Integration of cocrystal and nanocrystal techniques to ameliorate solubility, topical antioxidant activity and cytotoxicity of curcumin
Abstract
Curcumin
(CUM),
a
promising
nutraceutical,
exhibits
diverse
pharmacological
activities
such
as
antioxidant,
anti-inflammatory,
antitumor
and
anti-hyperglycemic,
but
the
clinical
applications
of
CUM
is
restricted
by
virtue
its
scarce
aqueous
solubility,
poor
stability
and,
low
oral
topical
absorption.
In
this
work
nano-cocrystal
strategy,
integrating
benefits
cocrystallization
nanocrystal
techniques,
has
been
proposed
to
obtain
superior
characters
CUM.
A
cocrystal
was
successfully
synthesized
with
ascorbic
acid
solvent
evaporation
then
transformed
into
(NCC)
top
down
homogenization
technique
using
poloxamer
188
stabilizer.
NCC
delineated
SEM
Zetasizer
appeared
be
round-shaped
particles
mean
particle
size
200
±
30nm.
Further
characterization
undertaken
PXRD,
DSC
FTIR
spectroscopy.
presented
16
10
fold
enhanced
solubility
dissolution
in
distilled
water
comparison
pure
From
In-vitro
antioxidant
cytotoxicity
studies,
it
suggested
that
displayed
highest
percentage
inhibition
(99.154
0.58%)
IC50
value
1.4
0.180µg/ml
also
led
reduction
viability
MCF-7
breast
cancer
cells.
On
formulating
gel,
stable
for
six
months
at
4
2°C
30
/65
5%
RH.
release
studies
gel
modified
Franz
diffusion
cell
demonstrated
2.4fold
cumulative
compared
gel.
Release
data
best
fitted
Hixon-Crowell
kinetic
model
n
showing
non
Fickian
release.
Hence,
higher
greater
make
formulation.
Research Square (Research Square), Год журнала: 2025, Номер unknown
Опубликована: Май 14, 2025
Язык: Английский