The efficacy and safety of ginkgo terpene lactone preparations combined with antiplatelet aents in the treatment of ischemic stroke: a systematic review and meta-analysis DOI Creative Commons

Xu Hong,

Li Zeng,

Li Liao

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Март 19, 2025

Background This meta-analysis aimed to assess the efficacy and safety of ginkgo terpene lactone preparations including diterpene ginkgolides meglumine injection (DGMI) ginkgolide combined with antiplatelet drugs in treatment ischemic stroke. Methods We systematically searched randomized controlled trials(RCTs) publication date earlier than 6 November 2024 PubMed, China National Knowledge Infrastructure (CNKI), Chinese Science Technology Journal Database (VIP), Biomedical Literature (CBM), Wanfang Database, Embase, Web Science, ClinicalTrials.gov , Cochrane Library. Studies were screened according inclusion exclusion criteria, evaluated criteria recommended by Handbook, data then analyzed using Stata 17 software. Results Of 1,079 identified studies, 27 eligible included our analysis (N = 3,336 patients). The demonstrated that overall response rate [RR 1.22, 95% CI(1.17, 1.27), Z 9.76, p < 0.01], as well Institutes Health Stroke Scale (NIHSS) score barthel index, significantly better DGMI group compared therapy alone group. However, there was no significant difference observed between experimental control regarding improvements prognosis platelet function. studies reported a total 419 adverse reactions (ADRs), 206 occurring group; furthermore, incidence events two groups. Conclusion Ginkgo preparations, when drugs, can enhance clinical stroke demonstrate favorable profile. combination is potential strategy improve management IS patients has high application value.

Язык: Английский

The efficacy and safety of ginkgo terpene lactone preparations combined with antiplatelet aents in the treatment of ischemic stroke: a systematic review and meta-analysis DOI Creative Commons

Xu Hong,

Li Zeng,

Li Liao

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Март 19, 2025

Background This meta-analysis aimed to assess the efficacy and safety of ginkgo terpene lactone preparations including diterpene ginkgolides meglumine injection (DGMI) ginkgolide combined with antiplatelet drugs in treatment ischemic stroke. Methods We systematically searched randomized controlled trials(RCTs) publication date earlier than 6 November 2024 PubMed, China National Knowledge Infrastructure (CNKI), Chinese Science Technology Journal Database (VIP), Biomedical Literature (CBM), Wanfang Database, Embase, Web Science, ClinicalTrials.gov , Cochrane Library. Studies were screened according inclusion exclusion criteria, evaluated criteria recommended by Handbook, data then analyzed using Stata 17 software. Results Of 1,079 identified studies, 27 eligible included our analysis (N = 3,336 patients). The demonstrated that overall response rate [RR 1.22, 95% CI(1.17, 1.27), Z 9.76, p < 0.01], as well Institutes Health Stroke Scale (NIHSS) score barthel index, significantly better DGMI group compared therapy alone group. However, there was no significant difference observed between experimental control regarding improvements prognosis platelet function. studies reported a total 419 adverse reactions (ADRs), 206 occurring group; furthermore, incidence events two groups. Conclusion Ginkgo preparations, when drugs, can enhance clinical stroke demonstrate favorable profile. combination is potential strategy improve management IS patients has high application value.

Язык: Английский

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