar,

Saajid Hameed

и другие.

International Journal of Applied and Basic Medical Research, Год журнала: 2025, Номер 15(2), С. 78 - 84

Опубликована: Апрель 1, 2025

Abstract Background: Diabetes mellitus is a prevalent metabolic disorder characterized by reduced insulin activity leading to hyperglycemia, affecting over 425 million people globally. Traditional treatments, including sulfonylureas and biguanides, often have undesirable side effects, prompting shift toward herbal remedies for diabetes management prevention. Objective: This study aims evaluate the antidiabetic effects of budding leaves from Clerodendrum infortunatum compared metformin in preventing streptozotocin (STZ)-induced hyperglycemia rats. Materials Methods: An vivo was conducted using adult male Wistar albino STZ administered on day 15 followed till 18. Methanolic extract C. (MECI) at different dosages (250, 500, 1000 mg), (500 normal saline were groups Blood glucose levels (at 1, 15, 18) biochemical parameters (lipid profile, hepatic renal parameters, oxidative stress markers) measured days 1 At end, histopathological examination pancreas, liver, kidney done. Statistical analyses performed determine significance. Results: The found that while MECI 500 mg/kg showed significant reduction blood diabetic control group ( P < 0.0001), it less effective than > 0.05). Higher doses demonstrated potential improving liver as well reducing 0.0001) indicating its beneficial conditions. Conclusion: shows promise an adjunctive therapy prevention due multifaceted mechanisms, enhancing secretion stress. However, further clinical trials are needed confirm these findings establish optimal dosages.

Язык: Английский

Evaluation of the Antidiabetic Potential of Methanolic Extract of Clerodendrum infortunatum Compared to Metformin in Streptozotocin-induced Diabetic Rats DOI
Manish Kumar, Pankaj Prabhakar,

Saajid Hameed

и другие.

International Journal of Applied and Basic Medical Research, Год журнала: 2025, Номер 15(2), С. 78 - 84

Опубликована: Апрель 1, 2025

Abstract Background: Diabetes mellitus is a prevalent metabolic disorder characterized by reduced insulin activity leading to hyperglycemia, affecting over 425 million people globally. Traditional treatments, including sulfonylureas and biguanides, often have undesirable side effects, prompting shift toward herbal remedies for diabetes management prevention. Objective: This study aims evaluate the antidiabetic effects of budding leaves from Clerodendrum infortunatum compared metformin in preventing streptozotocin (STZ)-induced hyperglycemia rats. Materials Methods: An vivo was conducted using adult male Wistar albino STZ administered on day 15 followed till 18. Methanolic extract C. (MECI) at different dosages (250, 500, 1000 mg), (500 normal saline were groups Blood glucose levels (at 1, 15, 18) biochemical parameters (lipid profile, hepatic renal parameters, oxidative stress markers) measured days 1 At end, histopathological examination pancreas, liver, kidney done. Statistical analyses performed determine significance. Results: The found that while MECI 500 mg/kg showed significant reduction blood diabetic control group ( P < 0.0001), it less effective than > 0.05). Higher doses demonstrated potential improving liver as well reducing 0.0001) indicating its beneficial conditions. Conclusion: shows promise an adjunctive therapy prevention due multifaceted mechanisms, enhancing secretion stress. However, further clinical trials are needed confirm these findings establish optimal dosages.

Язык: Английский

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