CASPASE-3 ACTIVITY IN CARDIAC TISSUE UNDER LONG-TERM RELEASING HORMONE BLOCKADE AND QUERCETIN ADMINISTRATION IN MALE RATS DOI Open Access

T. A. Voroshilova,

V. I. Shepitko,

E.V. Stetsuk

и другие.

Актуальні проблеми сучасної медицини Вісник Української медичної стоматологічної академії, Год журнала: 2024, Номер 24(4), С. 194 - 200

Опубликована: Дек. 26, 2024

Introduction. Caspase-3 is a key enzyme in apoptosis, though its exact role programmed cell death remains incompletely understood. Studies have demonstrated that caspase-3 plays critical specific types or under particular stimuli, as well initiating and completing biochemical processes associated with apoptosis. Men congestive heart failure often exhibit reduced testosterone levels, research suggests therapy can improve cardiac output lower peripheral vascular resistance. However, effects on function, cardiomyocyte ventricular remodeling remain unclear. The aim of this study was to examine the impact suppression activity tissues during long-term releasing hormone blockade male rats treated quercetin. Materials methods. conducted 60 sexually mature rats. animals were randomly divided into two groups: control (n=10) experimental (n=50). In order modulate central deprivation luteinising synthesis, group received solution tryptorelin at dose 0.3 mg active ingredient per kg body weight quercetin 100 mg/kg 3 times week. Results. Immunohistochemical analysis showed caspase increased sharply maximum 30th day observation after administration tryptorelin, followed by gradual significant decrease indicator 180th 365th days p˂0.05. When administered, shown Fig. 2, main pattern (a sharp increase 30 then decline until 365) preserved, but reliability quantitative parameter only 90 study. Conclusions. addition diet leads immunoreactivity cells expression, which be regarded compensatory phenomenon aimed balancing apoptosis conditions hormonal dysfunction suppressing synthesis.

Язык: Английский

CASPASE-3 ACTIVITY IN CARDIAC TISSUE UNDER LONG-TERM RELEASING HORMONE BLOCKADE AND QUERCETIN ADMINISTRATION IN MALE RATS DOI Open Access

T. A. Voroshilova,

V. I. Shepitko,

E.V. Stetsuk

и другие.

Актуальні проблеми сучасної медицини Вісник Української медичної стоматологічної академії, Год журнала: 2024, Номер 24(4), С. 194 - 200

Опубликована: Дек. 26, 2024

Introduction. Caspase-3 is a key enzyme in apoptosis, though its exact role programmed cell death remains incompletely understood. Studies have demonstrated that caspase-3 plays critical specific types or under particular stimuli, as well initiating and completing biochemical processes associated with apoptosis. Men congestive heart failure often exhibit reduced testosterone levels, research suggests therapy can improve cardiac output lower peripheral vascular resistance. However, effects on function, cardiomyocyte ventricular remodeling remain unclear. The aim of this study was to examine the impact suppression activity tissues during long-term releasing hormone blockade male rats treated quercetin. Materials methods. conducted 60 sexually mature rats. animals were randomly divided into two groups: control (n=10) experimental (n=50). In order modulate central deprivation luteinising synthesis, group received solution tryptorelin at dose 0.3 mg active ingredient per kg body weight quercetin 100 mg/kg 3 times week. Results. Immunohistochemical analysis showed caspase increased sharply maximum 30th day observation after administration tryptorelin, followed by gradual significant decrease indicator 180th 365th days p˂0.05. When administered, shown Fig. 2, main pattern (a sharp increase 30 then decline until 365) preserved, but reliability quantitative parameter only 90 study. Conclusions. addition diet leads immunoreactivity cells expression, which be regarded compensatory phenomenon aimed balancing apoptosis conditions hormonal dysfunction suppressing synthesis.

Язык: Английский

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