Intermittent fasting and health outcomes: an umbrella review of systematic reviews and meta-analyses of randomised controlled trials

EClinicalMedicine, Год журнала: 2024, Номер 70, С. 102519 - 102519

Опубликована: Март 11, 2024

Benefits of Intermittent fasting (IF) on health-related outcomes have been found in a range randomised controlled trials (RCTs). Our umbrella review aimed to systematically analyze and synthesize the available causal evidence IF its impact specific while evaluating quality.

Язык: Английский

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Meal timing and its role in obesity and associated diseases

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Март 22, 2024

Meal timing emerges as a crucial factor influencing metabolic health that can be explained by the tight interaction between endogenous circadian clock and homeostasis. Mistimed food intake, such delayed or nighttime consumption, leads to desynchronization of internal is associated with an increased risk for obesity disturbances type 2 diabetes cardiovascular diseases. Conversely, meal aligned cellular rhythms optimize performance tissues organs. In this review, we provide overview effects discuss underlying mechanisms. Additionally, explore factors timing, including determinants chronotype genetics, well external influences like social factors, cultural aspects, work schedules. This review could contribute defining meal-timing-based recommendations public initiatives developing guidelines effective lifestyle modifications targeting prevention treatment Furthermore, it sheds light on must considered in design future intervention trials.

Язык: Английский

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Navigating challenges and adherence in time‐restricted eating: A qualitative study

Nutrition & Dietetics, Год журнала: 2025, Номер unknown

Опубликована: Фев. 2, 2025

Abstract Aims Adherence to any dietary approach is crucial for achieving long‐term benefits. This qualitative study aims explore the facilitators and barriers adherence, how individuals in community settings navigate time‐restricted eating their daily lives. Methods Semi‐structured, in‐depth interviews were conducted with 21 participants who had practised (confining window <10h a day; excluding periodic fasting methods like 5:2 or alternate day fasting) periods ranging from 3 months more than 5 years. A content analysis, underpinned by Capability‐Opportunity‐Motivation‐Behaviour Model, identified multiple facilitators, barriers, strategies that evolved over practice. Results Key included simplicity versatility of eating, maintaining non‐obsessive non‐dieting mindset, having supportive environment. Barriers hunger food cravings, an obsessive mindset during initial stages, conflicting schedules social occasions, including holidays. Participants employed several coping successfully adherence reported confidence as lifestyle contributes better health weight management. Conclusion Our findings suggest successful implementation requires flexibility viewing it short‐term loss tool. Guidelines are needed help practitioners implement practices promote healthier behaviours.

Язык: Английский

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Effect of Isocaloric, Time-Restricted Eating on Body Weight in Adults With Obesity

Annals of Internal Medicine, Год журнала: 2024, Номер 177(5), С. 549 - 558

Опубликована: Апрель 19, 2024

Time-restricted eating (TRE) lowers body weight in many studies. Whether TRE induces loss independent of reductions calorie intake, as seen rodent studies, is unknown.

Язык: Английский

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Chrononutrition in the Prevention and Management of Metabolic Disorders: A Literature Review

Nutrients, Год журнала: 2024, Номер 16(5), С. 722 - 722

Опубликована: Март 1, 2024

Background: The concept of time-restricted eating (TRE) or feeding (TRF) promotes daily periods and fasting to determine whole-body physiology. Chronic misalignment circadian rhythms chrono-disruption is related an increased risk diverse metabolic disorders. progression non-communicable diseases seems be affected by the timing meals. As a result, intermittent promising approach for their management. aim present literature review examine scrutinize TRE protocols in fields prevention management Methods: This thorough reported associations among rhythm, disorders, diabetes mellitus, obesity, TRE, TRF, dietary habits, disruption, cardiovascular diseases, atherosclerosis, non-alcoholic fatty liver find already existing clinical studies from last decade (2014–2024) most precise scientific online databases, using relevant specific keywords. Several inclusion exclusion criteria were applied only longitudinal, cross-sectional, descriptive, prospective human studies. Results: currently available findings remain scarce suggest that chrononutrition behaviors such as TRF may promote several benefits, mainly body weight control fat loss. Improvements glucose levels lipid profiles are quite controversial since some show little no effect. far concerned, efficacy stronger disease due decline Conclusions: Even if there has been gradual increase few years, providing perspectives, currently, conclusive evidence role Future should well-designed with longer duration larger sample sizes. Moreover, it important best window its feasibility.

