Interaction of some chalcone derivatives with calcium channels using a theoretical model DOI
Rosas‐Nexticapa Marcela, Rosas‐Nexticapa Marcela, Magdalena Alvarez-Ramirez

и другие.

Brazilian Journal of Science, Год журнала: 2024, Номер 3(11), С. 1 - 15

Опубликована: Окт. 10, 2024

For several years, different drugs have been used to treat heart failure, such as digoxin, captopril, spironolactone, milrinone, levosimedam, dobutamine, and others. However, some of these can produce secondary effects arrhythmia, cough, hyperkalemia, Analyzing data, this study aimed evaluate the interaction chalcone derivatives (1-17) with calcium channels using theoretical models. It is important mention that 7pjx protein, nifedipine, amlodipine, diltiazem, verapamil were tools in DockingServer program. The results showed differences compared drugs. Other data indicate inhibition constant (Ki) for analog 1 was lower verapamil, diltiazem. Besides, other suggest Ki compound 11 All could act channel inhibitors; phenomenon be translated into changes blood pressure through a decrease intracellular levels. These good therapeutic alternatives failure.

Язык: Английский

Interaction of some chalcone derivatives with calcium channels using a theoretical model DOI
Rosas‐Nexticapa Marcela, Rosas‐Nexticapa Marcela, Magdalena Alvarez-Ramirez

и другие.

Brazilian Journal of Science, Год журнала: 2024, Номер 3(11), С. 1 - 15

Опубликована: Окт. 10, 2024

For several years, different drugs have been used to treat heart failure, such as digoxin, captopril, spironolactone, milrinone, levosimedam, dobutamine, and others. However, some of these can produce secondary effects arrhythmia, cough, hyperkalemia, Analyzing data, this study aimed evaluate the interaction chalcone derivatives (1-17) with calcium channels using theoretical models. It is important mention that 7pjx protein, nifedipine, amlodipine, diltiazem, verapamil were tools in DockingServer program. The results showed differences compared drugs. Other data indicate inhibition constant (Ki) for analog 1 was lower verapamil, diltiazem. Besides, other suggest Ki compound 11 All could act channel inhibitors; phenomenon be translated into changes blood pressure through a decrease intracellular levels. These good therapeutic alternatives failure.

Язык: Английский

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