Pharmacological Evaluation of Novel Hydrazide and Hydrazone Derivatives: Anti-Inflammatory and Analgesic Potential in Preclinical Models DOI Creative Commons
H. Zlatanova, Stanislava Vladimirova

Molecules, Год журнала: 2025, Номер 30(7), С. 1472 - 1472

Опубликована: Март 26, 2025

Hydrazones, characterized by their C=N–NH functional group, are promising candidates in medicinal chemistry due to ability interact with biological targets. This study evaluated the anti-inflammatory and analgesic properties of N-pyrrolylcarbohydrazide (1) four pyrrole hydrazone derivatives (1A–D) male Wistar rats (6 weeks old). Anti-inflammatory activity was assessed using a carrageenan-induced paw edema model, while formalin, tail flick, withdrawal tests analgesia. Compound 1 exhibited dose-dependent activity. At 20 mg/kg, significant reductions were observed at 2nd (p = 0.035) 3rd hours 0.022), 40 remained 0.008) 0.046). 1A showed pronounced effects mg/kg 0.005), < 0.001), 4th 0.004). Other compounds demonstrated minimal or no Analgesic evaluation revealed that compound significantly reduced paw-licking time second phase 0.038). Compounds 1B, 1C, 1D transient first only 0.05). lacked The findings suggest structural modifications may enhance efficacy for broader therapeutic applications.

Язык: Английский

Pharmacological Evaluation of Novel Hydrazide and Hydrazone Derivatives: Anti-Inflammatory and Analgesic Potential in Preclinical Models DOI Creative Commons
H. Zlatanova, Stanislava Vladimirova

Molecules, Год журнала: 2025, Номер 30(7), С. 1472 - 1472

Опубликована: Март 26, 2025

Hydrazones, characterized by their C=N–NH functional group, are promising candidates in medicinal chemistry due to ability interact with biological targets. This study evaluated the anti-inflammatory and analgesic properties of N-pyrrolylcarbohydrazide (1) four pyrrole hydrazone derivatives (1A–D) male Wistar rats (6 weeks old). Anti-inflammatory activity was assessed using a carrageenan-induced paw edema model, while formalin, tail flick, withdrawal tests analgesia. Compound 1 exhibited dose-dependent activity. At 20 mg/kg, significant reductions were observed at 2nd (p = 0.035) 3rd hours 0.022), 40 remained 0.008) 0.046). 1A showed pronounced effects mg/kg 0.005), < 0.001), 4th 0.004). Other compounds demonstrated minimal or no Analgesic evaluation revealed that compound significantly reduced paw-licking time second phase 0.038). Compounds 1B, 1C, 1D transient first only 0.05). lacked The findings suggest structural modifications may enhance efficacy for broader therapeutic applications.

Язык: Английский

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