Clinical characteristics of female long COVID patients with menstrual symptoms: a retrospective study from a Japanese outpatient clinic

Journal of Psychosomatic Obstetrics & Gynecology, Год журнала: 2024, Номер 45(1)

Опубликована: Янв. 25, 2024

Purpose To elucidate the impact of long COVID on menstruation and mental health, medical records patients with were evaluated.

Язык: Английский

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Potential Beneficial Effects of Naringin and Naringenin on Long COVID—A Review of the Literature

Microorganisms, Год журнала: 2024, Номер 12(2), С. 332 - 332

Опубликована: Фев. 4, 2024

Coronavirus disease 2019 (COVID-19) caused a severe epidemic due to acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Recent studies have found that patients do not completely recover from infections, but instead, suffer variety of post-acute sequelae SARS-CoV-2 infection, known as long COVID. The effects COVID can be far-reaching, with duration up six months and range symptoms such cognitive dysfunction, immune dysregulation, microbiota dysbiosis, myalgic encephalomyelitis/chronic fatigue syndrome, myocarditis, pulmonary fibrosis, cough, diabetes, pain, reproductive thrombus formation. However, recent shown naringenin naringin palliative on various COVID-19 sequelae. Flavonoids naringenin, commonly in fruits vegetables, positive effects, including reducing inflammation, preventing viral providing antioxidants. This article discusses the molecular mechanisms clinical treating above diseases. It proposes them potential drugs for treatment COVID, it inferred exhibit extended medications, future likely serving nutraceuticals or supplements comprehensive alleviation manifestations complications.

Язык: Английский

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Post-pandemic insights on COVID-19 and premature ovarian insufficiency

Open Life Sciences, Год журнала: 2025, Номер 20(1)

Опубликована: Янв. 1, 2025

The COVID-19 pandemic has raised concerns regarding its potential impact on premature ovarian insufficiency (POI). This overview examines the possible interactions between and POI, while also suggesting preventive measures. viral infection's inflammatory response immune dysregulation may adversely affect tissues, leading to inflammation damage. Additionally, alterations in vascular function could impair blood flow hormonal imbalances disrupt normal function. Long-term health effects, such as "long COVID," exacerbate these issues through chronic dysfunction. Public measures, vaccination home isolation, indirectly protect by reducing systemic inflammation. Vaccines mitigate severity of COVID-19's function, isolation reduce stress However, further research is needed validate mechanisms.

Язык: Английский

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A multidisciplinary review of long COVID to address the challenges in diagnosis and updated management guidelines

Annals of Medicine and Surgery, Год журнала: 2025, Номер 87(4), С. 2105 - 2117

Опубликована: Фев. 27, 2025

Long COVID has emerged as a significant challenge since the COVID-19 pandemic, which was declared an outbreak in March 2020, marked by diverse symptoms and prolonged duration of disease. Defined WHO persisting or emerging for at least two months post-SARS-CoV-2 infection without alternative cause, its prevalence varies globally, with estimates 10–20% Europe, 7.3% USA, 3.0% UK. The condition’s etiology remains unclear, involving factors, such renin–angiotensin system overactivation, persistent viral reservoirs, immune dysregulation, autoantibodies. Reactivated viruses, like EBV HSV-6, alongside epigenetic alterations, exacerbate mitochondrial dysfunction energy imbalance. Emerging evidence links SARS-CoV-2 to chromatin gut microbiome changes, further influencing long-term health impacts. Diagnosis long requires detailed systemic evaluation through medical history physical examination. Management is highly individualized, focusing mainly on patient’s affected systems. A multidisciplinary approach essential, integrating perspectives address manifestations, underlying mechanisms, therapeutic strategies. Enhanced understanding COVID’s pathophysiology clinical features critical improving patient outcomes quality life. With growing number cases expected advancing research disseminating knowledge remain vital developing effective diagnostic management frameworks, ultimately supporting better care individuals.

Язык: Английский

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SARS‐CoV‐2 infection negatively impacts on the quality of embryos by delaying early embryonic development

American Journal of Reproductive Immunology, Год журнала: 2024, Номер 91(3)

Опубликована: Март 1, 2024

Abstract Background The COVID‐19 pandemic is an unprecedented health crisis that has affected in vitro fertilization practices globally. Previous studies have shown SARS‐CoV‐2 impacts the quality of embryos by inducing immunological response infertile patients. In this study, early embryonic development SARS‐CoV‐2‐infected patients was investigated. Methods Sixty‐five infected and 258 controls were involved study. major outcome parameters for cycle analyzed, including number oocytes, maturation available per cycle, embryo morpho kinetic characteristics. Results From infection until oocyte retrieval, it took average 6.63 days. results revealed oocytes high‐quality on day 3 dramatically reduced detected follicular fluid three had negatively impacted multivariate linear regression models. group a noticeable delay from six‐cell stage to blastocyst stage. Conclusions 3. It delays negative impact embryos.

