Dynamics of thioredoxin 1, thioredoxin reductase 1 and glutathione-S-transferase Pi content in the spleen and liver of rats during the latent period of growth and metastasis of sarcoma C45 DOI Creative Commons
Е. И. Сурикова, E. M. Frantsiyants, И. В. Каплиева

и другие.

Research and Practical Medicine Journal, Год журнала: 2025, Номер 12(1), С. 40 - 51

Опубликована: Март 1, 2025

Purpose of the study . To examine dynamics content thioredoxin 1 (Trx1), reductase (TR1), and glutathione S-transferase Pi (GST Pi) in spleen liver during latent period growth metastasis C45, which occurs approximately one to two weeks after tumor transplantation. Materials methods The experiment was conducted on 28 male rats a white, nonlinear strain. A model hematogenous created by transplanting sarcoma 45 (C45) into spleen, previously dislocated under skin three prior commencement experiment. experimental Groups were as follows: Group ( n = 7) comprised intact rats; 2 skin; 3 week later; 4 later. In each case, had undergone transplantation C45 been skin. concentrations Trx1, TR1, GST quantified homogenates through use enzyme linked immunosorbent assay (ELISA). Results. exhibited significantly elevated p ≤ 0.01) Trx1 TR1 level liver, at 8.3 3.4 times higher, respectively, comparison spleen. Conversely, did not demonstrate notable discrepancy between organs. levels diminished relative 1. 3, increased, while 4, these 1.7 (p 0.05) 5.5 0.001) times, compared Additionally, lower average 2. results demonstrated statistically significant increase with threefold found be 4.6 1.8 remained (2.9 0.01), restored observed 1, along Pi. Conclusion initially greater significance Trx system for homeostasis than that is obvious. During metastasis, antioxidant redox regulating functions activated it inhibited, disrupting organ. activity detoxification glutathionylation processes regulated decreased corresponded reflect possible mechanism an imbalance protective metabolic systems forming basis it.

Язык: Английский

Dynamics of thioredoxin 1, thioredoxin reductase 1 and glutathione-S-transferase Pi content in the spleen and liver of rats during the latent period of growth and metastasis of sarcoma C45 DOI Creative Commons
Е. И. Сурикова, E. M. Frantsiyants, И. В. Каплиева

и другие.

Research and Practical Medicine Journal, Год журнала: 2025, Номер 12(1), С. 40 - 51

Опубликована: Март 1, 2025

Purpose of the study . To examine dynamics content thioredoxin 1 (Trx1), reductase (TR1), and glutathione S-transferase Pi (GST Pi) in spleen liver during latent period growth metastasis C45, which occurs approximately one to two weeks after tumor transplantation. Materials methods The experiment was conducted on 28 male rats a white, nonlinear strain. A model hematogenous created by transplanting sarcoma 45 (C45) into spleen, previously dislocated under skin three prior commencement experiment. experimental Groups were as follows: Group ( n = 7) comprised intact rats; 2 skin; 3 week later; 4 later. In each case, had undergone transplantation C45 been skin. concentrations Trx1, TR1, GST quantified homogenates through use enzyme linked immunosorbent assay (ELISA). Results. exhibited significantly elevated p ≤ 0.01) Trx1 TR1 level liver, at 8.3 3.4 times higher, respectively, comparison spleen. Conversely, did not demonstrate notable discrepancy between organs. levels diminished relative 1. 3, increased, while 4, these 1.7 (p 0.05) 5.5 0.001) times, compared Additionally, lower average 2. results demonstrated statistically significant increase with threefold found be 4.6 1.8 remained (2.9 0.01), restored observed 1, along Pi. Conclusion initially greater significance Trx system for homeostasis than that is obvious. During metastasis, antioxidant redox regulating functions activated it inhibited, disrupting organ. activity detoxification glutathionylation processes regulated decreased corresponded reflect possible mechanism an imbalance protective metabolic systems forming basis it.

Язык: Английский

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