Analysis of laboratory indicators of inflammation, infection and indicators of subclinical atherosclerosis in patients with systemic lupus erythematosus and myocardial infarction

Clinical Medicine (Russian Journal), Год журнала: 2024, Номер 102(7), С. 542 - 549

Опубликована: Ноя. 21, 2024

Objective of the study: to investigate correlation between inflammation activity, infectious components, platelet function, dyslipidemia, and development subclinical atherosclerosis in patients with systemic lupus erythematosus (SLE) ischemic heart disease. Materials methods. The study involved measurement C-reactive protein (CRP), interleukin 6, IgG antibodies Chlamydia pneumonia, toll-like receptors (TLR2), factor 4 (PF4), aggregation parameters, lipid profile, concentration oxidized low-density lipoproteins (oxLDL), thickness intima-media complex (IMT) common carotid arteries. Results. included 50 women SLE 31 myocardial infarction (MI), a control group 21 healthy women. Patients showed significant increase IMT artery (1.00 [0.80–1.10] > 0.80 [0.70–0.90], p = 0.01) bifurcation (1.10 [1.00–1.20] [0.70–1.10], compared group. Similarly, MI had significantly different values for both (0.90 (1.20 [1.10–1.40] controls. There was pronounced activation patients, evidenced by increased levels CRP (3.67 [2.17–5.92] 0.74 [0.30–1.26], 0.01), 6 (1.72 [1.39–2.68] 0.60 [0.22–0.75], ESR (21.0 [18.0–26.0] 10.0 [7.0–14.0], 0.01). These markers were also elevated controls: (3.36 [1.44–5.90] (1.1 [0.69–1.82] (19.0 [10.0–28.0] A platelets noted, marked PF4 (21.5 [19.80–23.28] 18.30 [13.88–20.46], (20.76 [19.00–23.50] exhibited characterized oxLDL (3.16 [1.45–4.60] 1.39 [1.26–2,04], 0,01). In contrast, differences only (1.05 [0.88–1.21] < 1.32 [1.24–1.37], pneumonia (0,062 [0,035-0,124] 0,0415 [0,022-0,071], 0,11) TLR2 no diferences from controls (635,71 [357,14 –978,5] 451,54 [352,05–775,0], 0,39). did not differ (448,98 [308,67–964,14] 0,854). However, higher (0,067 [0,05–0,11] [0,022–0,071], 0,026) Conclusion. addition traditional risk factors cardiovascular diseases, those exhibit mechanisms autoinflammation as form inflammatory component more group, particularly reflected concentrations IL-6 levels. role requires further investigation.

Язык: Английский

---

The main pro- and antiinflammatory cytokines in rheumatoid arthritis: interrelationships and pathogenetic significance

Medical alphabet, Год журнала: 2024, Номер 29, С. 68 - 74

Опубликована: Дек. 12, 2024

Imbalance in the production of pro- and anti-inflammatory cytokines plays an important role pathogenesis rheumatoid arthritis (RA). The aim study. To determine concentration frequency increase serum patients with RA advanced stage disease, assessment relationship between them, clinical laboratory activity disease autoantibodies. Materials methods. We examined 154 (41 men 113) women, average age (56.0 [50.0; 64.0] years), duration (9.4 [3.0; 13.0] seropositive 129 (83.8 %) for IgM factor (RF) and/or 106 (68.8 antibodies to cyclic citrullinated peptides (ACCP) moderate high (DAS 28-ESR – 5.40 [4.65; 6.00]) activity. interleukin (IL), tumor necrosis α (TNF-α), interferon-γ (INF-γ), soluble CD 40 ligand (sCD 40L) was determined by multiplex technology. Results. In patients, IL-6, IL-23, IL-31, IL-33 INF-γ significantly higher, TNF-α values were lower than controls. levels IL-1β, IL-17A, IL-17F, IL-25 sCD 40L not different from donors. IL-10 higher donors, IL-4 RA, elevation 87.0 %, IL-6 51.6 IL-31 48.1 IL-17F 46.1 IL-23 42.9 % 39.0 IL-17A 29.9 IL-1β 26.6 23.4 11.7 3.2 patients. hyperproduction predominant over other (p < 0.001). Elevated found 16.2 12.3 Hyperproduction proinflammatory cytokines, except 40L, prevailed IL-10. Correlations among themselves found. High associated only IL-31. concentrations correlated each other. be DAS 28-ESR, CDAI SDAI; IL-10, IL-33, CRP; INF-γ, RF ACCP; RF. IL10 positively RF, negatively ADCP. Conclusions. there is imbalance a predominance production. Despite presence interrelationships are significant differences them associations indices, indicators

