Nickel (II) and Copper (II) Schiff Base Derivatives: Design, Characterization, Biological Activity DOI
Hany M. Abd El‐Lateef, Mai M. Khalaf, Mohamed Gouda

и другие.

ChemistrySelect, Год журнала: 2024, Номер 9(47)

Опубликована: Дек. 1, 2024

Abstract This work presents the designing and characterization of two novel metal complexes derived from a Schiff base, N , ’‐ethane‐1,2‐diylbis[1‐(2‐chloroquinolin‐3‐yl)methanimine] (EBCQ), coordinated with Ni (II) (NiEBCQ), Cu (CuEBCQ). Structures complex derivatives were proposed utilizing variety analytical methods having elemental analysis, ultraviolet‐visible spectroscopy, mass infrared magnetic properties, conductivity measurement, thermal analysis. The obtained data revealed octahedral geometries for both NiEBCQ CuEBCQ complexes, denoted as [Ni(EBCQ)(H 2 O) (Cl) ] [Cu(EBCQ)(H ], respectively. Density functional theory computations employed confirming molecular structures exploring quantum chemical parameters EBCQ its derivatives. anti‐inflammatory results reveal that ligand NiEBCQ, CuEBCQ, exhibit varying degrees inhibition, showing highest potency. achieved 89.80% inhibition at 300 µM, an IC 50 value 86.38 indicating superior activity compared to ( 92.33 µM) 169.07 µM). In antioxidant assays, again showed most pronounced activity, achieving 74.16 outperforming 89.06 101.58 antibacterial tests confirmed complexes' superiority, particularly which displayed excellent against Bacillus cereus ligand. Molecular docking studies targeting specific proteins (5IKT human cyclo‐oxygenase‐2, 5IJT peroxiredoxin 2) performed assess binding affinities interactions propose promising potential application therapeutic agents diverse biological activities. Finally, effectiveness monitored opposed several Gram‐positive Gram‐negative bacteria.

Язык: Английский

Synthesis, Characterization, and Therapeutic Potential of Novel Schiff Base Metal Complexes: Nickel(II) and Copper(II) Complexes Based 2‐[(2‐Chloroquinolin‐3‐yl)methylidene]aminobenzenethiol (CQAT) DOI Open Access
Hany M. Abd El‐Lateef, Mai M. Khalaf,

Mohamed Gouda

и другие.

Applied Organometallic Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Окт. 28, 2024

ABSTRACT This research focused on the design and comprehensive characterization of two novel transition metal complexes derived from symmetrical Schiff base 2‐[(2‐chloroquinolin‐3‐yl)methylidene]aminobenzenethiol (CQAT), coordinated with nickel(II) (NiCQAT) copper(II) (CuCQAT) ions. The structural elucidation these was achieved through a range advanced analytical techniques. Thermal analysis revealed stability decomposition patterns complexes, supporting identification their coordination geometries. collective data indicated that both NiCQAT CuCQAT adopt octahedral coordination, specific formulas [Ni(CQAT) 2 (H O) ] [Cu(CQAT) ], respectively. To complement experimental findings, density functional theory (DFT) calculations were employed. These theoretical confirmed proposed molecular structures provided detailed insights into key quantum chemical parameters, such as HOMO–LUMO energies, orbitals, electronic distributions, which are crucial for understanding complexes' reactivity stability. Furthermore, extensive in vitro biological evaluations conducted to assess anti‐inflammatory antioxidant properties synthesized complexes. assays demonstrated exhibited significantly enhanced bioactivity compared free CQAT ligand, suggesting synergistic effect ligand's efficacy. further explore mode action, docking studies performed targeting proteins—human cyclooxygenase‐2 (PDB ID: 5IKT) human peroxiredoxin 5IJT). simulations valuable binding affinities, interaction amino acid residues involved process, offering molecular‐level potential mechanisms. findings multidisciplinary highlight therapeutic its nickel copper positioning them promising candidates development field medicinal chemistry.

Язык: Английский

Процитировано

0
Exploring the enhanced bioactivity and reactivity of novel Fe(III) and Co(II) complexes incorporating sulfadiazine tetradentate ligand: Structural, DFT, molecular docking, and biological applications DOI
Nadia A. A. Elkanzi, Mha Albqmi,

Ali M. Ali

и другие.

Journal of Molecular Liquids, Год журнала: 2024, Номер unknown, С. 126594 - 126594

Опубликована: Ноя. 1, 2024

Язык: Английский

Процитировано

0
Synthesis and characterization of new Fe(III) and Co(II) complexes based on levofloxacin and imidazole-2-carboxylic acid: Structural analysis and multifaceted in vitro biological activity DOI
Hany M. Abd El‐Lateef, Mai M. Khalaf, Aly Abdou

и другие.

Journal of the Indian Chemical Society, Год журнала: 2024, Номер 102(1), С. 101524 - 101524

Опубликована: Дек. 12, 2024

Язык: Английский

Процитировано

0
Nickel (II) and Copper (II) Schiff Base Derivatives: Design, Characterization, Biological Activity DOI
Hany M. Abd El‐Lateef, Mai M. Khalaf, Mohamed Gouda

и другие.

ChemistrySelect, Год журнала: 2024, Номер 9(47)

Опубликована: Дек. 1, 2024

Abstract This work presents the designing and characterization of two novel metal complexes derived from a Schiff base, N , ’‐ethane‐1,2‐diylbis[1‐(2‐chloroquinolin‐3‐yl)methanimine] (EBCQ), coordinated with Ni (II) (NiEBCQ), Cu (CuEBCQ). Structures complex derivatives were proposed utilizing variety analytical methods having elemental analysis, ultraviolet‐visible spectroscopy, mass infrared magnetic properties, conductivity measurement, thermal analysis. The obtained data revealed octahedral geometries for both NiEBCQ CuEBCQ complexes, denoted as [Ni(EBCQ)(H 2 O) (Cl) ] [Cu(EBCQ)(H ], respectively. Density functional theory computations employed confirming molecular structures exploring quantum chemical parameters EBCQ its derivatives. anti‐inflammatory results reveal that ligand NiEBCQ, CuEBCQ, exhibit varying degrees inhibition, showing highest potency. achieved 89.80% inhibition at 300 µM, an IC 50 value 86.38 indicating superior activity compared to ( 92.33 µM) 169.07 µM). In antioxidant assays, again showed most pronounced activity, achieving 74.16 outperforming 89.06 101.58 antibacterial tests confirmed complexes' superiority, particularly which displayed excellent against Bacillus cereus ligand. Molecular docking studies targeting specific proteins (5IKT human cyclo‐oxygenase‐2, 5IJT peroxiredoxin 2) performed assess binding affinities interactions propose promising potential application therapeutic agents diverse biological activities. Finally, effectiveness monitored opposed several Gram‐positive Gram‐negative bacteria.

Язык: Английский

Процитировано

0