Resveratrol, Piceatannol, Curcumin, and Quercetin as Therapeutic Targets in Gastric Cancer—Mechanisms and Clinical Implications for Natural Products DOI Creative Commons
Paulina Warias,

Paulina Plewa,

Agata Poniewierska-Baran

и другие.

Molecules, Год журнала: 2024, Номер 30(1), С. 3 - 3

Опубликована: Дек. 24, 2024

Gastric cancer remains a significant global health challenge, driving the need for innovative therapeutic approaches. Natural polyphenolic compounds such as resveratrol, piceatannol, curcumin, and quercetin currently show promising results in prevention treatment of various cancers, due to their diverse biological activities. This review presents effects natural on important processes related cancer, apoptosis, proliferation, migration, invasion, angiogenesis, autophagy. Resveratrol, naturally found red grapes, has been shown induce apoptosis inhibit invasion gastric cells. Piceatannol, metabolite shares similar anticancer properties, particularly modulating Curcumin, derived from turmeric, is known its anti-inflammatory antioxidant ability tumor growth metastasis. Quercetin, flavonoid fruits vegetables, induces cell cycle arrest while enhancing efficacy conventional therapies. Despite potential, challenges low bioavailability limit clinical application, necessitating further research into novel delivery systems. Collectively, these represent avenue improving patient outcomes through multifaceted effects.

Язык: Английский

Jian Pi Hua Tan Fang Reverses Trastuzumab Resistance of HER2‐Positive Gastric Cancer Through PI3K/AKT/mTOR Pathway: Integrating Network Pharmacology, Molecular Docking and Experimental Validation DOI Creative Commons
Jia Hu,

Wenjing Bu,

Yongfang Ding

и другие.

Immunity Inflammation and Disease, Год журнала: 2025, Номер 13(2)

Опубликована: Фев. 1, 2025

ABSTRACT Background Currently, trastuzumab resistance significantly impacts the treatment outcome for individuals with HER2‐positive gastric cancer. In clinical practice, Jian Pi Hua Tan Fang (JPHTF) has been shown to be effective in preventing recurrences and metastases caused by Yet, process remains unknown. We aim evaluate potential pharmacological mechanism of JPHTF interfering cancer (GC). Methods this study, network pharmacology molecular docking techniques were used forecast active ingredients, pathways, targets overcoming GC. Then, vitro models NCI‐N87/TR was developed, JPHTF‐containing serum utilized intervention confirm these crucial targets. Results Network showed that 92 compounds 420 therapeutic JPHTF. SRC, EGFR, TP53, AKT1 identified as main associated PI3K/Akt, MAPK, Ras playing roles angiogenesis, cell apoptosis, proliferation, chemotherapy GC microenvironment. Molecular analysis quercetin, formononetin, luteolin, which are exhibit high binding affinity central PI3K, AKT, mTOR. experiment, a significant alleviating effect on reversing apoptotic proliferation NCI‐N87/TR. Further biological experiments could regulate expression PI3K/AKT/mTOR pathway. Conclusion ability overcome NCI‐N87 cells through regulation

Язык: Английский

Процитировано

1
Mechanism of Curcumin in the Treatment of Intrauterine Adhesions Based on Network Pharmacology, Molecular docking, and Experimental Validation DOI
Qiaoxia Li,

Yongyan Zhang,

Hao-Yu Shen

и другие.

Biochemical Genetics, Год журнала: 2025, Номер unknown

Опубликована: Фев. 13, 2025

Язык: Английский

Процитировано

1
Beclin-1: a therapeutic target at the intersection of autophagy, immunotherapy, and cancer treatment DOI Creative Commons
Zhijun Cao,

Ke Tian,

Yincheng Ran

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Ноя. 22, 2024

The significant identification of Beclin-1’s function in regulating autophagy flow signified a progression our understanding cellular operations. Beclin-1 acts as scaffold for forming the PI3KC3 complex, controlling and trafficking processes complicated way. This intricate protein has garnered considerable attention due to its substantial impact on development tumors. Strong evidence indicates plays critical role various human cancer types connection with apoptosis ferroptosis. potential viable target therapy is highlighted by associations key regulators such AMPK, mTOR, ATGs. controls growth dissemination tumors autophagy. It also affects how react therapies chemotherapy radiation therapy. can influence apoptosis, depending whether it supports cell survival or leads death. crucial ferroptosis increasing ATG5 levels, which turn promotes autophagy-triggered Finally, we analyzed possible tumor immunology drug sensitivity cancers. In general, autophagy, offering potentials medical intervention altering biology.

Язык: Английский

Процитировано

5
Potential mechanism of traditional Chinese medicine intervention in gastric cancer: targeted regulation of autophagy DOI Creative Commons

Siyuan Sun,

Wenqian Yu,

Guangheng Zhang

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Фев. 18, 2025

Gastric cancer (GC) is a prevalent malignant tumor that originates from the epithelial cells of gastric mucosa, predominantly in form adenocarcinoma. Extensive research has confirmed significant role autophagy initiation, progression, and chemoresistance GC. The potential traditional Chinese medicine (TCM) to exert anti-tumor effects by modulating been demonstrated, particularly context GC prevention treatment. Natural products (NPs) have great therapeutic treatment targeting autophagy-related genes signaling pathways intervene biological behaviors such as proliferation, metastasis, invasion death. This article describes molecular mechanisms key markers autophagy, involved GC-associated (PI3K/AKT/mTOR, AMPK, MAPK, p53), summarizes mechanism Helicobacter pylori infection GC, how interacts with apoptotic iron-death processes wide-ranging influences these factors play process. Finally, this paper systematically natural compounds terpenoids, polyphenols, alkaloids, saponins, polysaccharides modulate targets for evaluates toxic NPs, providing more compelling rationale direction therapy.

