Nanotechnology as a new strategy for the diagnosis and treatment of gliomas
Journal of Cancer,
Год журнала:
2024,
Номер
15(14), С. 4643 - 4655
Опубликована: Янв. 1, 2024
Glioma
is
the
most
common
malignant
tumor
of
central
nervous
system
(CNS),
and
characterized
by
high
aggressiveness
a
recurrence
rate.Currently,
main
treatments
for
gliomas
include
surgical
resection,
temozolomide
chemotherapy
radiotherapy.However,
prognosis
glioma
patients
after
active
standardized
treatment
still
poor,
especially
glioblastoma
(GBM);
median
survival
only
14.6
months,
5-year
rate
4-5%.The
current
challenges
in
difficulty
complete
poor
blood-brain
barrier
(BBB)
drug
permeability,
therapeutic
resistance,
tumor-specific
targeting.In
recent
years,
rapid
development
nanotechnology
has
provided
new
directions
diagnosing
treating
gliomas.Nanoparticles
(NPs)
are
excellent
surface
tunability,
precise
targeting,
biocompatibility,
safety.In
addition,
NPs
can
be
used
gene
therapy,
photodynamic
antiangiogenic
therapy
combined
with
biomaterials
thermotherapy.In
decades,
breakthroughs
have
been
made
various
functional
NPs,
expected
to
become
strategy
diagnosis
treatment.In
this
paper,
we
review
obstacles
discuss
potential
latest
glioma.
Язык: Английский
Deciphering the role of non-coding RNAs SNHG18, HOXA11-AS, MEG3, and MDC1-AS1 in glioma patients: A combined experimental and computational study
Gene Reports,
Год журнала:
2024,
Номер
36, С. 101973 - 101973
Опубликована: Июль 14, 2024
Язык: Английский
Metabolism: an important player in glioma survival and development
Discover Oncology,
Год журнала:
2024,
Номер
15(1)
Опубликована: Окт. 22, 2024
Gliomas
are
malignant
tumors
originating
from
both
neuroglial
cells
and
neural
stem
cells.
The
involvement
of
contributes
to
the
tumor's
heterogeneity,
affecting
its
metabolic
features,
development,
response
therapy.
This
review
provides
a
brief
introduction
importance
metabolism
in
gliomas
before
systematically
categorizing
them
into
specific
groups
based
on
their
histological
molecular
genetic
markers.
Metabolism
plays
critical
role
glioma
biology,
as
tumor
rely
heavily
altered
pathways
support
rapid
growth,
survival,
progression.
Dysregulated
processes,
involving
carbohydrates,
lipids,
amino
acids
not
only
fuel
development
but
also
contribute
therapy
resistance
metastatic
potential.
By
understanding
these
changes,
key
intervention
points,
such
mutations
genes
like
RTK,
EGFR,
RAS,
IDH
can
be
identified,
paving
way
for
novel
therapeutic
strategies.
emphasizes
connection
between
clinical
challenges,
offering
actionable
insights
future
research
gliomas.
Язык: Английский
Current challenges in the treatment of gliomas: The molecular era
World Journal of Clinical Oncology,
Год журнала:
2024,
Номер
15(8), С. 982 - 986
Опубликована: Авг. 16, 2024
Gliomas
originate
from
glial
cells
in
the
central
nervous
system.
Approximately
80%-85%
of
malignant
brain
tumors
adults
are
gliomas.
The
most
common
system
tumor
children
is
low-grade
pediatric
glioma.
Diagnosis
was
determined
by
histological
features
until
2016
when
World
Health
Organization
classification
integrated
molecular
data
with
anatomopathological
information
to
achieve
a
more
integral
diagnosis.
Molecular
characterization
has
led
better
diagnostic
and
prognostic
staging,
which
turn
increased
precision
treatment.
Current
efforts
focused
on
effective
therapies
prolong
survival
improve
quality
life
adult
patients
However,
improvements
have
been
modest.
Currently,
clinical
guidelines,
as
well
article
Mohamed
Язык: Английский