Science Translational Medicine,
Год журнала:
2023,
Номер
15(700)
Опубликована: Июнь 14, 2023
Alzheimer’s
disease
(AD)
pathology
is
thought
to
progress
from
normal
cognition
through
preclinical
and
ultimately
symptomatic
AD
with
cognitive
impairment.
Recent
work
suggests
that
the
gut
microbiome
of
patients
has
an
altered
taxonomic
composition
compared
healthy,
cognitively
control
individuals.
However,
knowledge
about
changes
in
before
onset
limited.
In
this
cross-sectional
study
accounted
for
clinical
covariates
dietary
intake,
we
microbial
function
a
cohort
164
individuals,
49
whom
showed
biomarker
evidence
early
AD.
Gut
profiles
individuals
were
distinct
those
without
The
change
correlated
β-amyloid
(Aβ)
tau
pathological
biomarkers
but
not
neurodegeneration,
suggesting
may
process.
We
identified
specific
bacterial
taxa
associated
Inclusion
these
features
improved
accuracy,
sensitivity,
specificity
machine
learning
classifiers
predicting
status
when
tested
on
subset
(65
participants).
correlates
neuropathology
improve
our
understanding
etiology
help
identify
gut-derived
markers
risk.
Nutrients,
Год журнала:
2022,
Номер
14(3), С. 668 - 668
Опубликована: Фев. 5, 2022
Gut
microbiota
is
emerging
as
a
key
regulator
of
many
disease
conditions
and
its
dysregulation
implicated
in
the
pathogenesis
several
gastrointestinal
extraintestinal
disorders.
More
recently,
gut
microbiome
alterations
have
been
linked
to
neurodegeneration
through
increasingly
defined
brain
axis,
opening
possibility
for
new
microbiota-based
therapeutic
options.
Although
studies
conducted
unravel
possible
relationship
between
Alzheimer’s
Disease
(AD)
progression,
diagnostic
potential
approaches
aiming
at
restoring
eubiosis
remain
be
fully
addressed.
In
this
narrative
review,
we
briefly
summarize
role
homeostasis
health
disease,
present
evidence
AD
patients.
Based
on
these
observations,
then
discuss
how
dysbiosis
might
exploited
tool
early
advanced
stages,
examine
prebiotics,
probiotics,
fecal
transplantation,
diets
complementary
interventions
thus
offering
insights
into
diagnosis
treatment
devastating
progressive
disease.
Oxidative Medicine and Cellular Longevity,
Год журнала:
2020,
Номер
2020, С. 1 - 14
Опубликована: Янв. 13, 2020
Alzheimer's
disease
(AD)
is
the
most
common
cause
of
dementia
in
elderly
patients.
Recently,
several
studies
have
shown
that
inflammation
and
oxidative
stress
precede
cardinal
neuropathological
manifestations
AD.
In
view
proven
antioxidant
effects
probiotics,
we
proposed
continuous
dietary
supplementation
with
milk
fermented
kefir
grains
might
improve
cognitive
metabolic
and/or
cellular
disorders
AD
This
study
was
designed
as
an
uncontrolled
clinical
investigation
to
test
probiotic-fermented
(2
mL/kg/daily)
for
90
days
patients
exhibiting
deficit.
Cognitive
assessment,
cytokine
expression,
systemic
levels,
blood
cell
damage
biomarkers
were
evaluated
before
(T0)
after
(T90)
synbiotic
supplementation.
When
challenged
solve
8
classical
tests,
majority
exhibit
a
marked
improvement
memory,
visual-spatial/abstraction
abilities,
executive/language
functions.
At
end
treatment,
cytometric
analysis
showed
absolute/relative
decrease
markers
(·O2
-,
H2O2,
ONOO-,
~30%)
accompanied
by
increase
NO
bioavailability
(100%).
agreement
above
findings
using
same
technique,
observed
similar
magnitude
serum
protein
oxidation,
mitochondrial
dysfunction,
DNA
damage/repair,
apoptosis.
conclusion,
demonstrated
improves
deficits,
which
seems
be
linked
three
important
factors
AD-systemic
inflammation,
stress,
damage-and
may
promising
adjuvant
therapy
against
progression.
BMB Reports,
Год журнала:
2020,
Номер
53(1), С. 10 - 19
Опубликована: Янв. 31, 2020
Other
SectionsABSTRACTINTRODUCTIONPRO-INFLAMMATORY
CYTOKINES
IN
ADANTI-INFLAMMATORY
ADTHE
ROLE
OF
INTESTINAL
(BRAIN-GUT
AXIS)
ADPOTENTIAL
USE
BLOOD
IMMUNE
CELLS
AS
BIOMARKERS
FOR
ADCOMPLEMENTS
ADCONCLUSIONACKNOWLEDGEMENTSCONFLICTS
INTERESTFIGURETABLEREFERENCES
Science Translational Medicine,
Год журнала:
2023,
Номер
15(700)
Опубликована: Июнь 14, 2023
Alzheimer’s
disease
(AD)
pathology
is
thought
to
progress
from
normal
cognition
through
preclinical
and
ultimately
symptomatic
AD
with
cognitive
impairment.
Recent
work
suggests
that
the
gut
microbiome
of
patients
has
an
altered
taxonomic
composition
compared
healthy,
cognitively
control
individuals.
However,
knowledge
about
changes
in
before
onset
limited.
In
this
cross-sectional
study
accounted
for
clinical
covariates
dietary
intake,
we
microbial
function
a
cohort
164
individuals,
49
whom
showed
biomarker
evidence
early
AD.
Gut
profiles
individuals
were
distinct
those
without
The
change
correlated
β-amyloid
(Aβ)
tau
pathological
biomarkers
but
not
neurodegeneration,
suggesting
may
process.
We
identified
specific
bacterial
taxa
associated
Inclusion
these
features
improved
accuracy,
sensitivity,
specificity
machine
learning
classifiers
predicting
status
when
tested
on
subset
(65
participants).
correlates
neuropathology
improve
our
understanding
etiology
help
identify
gut-derived
markers
risk.
