Allergo Journal International, Год журнала: 2024, Номер unknown
Опубликована: Окт. 2, 2024
Язык: Английский
European Journal of Cancer, Год журнала: 2024, Номер 205, С. 114075 - 114075
Опубликована: Май 4, 2024
Язык: Английский
Процитировано
13
Allergology International, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
The detection of drug-specific activation T cells in the lymphocyte transformation test (LTT) is mainly based on cell proliferation or cytokine secretion. However, LTT presents with a varying sensitivity and specificity. aim our study was to analyse genome wide gene expression PBMC identify drug allergy-specific regulation patterns. Additionally, differences related allergy-inducing type allergy (immediate/delayed) were investigated. Blood samples from 40 patients different drugs non-drug-allergic controls recruited. isolated stimulated culprit ("LTT-platform"). Transcriptome analyses conducted after 3.5 days. concentration IFN-γ IL-5 culture supernatants measured by ELISA 6 transcriptome revealed an patients. Importantly, corresponding control groups these genes barely even opposingly regulated. It also shown that particular cefuroxime exerted strong effect PBMC. Quantitative RT-PCR selected identified CCL17, CISH CD25 specifically upregulated Notably, upregulation did not necessarily correlate outcome controls. Our results could be helpful for identification one panel regulated considering patient specific parameters like drug.
Язык: Английский
Процитировано
1
World Allergy Organization Journal, Год журнала: 2024, Номер 17(9), С. 100946 - 100946
Опубликована: Авг. 20, 2024
Drug provocation tests (DPTs) are also used in some patients with a history of contrast medium (CM)-hypersensitivity reaction. Since the use agents requires special knowledge that is present radiology but not necessarily allergology, this overview should close gaps. The literature, and package inserts industry dealing DPTs hypersensitivity reactions was analyzed results presented. Historical analyses revealed were already done past, called pre-testing. Due to disadvantages, diagnostic tool abandoned. A few years later, DPT introduced as an innovative procedure. has 3 main disadvantages: missing standardization, at risk (such compromised renal function) rarely taken into account, negative does exclude subsequent CM (formerly pre-testing) well-known method for diagnosing CM-related reactions. disadvantages diagnosis outweigh advantages, we propose replacing routine contrast-enhanced imaging examination radiology.
Язык: Английский
Процитировано
5
Fundamental and Clinical Pharmacology, Год журнала: 2024, Номер 38(5), С. 988 - 997
Опубликована: Апрель 8, 2024
Hypersensitivity reactions (HSR) are reported for the macrolides, lincosamides, and streptogramins (MLS) antibiotic family. Data about cross-reactivity among between MLS remain scarce or controversial. The aim of this study was to provide an overview hypersensitivity cross-reactions MLSs based on data extracted from French National Pharmacovigilance Database (FPVD). Cases HSR January 1985 December 2019 were FPVD using standardized MedDRA queries (SMQ). including allergological test involving multiple giving at least one positive result included. Of 8394 cases reviewed, 149 mainly involved pristinamycin (n = 83; 53.2%) spiramycin 31; 19.9%). immediate in 54 delayed 94 cases. Skin tests represented majority performed 728; 84.7%), followed by reintroduction 79; 9.2%). Eighty-six cross-reactivities identified 62 (41.6%). All 25 explorations showed cross-reactivities, but only 30/253 macrolides (11.9%). Cross-reactivities three observed 31/322 (9.6%) explorations. This highlights possibility MLSs. Dermatologists allergologists managing patients with should be aware a risk different classes perform testing before recommending alternative antibiotic, especially severe drug
Язык: Английский
Процитировано
3
HNO, Год журнала: 2024, Номер 72(7), С. 494 - 498
Опубликована: Апрель 10, 2024
Процитировано
3
HNO Nachrichten, Год журнала: 2025, Номер 55(1), С. 38 - 42
Опубликована: Фев. 1, 2025
Процитировано
0
Cureus, Год журнала: 2025, Номер unknown
Опубликована: Фев. 19, 2025
Trimethoprim-sulfamethoxazole (TMP-SMX) is a non-β-lactam antibiotic commonly used in pediatrics to treat infections and as prophylactic medication. Hypersensitivity TMP-SMX generally non-immediate, immediate allergic reactions, including anaphylaxis, are rare. This case report details six-year-old girl who experienced anaphylaxis TMP-SMX. Her skin prick test with was negative, but she developed drug provocation (DPT). An additional basophil activation (BAT) for the combination tablet evaluated confirmed positive. underscores need alternative diagnostic methods like BAT, which pose lower risk than DPT. The findings suggest that BAT could offer safer approach, though more studies required validate its use allergy diagnosis.
Язык: Английский
Процитировано
0
The Journal of Allergy and Clinical Immunology In Practice, Год журнала: 2025, Номер 13(3), С. 718 - 719
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Frontiers in Allergy, Год журнала: 2025, Номер 6
Опубликована: Март 27, 2025
Introduction Cefuroxime allergy may present as a delayed-type reaction or an immunoglobulin (Ig)E-mediated immediate-type anaphylactic reaction. The basophil activation test (BAT) is diagnostic tool for cefuroxime-induced reactions, whereas the lymphocyte transformation (LTT) typically applied in drug allergy. This study aimed to compare results of BAT and LTT 15 patients with reactions considered confirmed. pharmacoepidemiological part analyze spontaneous reports cefuroxime-associated European adverse database (EudraVigilance). Methods In EudraVigilance, 668 Economic Area (EEA) between 2010 2023 were analyzed, 182 (27.2%) these originating from Germany. performed according standard protocols. Except one patient, all prior skin tests, thereafter. Results Almost classified serious (EEA, 99.3%; Germany, 98.9%). 60.8% 66.9% (Germany) respective information, occurred after intravenous administration. was 12 (3/12 positive; sensitivity 25%), while (7/15 46.7%). Conclusions Our analysis highlights importance almost serious. Neither negative nor can rule out sensitization reactions.
Язык: Английский
Процитировано
0
Rheumatology International, Год журнала: 2025, Номер 45(4)
Опубликована: Март 27, 2025
Язык: Английский
Процитировано
0