Язык: Английский

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A retrospective cohort study: is COVID-19 BNT162b2 mRNA vaccination a trigger factor for cluster headache?

Acta Neurologica Belgica, Год журнала: 2024, Номер unknown

Опубликована: Апрель 15, 2024

Язык: Английский

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Effects of the COVID-19 Infection on Women's Menstrual Cycle: A Retrospective Study at Latifa Hospital, Dubai, United Arab Emirates

Cureus, Год журнала: 2023, Номер unknown

Опубликована: Дек. 31, 2023

Background The COVID-19 pandemic has affected all of us in one way or another. menstrual cycle is a reflection the female reproductive system, and it influenced by various factors including stress infections. Although there little information available about how women's health, had significant impact on women. Objective main objective our study to identify if are any disturbances following infection Study design Our retrospective wherein 700 women recovering from were asked new after infection. We collected data using questionnaires analyzed Statistical Product Service Solutions (SPSS, version 26) (IBM SPSS Statistics for Windows, Armonk, NY). Results showed no dysmenorrhea 90% participants, 81% reported change flow rate, vast majority (93%) denied experiencing amenorrhea, only 4% onset intermenstrual bleeding, 1% postmenopausal bleeding. Conclusion There was participants'

Язык: Английский

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Unforeseen effects of COVID-19 on reproductive hormones and health of Indian women

International Journal of Reproduction Contraception Obstetrics and Gynecology, Год журнала: 2024, Номер 13(2), С. 492 - 498

Опубликована: Янв. 29, 2024

Numerous systematic probes, clinical studies and research papers have been published to depict, interpret, explain understand the impacts underlying mechanism of coronavirus disease 2019 (COVID-19) pandemic its long-term effects on female body. COVID-19 affects a number organs, including reproductive function hormonal profile. However, less attention has given system due their low morbidity. The available results involving correlation that infection ovarian holds in women age shown as harmless most cases. Although, several reported involvement oocyte quality, function, dysfunctions uterine endometrium menstrual cycle. findings these indicate negatively follicular microenvironment dysregulate function. Although health studied humans other animals, very few examined how system. Our objective this review is enumerate, illustrate categorize system, ovaries, uterus, profiles. We tried bring forth possible impact may caused from current literature surveys various scientific reports peer reviewed journal articles. maturation, oxidative stress, which causes chromosomal instability apoptosis vitro fertilization cycle, high-quality embryos, premature insufficiency, vein thrombosis, hypercoagulable state, women’s hypothalamus-pituitary-ovary axis, sex hormones, estrogen, progesterone, anti- Müllerian hormone, are circled around here. significantly impacted women. community encourages development recommendations for specialized care strategies prevent respond violence during after pandemic.

Язык: Английский

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Gonadotropin-releasing hormone agonists as a chance for motherhood in the future

Russian Bulletin of Obstetrician-Gynecologist, Год журнала: 2024, Номер 24(2), С. 30 - 30

Опубликована: Янв. 1, 2024

Язык: Английский

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Redox Balance and Inflammatory Response in Follicular Fluids of Women Recovered by SARS-CoV-2 Infection or Anti-COVID-19 Vaccinated: A Combined Metabolomics and Biochemical Study

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(15), С. 8400 - 8400

Опубликована: Авг. 1, 2024

To date, not many studies have presented evidence of SARS-CoV-2 infecting the female reproductive system. Furthermore, so far, no effect administration anti-COVID 19 vaccines has been reported to affect quality oocytes retrieved from women who resorted assisted reproduction technology (ART). The FF metabolic profiles had infected by before IVF treatments or after COVID-19 vaccination were examined 1H NMR. Immunochemical characterization proteins and cytokines involved in redox inflammatory pathways was performed. increased expression SOD2 NQO1, lack alteration IL-6 CXCL10 levels, as well CD39, suggested that, both sharing similar molecular mechanisms proceeding along different routes, balance is controlled vaccinated recovered compared controls. lower amount metabolites known proinflammatory activity, i.e., TMAO lipids, further supported biochemical results, suggesting that microenvironment guarantee oocyte does compromise outcome ART. In terms number blastocysts obtained ICSI pregnancy rate, results are also comforting.

Язык: Английский

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