Clinical characteristics and prognosis of COVID-19- associated invasive pulmonary aspergillosis in critically patients: a single-center study
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2025,
Номер
15
Опубликована: Апрель 22, 2025
A
single-center
retrospective
study
was
conducted
according
to
the
latest
diagnostic
criteria
of
European
Consortium
for
Mycology
in
Medicine/International
Society
Human
and
Animal
Mycoses
(ECMM/ISHAM)
Consensus,
which
describes
clinical
characteristics,
factors
influencing
prognosis
a
group
patients
with
COVID-19
(Omicron
variant)
combined
invasive
pulmonary
mycoses
onset
disease
at
end
2022.
This
retrospectively
analyzed
data
related
58
hospitalized
severe
pneumonia
due
infection
admitted
ICU
critical
care
medicine,
respiratory
ICU,
Department
Infections
First
Affiliated
Hospital
Soochow
University
from
December
1,
2022,
January
31,
2023.
CAPA
defined
ECMM/ISHAM
consensus
criteria.
Our
compared
microbiological
characteristics
associated
risk
fungal
infections
performed
univariate
multivariate
analyses
mortality
COVID-19-Associated
Pulmonary
Aspergillosis
(CAPA).
17
(29.3%)
critically
ill
were
diagnosed
CAPA,
10
(58.82%)
Probable
7
(41.18%)
Possible
CAPA.
Among
this
Aspergillus
strains,
fumigatus
strains
found
13
cases
(76.47%)
niger
4
(23.53%).
had
concomitant
bacterial
rate
57.14%
(4/7),
Acinetobacter
baumannii
most
common
pathogen.
galactomannan
assay
bronchoalveolar
lavage
fluid
(BALF)
5
100%
(5/5)
positivity
rate,
two
or
more
serum
(GM)
assays
patients,
probability
favorable
results
both
41.2%
(7/17).
The
60-day
52.9%
(9/17),
whereas
non-CAPA
24.4%
(10/41),
statistically
different
(P
=
0.035).
Diabetes
mellitus
0.018,
OR:
5.040
(95%
CI:
1.314-19.337)),
renal
insufficiency
(P=0.002,
11.259
2.480-51.111)),
chronic
obstructive
(COPD)
0.003,
6.939
1.963-24.531)),
elevated
interleukin-6
(IL-6)
0.022,
4.160
1.226~14.113)),
mechanical
ventilation
0.002,
8.100
(95%CI:
2.132~30.777)),
increased
duration
steroids
use
1.071
1.010~1.135)),
cumulative
dose
((P
<
0.001,
1.012
1.009~1.015)),
tocilizumab
0.020,
11.480
2.480~51.111)),
length
hospitalization
0.021,
1.038
1.006
1.071)),
increase
type
antibiotics
used
1.603
1.181
2.176))
occurrence
infections,
not,
baricitinib
hypertension
did
not
have
significant
effect
on
>
0.05).
Patients
higher
their
prolonged
patients.
all-cause
52.9%.
We
also
potential
mortality,
including
0.040
10.500,
1.115
98.914)),
advanced
age
0.043
1.212,
1.460)),
significantly
CRP
level
0.042
1.043,
1.002~1.078))
worse
prognosis.
Steroids
use,
gender,
diabetes
patient
death
Язык: Английский
Impact of COVID-19 on mortality in out-of-hospital cardiac arrest patients with return of spontaneous circulation: a retrospective cohort study
Scandinavian Journal of Trauma Resuscitation and Emergency Medicine,
Год журнала:
2025,
Номер
33(1)
Опубликована: Май 1, 2025
Язык: Английский
Prevalence and risk factors associated with multidrug-resistant bacteria in COVID-19 patients
Medicine,
Год журнала:
2024,
Номер
103(10), С. e37389 - e37389
Опубликована: Март 8, 2024
Bacterial
coinfection
among
patients
with
confirmed
coronavirus
disease
2019
(COVID-19)
is
a
critical
medical
concern
that
increases
the
severity
and
mortality
rate.
The
current
study
aimed
at
evaluating
effects
of
bacterial
coinfections
COVID-19
patients,
especially
in
relation
to
degree
mortality.
A
retrospective
was
conducted
for
positive
test,
admitted
regional
hospital
Jeddah,
Saudi
Arabia,
between
May
August
2020.
specimen
(e.g.,
blood,
urine,
or
sputum)
collected
from
COVID-19,
cultured
determine
caused
by
multidrug
resistant
(MDR)
bacteria.
were
categorized
into
2
groups
based
on
result
culture,
as
without
coinfection.
Independent
sample
t
test
Mann–Whitney
U
used
compare
age
hospitalization
period
these
groups.
In
addition,
binominal
logistic
regression
applied
identify
risk
factors
associated
included
342
laboratory
COVID-19.
Eighty
(23.3%)
diagnosed
coinfection,
while
remaining
262
(76.6%)
did
not
Length
stay
prolonged
(16.01
±
11.36
days)
when
compared
(6.5
6.12
days).
Likewise,
rate
significantly
higher
(90%)
those
(49.2%).
Gram-negative
bacteria
predominant
gram-positive,
Klebsiella
pneumoniae
(35
[43.8%])
Acinetobacter
baumanni
(32
[40%]).
On
other
hand,
Staphylococcus
aureus
(4
[5%]),
Enterococcus
faecalis
(1
[1.3%]),
faecium
[1.3%])
identified
gram-positive
species
recruited
patients.
findings
showed
prolong
main
factor
death.
Thus,
health
care
providers
should
minimize
well
following
continuous
monitoring
control
spread
infection
reducing
Язык: Английский