Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 24, 2024
Background
The
occurrence
of
immune-related
adverse
events
(irAEs)
seemed
to
be
associated
with
better
outcomes
in
advanced
gastric
cancer
(AGC)
patients.
However,
research
focusing
on
the
impact
single-organ
irAE
(uni-irAE)
or
multi-organ
irAEs
(multi-irAEs)
AGC
outcome
is
relatively
limited.
In
this
study,
we
investigated
individually
different
survival
as
well
co-occurrence
patterns
multi-irAEs.
Methods
uni-irAE,
multi-irAEs,
and
non-irAE
were
identified
based
National
Comprehensive
Cancer
Network
(NCCN)
guidelines.
ICI
efficacy
for
disease
control
rate
(DCR)
objective
response
(ORR)
was
assessed
Response
Evaluation
Criteria
Solid
Tumors
(RECIST)
Version
1.1.
association
progression-free
(PFS)
overall
(OS)
analyzed
using
Kaplan–Meier
method
Cox
regression
model.
We
also
performed
pairwise
correlation
analysis
identify
irAEs.
Results
A
total
288
patients
including
175
non-irAE,
73
40
multi-irAE
evaluated
their
outcome.
displayed
higher
DCR
(78.8%
vs.
67.4%,
p
=0.037)
when
compared
those
patients,
both
uni-irAE
(82.2%
=0.019)
(72.5%
=0.534)
showed
than
that
multivariate
analyses
revealed
multi-irAEs
an
independent
risk
factor
PFS
(hazard
ratio
[HR]
0.63,
95%
confidence
interval
[CI]
0.41~0.96,
=0.031)
OS
(HR
0.47,
CI
0.29~0.76,
=0.002),
whereas
not
obtained.
thyroid,
adrenal
gland,
heart,
skin,
lung
exhibited
a
high
organ-specific
experiencing
skin
had
favorable
without
these
Conclusion
Multi-irAEs
some
can
used
predictive
indicators
treatment
are
often
accompanied
by
occurrence.
Drug Development Research,
Год журнала:
2025,
Номер
86(1)
Опубликована: Янв. 20, 2025
ABSTRACT
Chemotherapy
is
an
effective
treatment
for
gastric
cancer.
However,
many
patients
develop
resistance
to
chemotherapeutic
agents
during
clinical
treatment.
LncRNA
CCAT1
has
recently
been
shown
influence
cellular
specific
drugs,
but
its
role
in
cancer
remains
underexplored.
This
study
aims
investigate
the
of
cisplatin
cells
and
potential
underlying
mechanisms.
Gastric
cell
lines
with
acquired
were
established.
The
expression
was
assessed
both
cisplatin‐sensitive
cisplatin‐resistant
AGS
lines.
knocked
down
AGS/DDP
cells,
changes
IC50
values
measured
using
Cell
Counting
Kit‐8
(CCK‐8)
assay.
Apoptosis
evaluated
by
flow
cytometry.
Additionally,
Western
blotting
employed
measure
levels
PI3K/AKT/mTOR
signaling
pathway
proteins
apoptosis‐related
interference
control
groups.
RT‐qPCR
results
indicated
that
significantly
elevated
compared
non‐resistant
cells.
Similarly,
CCK‐8
assay
demonstrated
knocking
resistant
increased
their
sensitivity
Flow
cytometry
blot
further
confirmed
silencing
promoted
apoptosis
these
higher
sensitive
counterparts,
resulted
reduced
proteins.
In
conclusion,
above
studies
induced
Frontiers in Oncology,
Год журнала:
2024,
Номер
14
Опубликована: Фев. 26, 2024
Gastric
cancer
(GC)
remains
one
of
the
most
life-threatening
disease
worldwide
with
poor
prognosis
because
absence
effective
treatment
and
delay
in
diagnosis.
Due
to
diagnosis,
a
large
proportion
GC
patients
are
diagnosed
as
advanced
GC,
extreme
short
lifespan.
In
past
few
years,
some
pivotal
progress
novel
therapies
was
proposed,
conducted
into
clinical
researches
practice.
this
study,
we
summarized
development
several
immunotherapy
or
targeted
modalities
for
including
immune
checkpoint
inhibitors,
anti-angiogenic
therapy
vaccines.
Additionally,
advantage
potential
weakness
each
these
therapeutic
methods
also
listed.
Finally,
discussed
promising
research
direction
treatment,
limitation
basic
combination
therapy.
World Journal of Gastroenterology,
Год журнала:
2024,
Номер
30(8), С. 779 - 793
Опубликована: Фев. 26, 2024
In
this
editorial,
we
comment
on
the
article
entitled
"Advances
and
key
focus
areas
in
gastric
cancer
immunotherapy:
A
comprehensive
scientometric
clinical
trial
review
(1999-2023),"
which
was
published
recent
issue
of
BMJ Open,
Год журнала:
2025,
Номер
15(1), С. e086276 - e086276
Опубликована: Янв. 1, 2025
Introduction
Gastric
cancer
liver
metastases
(GCLM)
is
a
highly
heterogeneous
disease
with
poor
prognosis.
