Medicine, Год журнала: 2024, Номер 103(44), С. e40384 - e40384

Опубликована: Ноя. 1, 2024

The intricate interplay between the human immunodeficiency virus (HIV) and immune system has long been a focal point in understanding disease progression. Among myriad of cells, basophils, often overshadowed, have recently emerged as pivotal contributors to complex immunological landscape HIV infection. This paper aims provide succinct overview enigmatic roles basophils pathogenesis, elucidating their multifaceted functions implications. Basophils, conventionally perceived minor players responses, exhibit active participation Their activation triggered by viral antigens, cytokines, complexes orchestrates cascade events, influencing modulation, cytokine release, adaptive cells. Furthermore, function antigen-presenting potentially impacting dissemination dysregulation. Additionally, serve crucial regulators infection through secretion, notably interleukin (IL)-4, IL-13, IL-3, cell differentiation, polarization, antibody production. interactions with various cells intricately shape response against HIV, progression equilibrium. Moreover, harnessing potential vaccine targets or modulators represents compelling avenue for future research. In conclusion, emerging basophils’ involvement challenges prior perceptions underscores significance shaping responses outcomes. abstraction highlights need continued research unlock full paving way novel strategies combatting HIV/AIDS.

Язык: Английский