Pharmacokinetic characteristics of mesenchymal stem cells in translational challenges

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Сен. 13, 2024

Язык: Английский

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Priming mesenchymal stem cells to develop “super stem cells”

World Journal of Stem Cells, Год журнала: 2024, Номер 16(6), С. 623 - 640

Опубликована: Июнь 24, 2024

The stem cell pre-treatment approaches at cellular and sub-cellular levels encompass physical manipulation of cells to growth factor treatment, genetic manipulation, chemical pharmacological each strategy having advantages limitations. Most these protocols are non-combinative. This editorial is a continuum Li

Язык: Английский

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Tissue-source effect on mesenchymal stem cells as living biodrugs for heart failure: Systematic review and meta-analysis

World Journal of Cardiology, Год журнала: 2024, Номер 16(8), С. 469 - 483

Опубликована: Авг. 26, 2024

Mesenchymal stem cells (MSCs), as living biodrugs, have entered advanced phases of clinical assessment for cardiac function restoration in patients with myocardial infarction and heart failure. While MSCs are available from diverse tissue sources, bone-marrow-derived (BM-MSCs) remain the most well-studied cell type, besides umbilical-cord-derived (UC-MSCs). The latter offers advantages, including noninvasive availability without ethical considerations.

Язык: Английский

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Pretreatment can alleviate programmed cell death in mesenchymal stem cells

World Journal of Stem Cells, Год журнала: 2024, Номер 16(8), С. 773 - 779

Опубликована: Авг. 26, 2024

In this editorial, we delved into the article titled “Cellular preconditioning and mesenchymal stem cell ferroptosis.” This groundbreaking study underscores a pivotal discovery: Ferroptosis, type of programmed death, drastically reduces viability donor cells (MSCs) after engraftment, thereby undermining therapeutic value cell-based therapies. Furthermore, proposes that by manipulating ferroptosis mechanisms through preconditioning, can potentially enhance survival rate functionality MSCs, ultimately amplifying their potential. Given crucial role plays in shaping outcomes deem it imperative to further investigate intricate interplay between death effectiveness MSCs.

Язык: Английский

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Melatonin-based priming of stem cells to alleviate oxidative stress

World Journal of Stem Cells, Год журнала: 2024, Номер 16(11), С. 985 - 989

Опубликована: Ноя. 25, 2024

Stem cell expansion

Язык: Английский

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