Dysregulation of the Immune System in Advanced Periimplantitis: Systemic Implications and Inflammatory Mechanisms—A Hematological and Immunological Study
Journal of Clinical Medicine,
Год журнала:
2025,
Номер
14(7), С. 2453 - 2453
Опубликована: Апрель 3, 2025
Objectives:
This
study
aimed
to
assess
the
systemic
and
local
inflammatory
responses
in
patients
with
periimplantitis,
focusing
on
key
immune
markers
clinical
parameters.
The
further
explores
relationship
between
markers,
indices,
dysregulation,
particularly
regarding
T-cell
exhaustion
inflammation.
Methods:
A
cohort
of
classified
into
moderate
advanced
stages,
was
compared
a
control
group
healthy
individuals
dental
implants.
Clinical
parameters,
including
plaque
index
(API),
bleeding
probing
(BoP),
pocket
depth
(PPD),
peri-implant
sulcus
(PSI),
were
recorded.
Hematological,
immunological,
biochemical
analyses
performed,
focus
cell
populations
(NK
cells,
T-cells,
their
PD-1
PD-L1).
Results:
Patients
periimplantitis
exhibited
significantly
higher
indices
(API,
BoP,
PSI,
PPD)
than
group,
most
pronounced
differences
group.
Hematological
analysis
revealed
increased
leukocyte
neutrophil
counts,
whereas
NK
levels
reduced.
Immunological
profiling
indicated
elevated
PD-L1
expression
suggesting
dysregulation.
Furthermore,
strong
correlations
found
PPD
values
marker
levels,
highlighting
Conclusions:
findings
confirm
that
dysregulation
plays
central
role
progression.
association
alterations,
emphasizes
need
for
multifactorial
diagnostic
treatment
approach.
Integrating
modulation
strategies,
assessments,
lifestyle
modifications,
such
as
improved
oral
hygiene
smoking
cessation,
could
improve
disease
management
reduce
recurrence.
Язык: Английский
Current understanding of the etiology, diagnosis, treatment, and management of peri-implant diseases: a narrative review for the consensus report of the Korean Academy of Periodontology
Journal of Periodontal & Implant Science,
Год журнала:
2024,
Номер
54(6), С. 377 - 377
Опубликована: Янв. 1, 2024
Over
the
past
few
decades,
dental
implants
have
been
successfully
utilized
to
replace
teeth
lost
due
periodontal
disease
and
other
conditions.
However,
similar
natural
teeth,
are
vulnerable
inflammatory
peri-implant
diseases,
which
can
compromise
their
long-term
viability.
This
review
aims
summarize
current
understanding
of
diseases
discuss
effective
strategies
for
diagnosis,
treatment,
management.
Evidence
related
was
categorized
reviewed
in
4
sections:
1)
definition,
prevalence,
classification;
2)
risk
indicators
etiological
factors;
3)
diagnostic
criteria;
4)
treatment
protocols
diseases.
The
prevalence
mucositis
peri-implantitis
is
significant,
affecting
43%
22%
implant
cases,
respectively.
Key
factors
include
poor
oral
hygiene,
a
history
periodontitis,
systemic
conditions
such
as
diabetes
smoking.
outcomes
influenced
by
design
prosthesis
condition
surrounding
soft
tissue.
Management
include:
non-surgical
diagnosed
with
mucositis;
comprehensive
involves
both
mechanical
chemical
debridement
surgical
access,
affected
peri-implantitis;
removal
failed
implants,
followed
restoration
pre-existing
bone
defects.
Managing
necessitates
approach,
encompassing
assessment,
tailored
planning,
stringent
maintenance
protocols.
Regular
follow-ups
patient
education
critical
preventing
recurrence
ensure
success
therapy.
Язык: Английский
Correlation between newly formed bone and the progression of experimental peri-implantitis with or without alveolar ridge preservation in infected and non-infected teeth: a secondary analysis of a preclinical study
Journal of Periodontal & Implant Science,
Год журнала:
2024,
Номер
55(2), С. 139 - 139
Опубликована: Ноя. 19, 2024
We
examined
the
progression
of
experimental
peri-implantitis
in
sites
that
underwent
either
alveolar
ridge
preservation
(ARP)
or
spontaneous
healing
(SH),
comparing
infected
teeth
(IT)
and
non-infected
(NIT).
This
investigation
is
a
secondary
analysis
preclinical
study
aimed
at
exploring
correlation
between
newly
formed
bone
implant
stability
quotient
(ISQ),
as
well
association
peri-implantitis.
The
bilateral
mandibular
third
fourth
premolars
6
beagle
dogs
were
randomly
assigned
to
4
groups:
IT/SH,
IT/ARP,
NIT/SH,
NIT/ARP.
Following
placement,
core
biopsies
retrieved
from
each
site,
ISQ
value
was
measured.
A
3-month
period
allowed
for
induction,
followed
by
an
additional
3
months
peri-implantitis,
with
radiographs
taken
time
point.
During
no
statistically
significant
differences
observed
among
groups
terms
mean
values
radiographic
marginal
loss.
Similarly,
percentages
substitute,
bone,
fibrovascular
connective
tissue
did
not
differ
significantly
groups.
Linear
regression
revealed
linear
any
group
(P>0.05).
However,
weak
loss
during
noted
IT/SH
alone
(P=0.036).
Within
limitations
this
study,
we
unable
demonstrate
ARP
could
improve
primary
stability.
Furthermore,
neither
nor
SH
influenced
Язык: Английский