The
multidisciplinary
diagnosis
and
treatment
model
applied
throughout
the
entire
process.
In
addition
to
previous
RECORD
study,
which
was
based
on
C-GCLM
classification
system
developed
by
our
team,
there
lack
of
recent
data
patient
baseline
characteristics,
clinical
efficacy
evaluation.
A
large-scale
prospective
observational
study
necessary
determine
current
situation
GCLM
in
China.
findings
this
may
inform
development
relevant
healthcare
policies,
pathways
guidelines.
Methods
analysis
This
prospective,
non-interventional,
observational,
multicentre,
real-world
designed
monitor
general
condition,
pattern
prognosis
patients
GCLM.
Patients
were
classified
into
three
distinct
categories:
type
I
(resectable
type),
II
(potentially
resectable
type)
III
(unresectable
type).
patients'
information,
medical
history,
imaging
results,
laboratory
tests,
surgical
systemic
therapy
details
will
be
recorded
subjected
analysis.
2-year
overall
survival
(OS)
as
primary
endpoint.
different
therapeutic
modalities
employed
GCLM,
including
surgery,
chemotherapy
immunotherapy,
secondary
endpoints.
Additionally,
effects
these
therapies
prognosis,
OS
I,
III;
R0
resection
disease-free
I;
successful
conversion
rate
event-free
documented.
Ethics
dissemination
involving
human
participants
reviewed
approved
Committee
Chinese
PLA
General
Hospital
(no.
S2023-724-02)
conducted
accordance
guidelines
Declaration
Helsinki.
Study
disseminated
through
international
peer-reviewed
journal
articles
well
public,
academic
presentations
at
national
conferences.
Trial
registration
numbers
NCT06493448
;
ChiCTR2400083955.
Medicine,
Год журнала:
2025,
Номер
104(14), С. e42079 - e42079
Опубликована: Апрель 4, 2025
Antibody-dependent
cellular
phagocytosis
(ADCP)
is
an
immune
biological
process
and
plays
a
role
in
the
clearance
of
tumor
cells
response
to
checkpoint
inhibitors.
However,
effects
ADCP
on
stomach
adenocarcinoma
(STAD)
remain
unclear.
Clinical
genomic
data
were
extracted
from
multiple
datasets.
The
ADCP-related
signature
was
established
using
Cox
least
absolute
shrinkage
selection
operator
regression.
Expression
C5a
receptor
also
known
as
complement
component
5a
1
adjacent-normal
tissues
calculated
immunohistochemistry
staining.
Validation
conducted
training
validation
cohorts
by
regression
log-rank
tests.
Furthermore,
infiltrates,
dysfunction
exclusion
score,
mutation
burden
score
corresponding
algorithms,
Mann–Whitney
U
tests
used
evaluate
differences
between
groups.
Seventy-three
hub
genes
with
predictive
performance
identified
establish
signature.
Accordingly,
27-gene
established,
1,
one
genes,
had
higher
expression
tumors
than
samples,
its
validated
GSE84437
Cancer
Genome
Atlas
cohorts.
We
found
that
excellent
prognostic
predictor
STAD.
Moreover,
molecular
characteristics
some
indices
immunotherapy
differed
high-
low-risk
constructed
associated
prognosis
STAD-based
provide
insights
into
mechanisms
underlying
this
function.
Cancers,
Год журнала:
2024,
Номер
16(12), С. 2251 - 2251
Опубликована: Июнь 18, 2024
Based
on
the
CheckMate
649
trial,
nivolumab
plus
chemotherapy
is
recommended
first-line
treatment
for
HER2-negative
unresectable
advanced
or
metastatic
gastric,
gastroesophageal
junction
(GEJ),
esophageal
adenocarcinoma.
This
nationwide,
multicenter,
retrospective
study
evaluated
real-world
effectiveness
of
this
regimen
in
Turkish
patients
and
identified
subgroups
that
may
experience
superior
outcomes.
Conducted
across
16
oncology
centers
Turkey,
retrospectively
reviewed
clinical
charts
adult
diagnosed
with
GEJ,
adenocarcinoma
from
2016
to
2023.
included
111
(54
women,
57
men)
a
median
age
58
years.
The
progression-free
survival
(PFS)
overall
(OS)
were
11.7
months
18.2
months,
respectively,
whereas
objective
response
rate
(ORR)
was
70.3%.
Multivariable
analyses
revealed
previous
curative
surgery
favorable
independent
prognostic
factor
both
PFS
OS.
Conversely,
an
Eastern
Cooperative
Oncology
Group
performance
status
2
emerged
as
adverse
safety
profile
found
be
manageable.
Our
findings
support
use
Patient
selection
based
characteristics
crucial
optimizing