Язык: Английский

Процитировано

0
Study on the efficacy of IFN-γ- and sPD-1-overexpressing BMSCs in enhancing immune effects for the treatment of lung adenocarcinoma DOI Creative Commons

Yahui Xie,

Zhen Lv,

Y. W. Wang

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Март 13, 2025

Background Soluble programmed cell death receptor-1 (sPD-1) blocks the PD-1/PD-L1 pathway, reverses tumor immune suppression, and inhibits growth. However, clinical applications are limited by its poor tissue distribution rapid dispersion. Bone marrow-derived mesenchymal stem cells (BMSCs) favorable carriers for immunotherapy due to their capacity external gene introduction targeted homing. they may inadvertently promote Interferon-gamma (IFN-γ) BMSC-mediated growth stimulates antigen-presenting activate T lymphocytes. This study utilizes BMSCs transfected with IFN-γ as sPD-1, enabling homing of sPD-1 tissues, thereby enhancing efficacy sustained stability immunotherapy. Methods stable IFN-γ- sPD-1-overexpressing were successfully constructed lentiviral transfection. A non-contact co-culture system was established Lewis A549 lung adenocarcinoma observe changes in cancer after co-culture, using assays including migration invasion experiments, well cellular senescence detection. Additionally, a subcutaneous model C57BL/6J mice intervention studies. Tumor volume, apoptosis (assessed TUNEL assay), peripheral Treg (analyzed flow cytometry), histopathological markers (evaluated HE staining immunohistochemistry) analyzed. The expression levels BAX, BCL-2, AKT, PI3K, PD-L1 assessed quantitative PCR Western Blot. Results exhibited high bioactivity genetic stability, inhibiting proliferation, accelerating senescence, reducing invasion. Furthermore, upregulate Bax expression, downregulate Bcl-2, apoptosis. these alleviate inflammatory damage tumor-bearing mice, lower inhibit evasion, reduce PI3K/AKT PD-L1. Conclusion effectively progression. primary mechanisms include suppression growth, migration, invasion; promotion cells; modulation inhibition signaling pathway pathways.

Язык: Английский

Процитировано

0
Microenvironments‐Targeted Nanomaterials for Atherosclerosis Therapy DOI
Chunli Song, Hao Ling, Guanqing Yang

и другие.

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 26, 2025

Abstract Atherosclerosis significantly contributes to cardiovascular disease. Traditional treatments for atherosclerosis, such as pharmacological interventions and surgical procedures, have demonstrated limited efficacy often yield unsatisfactory results. Consequently, safe effective therapeutic strategies are urgently needed. The atherosclerotic microenvironments, characterized by inflammation driven foam cells, damaged endothelial recruited leukocytes, lipoproteins, inflammatory mediators, play a key role in disease progression. By leveraging the biological components physicochemical properties of these researchers developed microenvironments‐targeted nanomaterials promising approach treat atherosclerosis. These aim address eliminate processes. Their functions include repairing damage, reducing lipoprotein accumulation, inhibiting leukocyte chemotaxis, suppressing cell formation, delaying plaque rupture, preventing thrombosis within plaque. This review highlights mechanisms effects targeting processes microenvironments. Finally, challenges prospects nanomaterial‐based therapies atherosclerosis discussed inspire development that modulate potentially leading clinical applications.

Язык: Английский

Процитировано

0
Inhibition of HOXC11 by artesunate induces ferroptosis and suppresses ovarian cancer progression through transcriptional regulation of the PROM2/PI3K/AKT pathway DOI Creative Commons
Jun Li, Feng Lu,

Yijun Yuan

и другие.

World Journal of Surgical Oncology, Год журнала: 2024, Номер 22(1)

Опубликована: Окт. 8, 2024

Ferroptosis, a non-apoptotic form of regulated cell death, plays critical role in the suppression various tumor types, including ovarian cancer. Artesunate (ART), derivative artemisinin, exhibits extensive antitumor effects and is associated with ferroptosis. This study aimed to investigate mechanisms through which ART induces ferroptosis inhibit

Язык: Английский

Процитировано

2
Resveratrol, Piceatannol, Curcumin, and Quercetin as Therapeutic Targets in Gastric Cancer—Mechanisms and Clinical Implications for Natural Products DOI Creative Commons
Paulina Warias,

Paulina Plewa,

Agata Poniewierska-Baran

и другие.

Molecules, Год журнала: 2024, Номер 30(1), С. 3 - 3

Опубликована: Дек. 24, 2024

Gastric cancer remains a significant global health challenge, driving the need for innovative therapeutic approaches. Natural polyphenolic compounds such as resveratrol, piceatannol, curcumin, and quercetin currently show promising results in prevention treatment of various cancers, due to their diverse biological activities. This review presents effects natural on important processes related cancer, apoptosis, proliferation, migration, invasion, angiogenesis, autophagy. Resveratrol, naturally found red grapes, has been shown induce apoptosis inhibit invasion gastric cells. Piceatannol, metabolite shares similar anticancer properties, particularly modulating Curcumin, derived from turmeric, is known its anti-inflammatory antioxidant ability tumor growth metastasis. Quercetin, flavonoid fruits vegetables, induces cell cycle arrest while enhancing efficacy conventional therapies. Despite potential, challenges low bioavailability limit clinical application, necessitating further research into novel delivery systems. Collectively, these represent avenue improving patient outcomes through multifaceted effects.

Язык: Английский

Процитировано

1