Cancers,
Год журнала:
2021,
Номер
13(9), С. 2036 - 2036
Опубликована: Апрель 23, 2021
Natural
compounds
such
as
essential
oils
and
tea
have
been
used
successfully
in
naturopathy
folk
medicine
for
hundreds
of
years.
Current
research
is
unveiling
the
molecular
role
their
antibacterial,
anti-inflammatory,
anticancer
properties.
Nevertheless,
effect
these
on
bacteriophages
still
poorly
understood.
The
application
against
bacteria
has
gained
a
particular
interest
recent
years
due
to,
e.g.,
constant
rise
antimicrobial
resistance
to
antibiotics,
or
an
increasing
awareness
different
types
microbiota
potential
contribution
gastrointestinal
diseases,
including
inflammatory
malignant
conditions.
Thus,
better
knowledge
how
dietary
products
can
affect
and,
turn,
whole
gut
microbiome
help
maintain
healthy
homeostasis,
reducing
risk
developing
diseases
diverse
gastroenteritis,
bowel
disease,
even
cancer.
present
review
summarizes
physiology
bacteriophages.
In
majority
works,
substance
class
polyphenols
showed
activity
bacteriophages,
primary
mechanism
action
involved
structural
damage
capsid,
inhibiting
bacteriophage
infectivity.
Some
further
caffeine,
salt
oregano
shown
induce
suppress
prophages,
whereas
others,
natural
sweeter
stevia,
promoted
species-specific
phage
responses.
A
understanding
could
selectively,
specifically,
modulate
individual
phages
opens
possibility
reorganize
microbial
network
additional
strategy
support
combat,
prevention,
inflammation
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(23), С. 14837 - 14837
Опубликована: Ноя. 27, 2022
Insufficient
sleep
is
becoming
increasingly
common
and
contributes
to
many
health
issues.
To
combat
sleepiness,
caffeine
consumed
daily
worldwide.
Thus,
consumption
restriction
often
occur
in
succession.
The
gut
microbiome
can
be
rapidly
affected
by
either
one’s
status
or
intake,
whereas
the
synergistic
effects
of
a
persistent
caffeine-induced
remain
unclear.
In
this
study,
we
investigated
impact
chronic
on
its
metabolic
profiles
mice.
Our
results
revealed
that
proportion
Firmicutes
Bacteroidetes
was
not
altered,
while
abundance
Proteobacteria
Actinobacteria
significantly
decreased.
addition,
content
lipids
abundant
increased.
A
pathway
analysis
differential
metabolites
suggested
numerous
pathways
were
affected,
glycerophospholipid
metabolism
most
altered.
Combined
variations
function
intestinal
microorganisms
closely
relevant
Actinobacteria.
conclusion,
long-term
diversity
composition
microbiota
mice,
substantially
altered
microbiome.
This
may
represent
novel
mechanism
which
an
unhealthy
lifestyle
such
as
mistimed
coffee
breaks
lead
exacerbates
disease.
Cancer Epidemiology Biomarkers & Prevention,
Год журнала:
2022,
Номер
32(2), С. 217 - 225
Опубликована: Сен. 21, 2022
Abstract
Background:
Incidence
of
early-onset
colorectal
cancer
(EOCRC;
e.g.,
diagnosed
before
age
50)
in
the
United
States
has
increased
substantially
since
1990s
but
underlying
reasons
remain
unclear.
Methods:
We
examined
ecologic
associations
between
dietary
factors
and
EOCRC
incidence
adults
aged
25–49
during
1977–2016
States,
using
negative
binomial
regression
models,
accounting
for
age,
period,
race.
The
models
also
incorporated
an
age-mean
centering
(AMC)
approach
to
address
potential
confounding
by
age.
stratified
analysis
sex
computed
rate
ratio
(IRR)
each
study
factor.
Study
factor
data
(for
18
variables)
came
from
repeated
national
surveys;
Surveillance
Epidemiology,
End
Results
Program.
Results:
suggest
that
on
association
with
likely
existed
certain
(e.g.,
calcium
intake),
AMC
can
alleviate
confounding.
was
positively
associated
smoking
[IRR
(95%
confidence
interval
(CI):
1.17
(1.10–1.24)
men;
1.15
(1.09–1.21)
women]
alcohol
consumption
CI),
1.08
(1.04–1.12)
(1.04–1.11)
women].
No
strong
were
found
most
other
fiber
calcium).
Conclusions:
Alcohol
among
young
1980s,
which
may
have
contributed
increases
1990s.
help
similar
analyses.
Impact:
Increases
recent
adults.
See
related
commentary
Ni
et
al.,
p.
164
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(24), С. 15447 - 15447
Опубликована: Дек. 7, 2022
Claudin-2
(CLDN2),
a
component
of
tight
junctions,
is
abnormally
expressed
in
human
lung
adenocarcinoma
tissue.