Язык: Английский

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Partially unraveling mechanistic underpinning and weight loss effects of time-restricted eating across diverse adult populations: A systematic review and meta-analyses of prospective studies

PLoS ONE, Год журнала: 2025, Номер 20(1), С. e0314685 - e0314685

Опубликована: Янв. 15, 2025

Time-restricted eating (TRE) is a promising and cost-effective dietary approach for weight management. This study aimed to evaluate the effects of TRE on loss in three adult populations using pre- post-intervention analyses while also investigating its underlying mechanism. A systematic search was conducted across four databases (PubMed, Web Science, Scopus, CENTRAL) up until January 28, 2024, specifically focusing prospective studies that examined efficacy achieving loss. random model employed conduct meta-analyses, heterogeneity assessed I 2 statistic (PROSPERO: CRD42023439317). The encompassed 36 selected involving 44 effect sizes 914 participants. effectiveness found vary health conditions, with modest observed healthy individuals (pooled size -1.04 Kg, 95% CI: -1.42 -0.65) more significant reduction seen participants chronic diseases -3.33 -5.05 -1.62) overweight/obesity -4.21 -5.23 -3.10). decrease body could be partially attributed factors influencing energy balance, as evidenced by significantly lower mean calorie intake at end intervention (1694.71 kcal/day, 1498.57–1890.85) compared baseline (2000.64 1830–2172.98), despite absence intentional efforts restrict These findings support this lifestyle maintenance guide development clinical guidelines.

Язык: Английский

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Meal Timing and Anthropometric and Metabolic Outcomes

JAMA Network Open, Год журнала: 2024, Номер 7(11), С. e2442163 - e2442163

Опубликована: Ноя. 1, 2024

Meal timing strategies, such as time-restricted eating (TRE), reducing meal frequency, or altering calorie distribution across the day, have gained interest for their potential to enhance weight loss and metabolic health, particularly in managing chronic diseases, yet long-term benefits are not known.

Язык: Английский

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Intermittent fasting as a treatment for obesity in young people: a scoping review

npj Metabolic Health and Disease, Год журнала: 2024, Номер 2(1)

Опубликована: Дек. 30, 2024

Intermittent fasting focuses on the timing of eating rather than diet quality or energy intake, with evidence supporting its effects weight loss and improvements in cardiometabolic outcomes adults obesity. However, there is limited for feasibility efficacy young people. To address this, a scoping review was conducted to examine intermittent regimens individuals aged 10 25 treatment obesity focusing methodology, intervention parameters, outcomes, adherence, feasibility, efficacy. Due paucity this age group, adequately assess all published studies category, regardless status intention, were included review. The 34 (28 interventional 6 observational studies) 893 participants 12 25. Interventions varied 9 cohorts utilizing as an treatment. Thirteen utilized 8-h time-restricted eating. Primary risk factors (7/28), anthropometric measurements body composition (5/28), muscular performance (4/28), (1/28), others (4/28). All people reported some degree loss, although comparator groups significantly. This underscores various utilizations group highlights potential treating findings emphasize need rigorous standardized frameworks ensure comparability determine fasting's practicality depending outcome interest.

Язык: Английский

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The Ketone Bridge Between the Heart and the Bladder: How Fast Should We Go?

International Neurourology Journal, Год журнала: 2024, Номер 28(Suppl 1), С. 2 - 11

Опубликована: Фев. 27, 2024

Metabolic syndrome (MS) is associated with both cardiovascular and bladder dysfunction. Insulin resistance (IR) central obesity, in particular, are the main risk factors. In these patients, vicious pathological cycles exacerbate abnormal carbohydrate metabolism sustain an inflammatory state, serious implications for heart bladder. Ketone bodies serve as alternative energy source this context. They considered a "super-fuel" because they generate adenosine triphosphate less oxygen consumption per molecule, thus enhancing metabolic efficiency. have positive impact on all components of MS. aid weight loss glycemic control, lower blood pressure, improve lipid profiles, enhance endothelial function. Additionally, possess direct anti-inflammatory, antioxidant, vasodilatory properties. A shared key player dysfunction formation NLRP3 inflammasome, which ketone inhibit. Interventions that elevate body levels-such fasting, ketogenic diet, supplements, sodium-glucose cotransporter 2 inhibitors-have been shown to directly affect outcomes urinary tract symptoms derived from This review explores pathophysiological basis benefits cardiac

Язык: Английский

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Effect of Early Time-Restricted Eating on Metabolic Markers and Body Composition in Individuals with Overweight or Obesity

Nutrients, Год журнала: 2024, Номер 16(14), С. 2187 - 2187

Опубликована: Июль 9, 2024

This study aimed to evaluate the effect of early time-restricted eating (eTRE) on metabolic markers and body composition in individuals with overweight or obesity. Seventeen subjects completed a randomized, crossover, controlled clinical trial. Twelve women five men participated, mean age 25.8 ± 10.0 years BMI 32.0 6.3 kg/m2. The eTRE intervention included 16 h fasting (3:00 pm 7:00 am) 8 ad libitum (7:00 am 03:00 pm) (16:8). trial four weeks interventions followed by four-week washout period. Body weight, waist hip circumferences, measurements were taken. Additionally, venous blood sample was collected for biochemical determinations. In before–after analysis, induced reduction BW but this not significant when compared control group. did modify any other anthropometric measurements, parameters, glycemic insulinemic responses, pressure, subjective appetite. conclusion, induce beneficial effects lipid metabolisms, composition, appetite, pressure. These findings may be attributed special characteristics population short

Язык: Английский

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