Exploring perceived barriers and attitudes in young adults towards antidepressant pharmacotherapy, including the implementation of pharmacogenetic testing to optimize prescription practices
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 3, 2025
The
field
of
pharmacogenetics
(PGx)
is
experiencing
significant
growth,
with
increasing
evidence
to
support
its
application
in
psychiatric
care,
suggesting
potential
personalize
treatment
plans,
optimize
medication
efficacy,
and
reduce
adverse
drug
reactions.
However,
the
perceived
utility
practicability
PGx
for
youth
remains
underexplored.
This
study
investigated
barriers
attitudes
Australian
young
adults
towards
implementation
testing
guide
antidepressant
primary
care.
Semi-structured
focus
groups
interviews
were
conducted
17
participants
aged
between
18
24
years.
These
sessions
recorded
transcribed
before
thematic
analysis
was
used
identify
collective
themes.
Three
key
themes
identified,
including
prescription
process,
concerns
testing,
clinical
implementation.
Although
positively
by
most
participants,
all
shared
about
testing.
Participants
voiced
financial
impact
delays,
accuracy
guiding
treatment.
Additionally,
noted
that
low
awareness
willingness
general
practitioners
incorporate
into
routine
practice
could
hinder
successful
Prior
practices,
it
essential
acknowledge
patient
perspectives
ensure
practices
remain
patient-focused.
highlights
important
considerations
integrating
pharmacotherapy
emphasizes
need
future
research
address
mitigate
adults.
Язык: Английский
Exploring Youth-Perceived Barriers and Attitudes Towards the Clinical Use of Pharmacogenetic Testing to Optimise Antidepressant Pharmacotherapy
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 26, 2024
Abstract
The
field
of
pharmacogenetics
(PGx)
is
experiencing
significant
growth,
with
increasing
evidence
to
support
its
application
in
psychiatric
care,
suggesting
potential
personalise
treatment
plans,
optimise
medication
efficacy,
and
reduce
adverse
drug
reactions.
However,
the
perceived
utility
practicability
PGx
for
youth
remains
underexplored.
This
study
investigated
youth-perceived
barriers
attitudes
towards
implementation
testing
guide
antidepressant
primary
care.
Semi-structured
focus
groups
interviews
were
conducted
17
participants
aged
between
18
24
years.
These
sessions
recorded
transcribed
before
thematic
analysis
was
used
identify
collective
themes.
Three
key
themes
identified,
including
prescription
process,
concerns
testing,
clinical
implementation.
Although
positively
by
most
participants,
all
shared
about
testing.
Participants
voiced
financial
impact
delays,
accuracy
guiding
treatment.
Additionally,
noted
that
low
awareness
willingness
general
practitioners
incorporate
into
routine
practice
could
hinder
successful
Prior
Australian
practices,
it
essential
acknowledge
patient
perspectives
ensure
practices
remain
patient-focused.
highlights
important
considerations
integrating
pharmacotherapy
emphasizes
need
future
research
address
mitigate
barriers.
Язык: Английский
Analysis of the current situation of pharmacogenomics in terms of educational and healthcare needs in Egypt and Lebanon
Pharmacogenomics,
Год журнала:
2024,
Номер
25(10-11), С. 429 - 440
Опубликована: Июль 23, 2024
Pharmacogenomics
(PGx)
is
a
practice
that
investigates
the
link
between
genetic
differences
and
drug
response
in
patients.
This
can
improve
treatment
effectiveness
reduce
harmful
side
effects.
However,
has
yet
to
be
adequately
realized
developing
nations.
Three
surveys
were
conducted
November
2022
March
2023
Egypt
Lebanon.
The
first
survey
assessed
availability
of
PGx
testing
different
healthcare
facilities;
second
one
knowledge,
interest
attitude
toward
learning
about
among
pharmacists
physicians;
third
providing
education
at
academic
levels.
In
Egypt,
few
surveyed
facilities
are
conducting
some
form
pharmacogenetic
testing.
