Natural Alternatives in the Treatment of Colorectal Cancer: A Mechanisms Perspective
Biomolecules,
Год журнала:
2025,
Номер
15(3), С. 326 - 326
Опубликована: Фев. 24, 2025
Colorectal
cancer
(CRC)
is
one
of
the
deadliest
neoplasia.
Intrinsic
or
acquired
resistance
main
cause
failure
therapy
regimens
that
leads
to
relapse
and
death
in
CRC
patients.
The
widely
used
chemotherapeutic
agent
5-fluorouracil
(5-FU)
remains
mainstay
for
therapeutic
combinations.
Unfortunately,
side
effects
are
frequent
events
compromise
success
these
therapies;
dysregulation
enzymes
regulate
5-FU
metabolism
increases
expression
activity
efflux
pumps.
Additional
tumor
cell
adaptations
such
as
epithelial–mesenchymal
transition
(EMT),
autophagy
shaping
microenvironment,
inflammation
contribute
chemoresistance.
Finding
new
strategies
alternatives
enhance
conventional
chemotherapies
has
become
necessary.
Recently,
study
natural
compounds
been
gaining
strength
an
alternative
chemotherapeutics
different
cancers.
Curcumin,
trimethylglycine,
resveratrol,
artemisinin,
some
helminth-derived
molecules,
among
others,
studied
context
CRC.
This
review
discusses
benefits,
mechanisms,
advances,
dark
currently
evaluated
treatment.
We
also
analyzed
landscape
non-conventional
their
underlying
mechanisms
action,
which
could,
short
term,
provide
fundamental
knowledge
harness
anti-tumor
allow
them
be
adjuvant
therapies.
Язык: Английский
CNPY3’s regulation of tumor microenvironment and its impact on colon cancer aggressiveness
Molecular Medicine,
Год журнала:
2025,
Номер
31(1)
Опубликована: Март 7, 2025
Abstract
Background
Canopy
FGF
signaling
regulator
3
(CNPY3)
has
been
implicated
in
tumor
progression.
However,
its
specific
role
colon
cancer
(CC)
remains
unclear.
This
study
aims
to
investigate
the
function
of
CNPY3
CC
and
potential
as
a
therapeutic
target.
Methods
A
total
201
tissue
specimens
67
adjacent
non-cancerous
tissues
were
collected
for
analysis.
expression
was
assessed
using
immunohistochemistry
quantitative
real-time
PCR.
Functional
assays
conducted
cell
lines
(HT-29
SW-620)
following
knockdown
evaluate
effects
on
proliferation,
migration,
apoptosis.
Gene
profiling,
fibroblast
co-culture
experiments,
vivo
xenograft
models
also
conducted.
Results
Increased
correlated
with
advanced
stages
poorer
prognosis.
Knockdown
significantly
inhibited
induced
apoptosis
lines.
depletion
modulated
behavior,
inhibiting
their
transformation
into
cancer-associated
fibroblasts.
Pathway
analysis
revealed
that
affected
cycle
p53
pathways,
reduced
activation
MAPK
PI3K/AKT
pathways.
Additionally,
enhanced
sensitivity
5-fluorouracil.
In
studies
demonstrated
resulted
smaller
sizes
weights
than
controls.
Conclusions
is
crucial
progression,
correlating
aggressiveness
poor
patient
outcomes.
Targeting
may
offer
promising
strategy
valuable
prognostic
marker
management.
Язык: Английский