TM9SF1 inhibits Colorectal Cancer Metastasis by Targeting Vimentin for Tollip-Mediated Selective Autophagic Degradation DOI Creative Commons
Zhibo Liu, Huifen Wang, Jia Hu

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 20, 2024

Abstract Selective autophagy is a finely regulated degradation pathway that can either promote or suppress cancer progression depending on its specific target cargoes. In this study, we report transmembrane 9 superfamily member 1 (TM9SF1) suppresses colorectal (CRC) metastasis via selective autophagic of Vimentin. Tm9sf1 knockout significantly increases tumor numbers and size, as well enhances invasion in CRC model. In vitro in vivo phenotypical analyses reveal TM9SF1 functions suppressor CRC. Mechanistically, facilitates the K63-linked ubiquitination Vimentin by E3 ligase tripartite motif containing 21 (TRIM21). The serves recognition signal for mediated cargo receptor toll interacting protein (Tollip). Consequently, downregulation results decreased number F-actin-rich stress fibers filopodium-like protrusions (FLPs), ultimately inhibiting metastasis. Moreover, downregulated patients with advanced stage compared to those early associated favorable prognosis. Overall, our findings identify novel TM9SF1-TRIM21-Tollip-Vimentin involved metastasis, which may provide promising therapeutic targets treatment metastatic

Язык: Английский

TM9SF1 inhibits colorectal cancer metastasis by targeting Vimentin for Tollip-mediated selective autophagic degradation DOI Creative Commons
Huifen Wang, Jia Hu, Di Wang

и другие.

Cell Death and Differentiation, Год журнала: 2025, Номер unknown

Опубликована: Апрель 2, 2025

Язык: Английский

Процитировано

0
TM9SF1 inhibits Colorectal Cancer Metastasis by Targeting Vimentin for Tollip-Mediated Selective Autophagic Degradation DOI Creative Commons
Zhibo Liu, Huifen Wang, Jia Hu

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 20, 2024

Abstract Selective autophagy is a finely regulated degradation pathway that can either promote or suppress cancer progression depending on its specific target cargoes. In this study, we report transmembrane 9 superfamily member 1 (TM9SF1) suppresses colorectal (CRC) metastasis via selective autophagic of Vimentin. Tm9sf1 knockout significantly increases tumor numbers and size, as well enhances invasion in CRC model. In vitro in vivo phenotypical analyses reveal TM9SF1 functions suppressor CRC. Mechanistically, facilitates the K63-linked ubiquitination Vimentin by E3 ligase tripartite motif containing 21 (TRIM21). The serves recognition signal for mediated cargo receptor toll interacting protein (Tollip). Consequently, downregulation results decreased number F-actin-rich stress fibers filopodium-like protrusions (FLPs), ultimately inhibiting metastasis. Moreover, downregulated patients with advanced stage compared to those early associated favorable prognosis. Overall, our findings identify novel TM9SF1-TRIM21-Tollip-Vimentin involved metastasis, which may provide promising therapeutic targets treatment metastatic

Язык: Английский

Процитировано

0