CLDN2
contributes
to
chemoresistance
adenocarcinoma-derived
A549
cells,
and
it
may
be
target
for
cancer
therapy.
Here,
we
found
that
coffee
ingredients,
namely
caffeine
theobromine,
decreased
the
protein
level
cells.
In
contrast,
other
components,
such
as
theophylline
chlorogenic
acid,
had
no
effect.
These
results
indicate
7-methyl
group
methylxanthines
play
key
role
reduction
expression.
The
caffeine-induced
was
inhibited
by
chloroquine,
lysosome
inhibitor.
protein-stability
assay
using
cycloheximide,
levels
faster
caffeine-treated
cells
than
vehicle-treated
suggest
accelerates
lysosomal
degradation
CLDN2.
accumulation
cytotoxicity
doxorubicin
were
dose-dependently
increased,
which
exaggerated
but
not
spheroids.
Caffeine
nuclear
factor-erythroid
2-related
factor
2
(Nrf2)
without
affecting
hypoxia-inducible
factor-1α
levels.
Furthermore,
expression
Nrf2-targeted
genes.
effects
on
anticancer-drug-induced
toxicity
also
observed
RERF-LC-MS
We
enhances
doxorubicin-induced
spheroids
mediated
Nrf2
Rapid Communications in Mass Spectrometry,
Год журнала:
2023,
Номер
37(6)
Опубликована: Янв. 3, 2023
Rationale
Nasopharyngeal
carcinoma
(NPC)
is
a
malignant
tumor
that
endemic
in
Southeast
Asia,
North
Africa,
and
southern
China.
There
an
urgent
need
for
effective
early
diagnosis
treatment
of
this
disease
since
NPC
currently
often
detected
at
advanced
stages.
Methods
To
reveal
the
underlying
metabolic
mechanisms
discover
potential
diagnostic
biomarkers
NPC,
we
employed
ultrahigh‐performance
liquid
chromatography
coupled
with
quadrupole
time‐of‐flight
mass
spectrometry
(UHPLC‐Q‐TOF‐MS)
UHPLC‐Q‐Exactive
Orbitrap
MS,
respectively,
to
analyze
54
serum
samples
urine
from
27
patients
healthy
control
individuals.
Results
A
total
1230
metabolites
were
determined
samples,
181
significantly
changed
patients.
The
enriched
16
pathways,
including
biosynthesis
unsaturated
fatty
acids,
cholesterol
metabolism,
ferroptosis.
2509
samples.
Among
them,
179
altered
patients,
these
eight
tricarboxylic
acid
(TCA)
cycle
caffeine
metabolism.
Seven
metabolites,
creatinine
paraxanthine,
found
be
both
Based
on
further
biomarker
analysis
revealed
panel
three
octanoylcarnitine,
creatinine,
decanoyl‐l‐carnitine,
displayed
perfect
performance
(area
under
curve
[AUC]
=
0.973)
distinguish
controls,
while
other
three‐metabolite
panel,
consisting
stachydrine,
had
AUC
0.809
Conclusion
This
work
highlights
key
pathways
disturbed
presents
disease.
Cancers,
Год журнала:
2021,
Номер
13(9), С. 2036 - 2036
Опубликована: Апрель 23, 2021
Natural
compounds
such
as
essential
oils
and
tea
have
been
used
successfully
in
naturopathy
folk
medicine
for
hundreds
of
years.
Current
research
is
unveiling
the
molecular
role
their
antibacterial,
anti-inflammatory,
anticancer
properties.
Nevertheless,
effect
these
on
bacteriophages
still
poorly
understood.
The
application
against
bacteria
has
gained
a
particular
interest
recent
years
due
to,
e.g.,
constant
rise
antimicrobial
resistance
to
antibiotics,
or
an
increasing
awareness
different
types
microbiota
potential
contribution
gastrointestinal
diseases,
including
inflammatory
malignant
conditions.
Thus,
better
knowledge
how
dietary
products
can
affect
and,
turn,
whole
gut
microbiome
help
maintain
healthy
homeostasis,
reducing
risk
developing
diseases
diverse
gastroenteritis,
bowel
disease,
even
cancer.
present
review
summarizes
physiology
bacteriophages.
In
majority
works,
substance
class
polyphenols
showed
activity
bacteriophages,
primary
mechanism
action
involved
structural
damage
capsid,
inhibiting
bacteriophage
infectivity.
Some
further
caffeine,
salt
oregano
shown
induce
suppress
prophages,
whereas
others,
natural
sweeter
stevia,
promoted
species-specific
phage
responses.
A
understanding
could
selectively,
specifically,
modulate
individual
phages
opens
possibility
reorganize
microbial
network
additional
strategy
support
combat,
prevention,
inflammation