Язык: Английский

---

Colchicine: Repositioning an “ancient” medicine in the 21st century

Rheumatology Science and Practice, Год журнала: 2024, Номер 62(5), С. 445 - 464

Опубликована: Окт. 31, 2024

The main indications for colchicine treatment until recently were gout, pericarditis, familial Mediterranean fever and some other auto-inflammatory diseases. expansion of (repositioning) the use in direction prevention cardiovascular complications should be considered as one major events medicine XXI century. Deciphering role inflammation most important mechanism development atherosclerosis has created prerequisites concept anti-inflammatory therapy atherosclerosis, which low-dose can take an place, complementing effects aspirin, statins antihypertensive therapy. analysis materials from randomized placebo-controlled studies indicates a decrease frequency patients with coronary heart disease (by 31%) who have suffered myocardial infarction 23%), well 33%), stroke, need revascularization mortality. low dose (0.5 mg/day) is approved by U.S. Food Drug Administration disease. It assumed that future will place pathology associated atherosclerotic vascular

Язык: Английский

---

Mechanisms of Regulation Allergic and Autoimmune Reactions by Bacterial Origin Bioregulators

RUDN Journal of Medicine, Год журнала: 2023, Номер 27(4), С. 470 - 482

Опубликована: Дек. 15, 2023

Relevance. The increase in allergic and autoimmune diseases observed recent decades highlights the need for therapy prevention, which requires detailed research into mechanisms of their occurrence. onset progression are influenced by genetic predisposition, lifestyle, environmental factors, disruptions coordinated operation immune system, as a consequence homeostasis. Treatment these is primarily symptomatic often accompanied undesirable side effects. Immune system disorders various pathologies have own characteristics each type disease, at same time common mechanisms. Considering presence large number microorganisms human body, taking influence account paramount importance. Microorganisms source biologically active molecules, action can either prevent reduce severity disease or exacerbate it. aim this study was to analyze cytokine profile effects fragments cell walls Gram-negative Gram-positive bacteria - lipopolysaccharide (LPS) muramyl peptide (MP), well nisin an antimicrobial bacterial origin on mononuclear cells. Materials Methods. Mononuclear cells were obtained from peripheral blood healthy volunteers using Cell separation media Lympholyte CL 5015, cultured LPS, GMDP bacteriocin nisin. activity examined multiplex analysis; analysis surface markers determined flow cytometry. Results Discussion. It shown that wall much greater extent than induce production cytokines, chemokines, growth factors. established LPS MP expression CD11c dendritic cells, while does not affect CD11c+ DCs. conducted ex vivo studies did emergence CCR7. Conclusion. Bacterial bioregulators trigger negative feedback mechanism inducing synthesis anti-inflammatory inflammatory process. Understanding molecular body opens new approaches prevention development personalized strategies.

Язык: Английский

---

DMOADs and DMARDs in the treatment of patients with joint and spine diseases

FARMAKOEKONOMIKA Modern Pharmacoeconomics and Pharmacoepidemiology, Год журнала: 2023, Номер 16(4), С. 700 - 707

Опубликована: Дек. 12, 2023

The data on the classification of drugs, which are prescribed for treatment patients with joint and spine diseases, such as osteoarthritis (OA) rheumatoid arthritis (RA), presented. groups drugs widely used in clinical practice disease-modifying (DMOADs) antirheumatic (DMARDs). To help practitioner, consolidated information is provided main differences between these according to mechanism action (immunomodulatory vs. immunosuppressive) indications use (autoinflammatory diseases autoimmune (RA, psoriatic arthritis, ankylosing spondyloarthritis)). material article focused clinicians them make a right choice OA therapy, identify problem drug RA. Information about possibility using nutritional support

Язык: Английский

---

Autoimmunity in rheumatology: A review

Terapevticheskii arkhiv, Год журнала: 2023, Номер 95(12), С. 1056 - 1063

Опубликована: Дек. 28, 2023

Autoimmunity and autoinflammation, co-potentiating pathological processes, are considered within the "immune-inflammatory" continuum (continuity with a variety of elements), reflecting close relationship between innate acquired immune responses. is leading pathogenetic mechanism for specific type human chronic inflammatory disorders – autoimmune diseases, affecting more than 10% people in general population. Advances molecular biology, pharmacogenetics, bioinformatics provided background individualizing therapy systemic rheumatic diseases personalized medicine. Studying immunopathogenesis mechanisms, improving diagnostics, interpreting taxonomy, developing approaches to prevention priority issues modern

Язык: Английский

---