Lebanon,
very
germline
pharmacogenomic
tests
offered
Greater
Beirut's
leading
hospitals,
no
other
was
recorded.
attracts
considerable
interest,
with
34.3%
interested
48.8%
interested.
Similarly,
24.8%
total
physicians
while
44.8%
Academic
professionals
institutions
both
countries
agreed
on
need
for
educational
programs
78.2%
there
good
opportunities
implementing
These
findings
clearly
indicate
develop
implement
Middle-East.
Язык: Английский
Genetic testing in psychiatry, the perceptions of healthcare workers and patients: a mini review
Frontiers in Public Health,
Год журнала:
2024,
Номер
12
Опубликована: Окт. 10, 2024
Background
Genetic
testing
in
psychiatry
has
gained
attention,
raising
questions
about
its
application
and
impact.
Understanding
stakeholders’
perspectives,
including
healthcare
providers
patients,
is
vital
for
informed
policy
development.
The
aim
of
this
systematic
review
was
to
focus
on
the
perceptions
concerns
patients
workers
regarding
use
genetic
testing.
Methods
We
conducted
a
following
PRISMA
guidelines,
period
1/2/2014,
1/1/2024,
via
PubMed
Embase
databases
identifying
50
articles
total.
After
excluding
duplicates
(
n
=
12),
38
went
through
screening.
careful
full-text
article
assessment
eligibility
applying
inclusion
exclusion
criteria,
only
fifteen
15)
were
included.
Results
Among
15
selected
studies
involving
3,156
participants
(2,347
professionals;
809
patients),
thematic
analysis
identified
four
primary
themes:
Organizational-implementation
concerns,
Ethical
Considerations,
Concerns
changes
clinical
praxis,
Legal
implications.
Despite
these
seven
out
eleven
indicated
that
viewed
positively.
Patients’
perspectives
varied,
with
two
reflecting
positive
attitudes.
No
pervasive
negative
sentiment
observed.
Conclusion
Our
highlights
multidimensional
professionals
surrounding
psychiatry.
These
considerations
need
be
addressed
facilitate
implementation
praxis
Further
research
needed
validation
results
guide
policies
clinicians
integration
into
mental
practice.
Язык: Английский
Pharmacogenomic testing and implications for psychiatric medication prescribing
The Nurse Practitioner,
Год журнала:
2024,
Номер
49(12), С. 24 - 33
Опубликована: Ноя. 21, 2024
ABSTRACT
A
pharmacogenomics-informed
prescribing
strategy
examines
genetic
variations
in
individual
patients
for
more
personalized
selection
and
dosing
of
psychiatric
medications
which
a
clinical
evidence
base
and/or
guidelines
exist.
Clinicians
who
prescribe
should
be
aware
the
pharmacogenomic
existing
relevant
to
medication
selection,
dosing,
interactions
ensure
safe
effective
treatment.
Although
testing
does
not
replace
current
strategies,
when
used
alongside
them,
it
acts
as
valuable
decision
support
tool
that
can
improve
specific
medications.
Язык: Английский
Biomarkers for the prediction and monitoring of the antipsychotic/antidepressant-induced hepatotoxicity: study protocol
Pharmacogenomics,
Год журнала:
2024,
Номер
25(16-18), С. 667 - 678
Опубликована: Дек. 11, 2024
This
study
is
designed
to
address
the
connection
between
antidepressant
and
antipsychotic-induced
hepatotoxicity
with
pharmacogenetic
epigenetic
indicators,
using
a
novel
combined
approach
of
CYP450
polymorphism
determination
early
liver
injury
detection
via
microRNA
testing.
The
multi-centric
retrospective
case-control
in
Slovakia
involves
151
cases
signs
604
controls
without.
Participants
will
be
tested
for
selected
CYP450,
UGT1A1
polymorphisms,
microRNAs.
Anticipated
findings
test
if
patients
specific
polymorphisms
are
at
higher
risk
drug-induced
plasma
microRNAs
hsa-miR-122-5p
hsa-miR-192-5p,
alone
or
combined,
can
differentiate
abnormal
function.
could
contribute
personalized
treatment
by
combining
genetic
biomarkers.
Язык: Английский